Volume 1 Issue 8 August 2017

Volume 1 Issue 8

Interlocked molecules — once a synthetic curiosity — have become readily accessible molecules with potential applications in a wide variety of fields, perhaps most famously in the production of molecular machines. The active template method — which uses metal ions to both template assembly and mediate bond formation has enabled the synthesis of ever more complex interlocked structures.

See: Denis, M. & Goldup, S. M. Nat. Rev. Chem. 1, 0061 (2017)

Image and design: Rachael Tremlett

Research Highlights

Reviews and Perspectives

  • Review Article |

    The active template approach to interlocked molecules uses metal ions to both pre-organize reaction components and catalyse the final covalent bond formation that captures the interlocked structure. This Review looks at the history of the method, its application in the synthesis of ever more complex interlocked molecules and future directions.

    • Mathieu Denis
    •  & Stephen M. Goldup


  • Review Article |

    Surface-enhanced Raman scattering (SERS) is a physical phenomenon first discovered in 1974. SERS has since been exploited for bioanalysis because of its high sensitivity and multiplexing capabilities. This Review describes the progress made and problems faced with respect to using in vivo SERS in humans.

    • Stacey Laing
    • , Lauren E. Jamieson
    • , Karen Faulds
    •  & Duncan Graham
  • Review Article |

    Polymeric nanomaterials have a rich history of applications in the selective delivery of small-molecule drugs to their biological targets. This Review discusses the evolution of drug delivery using such polymers and explores how these approaches have evolved in parallel with the ability to prepare ever more architecturally complex macromolecular structures.

    • Ashok Kakkar
    • , Giovanni Traverso
    • , Omid C. Farokhzad
    • , Ralph Weissleder
    •  & Robert Langer
  • Perspective |

    Bis(β-diketiminato)dimagnesium(I) complexes are low-valent reagents that can each deliver two electrons in a selective and stoichiometric manner. Easily handled and dissolved, these species effect reduction of many inorganic and unsaturated organic substrates. This Perspective covers the development of magnesium(I) dimers and the scope of their reactivity.

    • Cameron Jones