Volume 1 Issue 5 May 2017

Volume 1 Issue 5

Quadruplex structures are known to form from guanine rich DNA sequences such as those found in the telomere. Formation of these structures is known to decrease the activity of telomerase, an enzyme whose activity has been implicated in the development of several types of cancer. Small molecules which bind to and stabilize quadruplex DNA are thus being investigated as potential cancer therapeutics.

See  Neidle, S. Nat. Rev. Chem. 1, 0041 (2017).

Image and design: Rachael Tremlett

Research Highlights

Comments and Opinion

  • Comment |

    Although there is a keen awareness of the gender gap in the physical sciences, a healthy female representation has yet to be achieved. This article offers some possible explanations, in addition to strategies to more rapidly achieve gender balance in the physical sciences.

    • Angela K. Wilson

Reviews and Perspectives

  • Perspective |

    Quadruplex DNA structures were first observed more than 50 years ago, but have only relatively recently attracted interest for their role in the development of cancer. This Perspective considers attempts to selectively bind and stabilize these structures using small molecules, with the aim of developing anticancer therapeutics.

    • Stephen Neidle
  • Review Article |

    Homogenous transition metal electrocatalysts are topical owing to their role in processing electrical energy and mediating the synthesis of chemical fuels. Mechanisms can be uncovered using electrochemical techniques and data analyses, along with complementary spectroscopic techniques. This Review presents case studies highlighting the utility of these methods in the context of electrocatalysis for chemical fuel production.

    • Katherine J. Lee
    • , Noémie Elgrishi
    • , Banu Kandemir
    •  & Jillian L. Dempsey
  • Review Article |

    The disconnection of C–H and C–C bonds is an efficient approach to functionalize organic molecules. Particularly useful are transformations in which these two cleavage reactions operate in tandem. This Review describes this tandem strategy and provides examples of its application in synthetic chemistry.

    • Zackaria Nairoukh
    • , Morgan Cormier
    •  & Ilan Marek