Volume 2 Issue 1, January 2018

Volume 2 Issue 1

Phytocannabinoids are plant-derived ligands for the cannabinoid receptors. The chemical synthesis of phytocannabinoids and their metabolites will help in the study of scarce or unstable compounds, and potentially provide access to abiological derivatives that may have uses in medicine.

See: Reekie, T. A., Scott, M. P. & Kassiou, M. The evolving science of phytocannabinoids. Nat. Rev. Chem. 2, 0101 (2018). 

Image and design: Rachael Tremlett

Editorial

Research Highlights

Reviews and Perspectives

  • Review Article |

    Some plant-derived ligands for the cannabinoid receptors — phytocannabinoids — are promising pharmaceuticals. This Review covers the chemical synthesis of phytocannabinoids and metabolites to enable the study of compounds otherwise inaccessible on a practical scale. Availability of drug candidates is also hindered by policy issues, which we discuss with regard to possession, use and control.

    • Tristan A. Reekie
    • , Michael P. Scott
    •  & Michael Kassiou
  • Review Article |

    The electrochemical oxidation and reduction of water and carbon dioxide are associated with the release or storage of energy. This Review reports the latest developments in the design and use of low-dimensional materials and their van der Waals heterostructures for electrocatalytic and photocatalytic hydrogen evolution and CO2 conversion.

    • Damien Voiry
    • , Hyeon Suk Shin
    • , Kian Ping Loh
    •  & Manish Chhowalla
  • Perspective |

    Numerous fabrication methods have been developed so far for the production of graphenes and nanographenes. However, how practical is the bulk production of these fascinating materials? This Perspective discusses recent advances in graphene fabrication and possibilities for translation to large-scale production.

    • Xiao-Ye Wang
    • , Akimitsu Narita
    •  & Klaus Müllen
  • Perspective |

    Metal–ligand cooperative catalysis involves both the metal and the ligand moieties present in a complex interacting with substrates. Cooperative catalysis is central to the mechanisms of hydrogenases, lactate racemase and alcohol dehydrogenase. This Perspective describes these enzymes, as well as the small-molecule mimics inspired by these elaborate natural catalysts.

    • Matthew D. Wodrich
    •  & Xile Hu