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Radiopharmaceuticals are becoming an essential tool in the fight against cancer, and the field has been diversified with the investigation of f-block elements over the past decade. Here we discuss the highlights in 2023 research leading the charge in utilizing f-block elements in innovative ways, changing how we treat these diseases.
Analog-quantum simulations derived from tracking the evolution of trapped-ion systems hold the potential to simulate molecular quantum dynamics that are beyond the reach of classical-digital strategies. This Review explores the prospects for developing this quantum advantage.
Biological assays are essential to pharmaceutical, agrochemical and cosmetics research. However, false readouts pose substantial challenges in screening small molecules. This Review explores the current methods for tackling assay interference, focusing on computational approaches and their integration with experimental methods.
Cutting-edge chemistry is often performed in non-atmospheric conditions. Continued development of the Chemputer platform now enables the utilization of sensitive compounds in automated synthetic protocols.
As researchers explore innovative ways to make nuclear fuels more accident-tolerant, this report investigates the use of manganese ions as dopants for uranium oxide (UO2) fuels.
A highly chemoselective method for the insertion of carbohydrates into existing oligosaccharides has been developed. The reaction sequence involves a selective Lewis-acid catalysed cleavage of one glycosidic bond followed by sequential construction of two new glycosidic bonds.
Peptide stapling is a powerful technique used to lock peptide conformations and modulate peptide functions. This Review highlights the newest development in non-symmetric stapling of native peptides bearing natural amino acids, elucidating current advances, challenges and future opportunities.
Typically thought of as inert and non-participating atoms, noble gasses adsorbed onto freshly cleaved single crystal surfaces enhance their electronic band structures, potentially creating more active heterogeneous catalysts.
The use of water for electrochemical hydrogenation and oxidation of organic species provides a sustainable route for synthesizing chemicals. The electrode types, general electrocatalyst selection principles and interface microenvironment control are elucidated, conducive to designing efficient electrocatalysts and reaction systems.
The Chemical Weapons Convention has a unique Scientific Advisory Board that ensures it keeps pace with science, and its implementing body is prepared for future challenges. It is a model that could be usefully applied to other disarmament treaties.
Organic-based triplet–triplet annihilation upconversion-mediated photochemical reactions utilize low-energy photons to obtain high-energy excited states leading to notable advancements in photoredox catalysis, photoactivation, 3D printing and immunotherapy. Classifications, design principles, challenges and possible solutions are discussed in this Review.
Targeted covalent inhibitors (TCIs) can react irreversibly with lysine in kinases and other proteins. Small molecule TCIs can have both broad or specific lysine targeting whereas peptide- and protein-based TCIs were shown to provide high target specificity for lysines in shallow protein surfaces.
Anion recognition in competitive, aqueous media remains a critical challenge. Bulk and local solvation models for anion recognition events are herein explored, as well as targeted design approaches to retain strong anion binding in highly polar media.
JWST collects vast amounts of information about exoplanets light years away from Earth. Back home, the measured optical constants of laboratory aerosols are critically input parameters in models to interpret the observational results.
Semiconducting polymers require narrow molecular weight distributions for optimal efficiency. Synthesizing such polymers is no easy task, however a combined ultrasonication-assisted Stille polymerization reaction could be the solution to this problem.
Gold catalysts have attracted attention for their ability to activate hydrogen towards the hydrogenation of organic molecules. This Review explores strategies to enhance hydrogen–gold interactions to help design new efficient hydrogenation catalysts.
Electrochemical devices enable clean energy technologies such as hydrogen cells, batteries and solar fuels. Their design is hindered by incomplete information about the electrochemical interface during operation. Complementary optoelectronic probes offer a path to improved mechanistic insights into such interfaces.
The unique properties of selenium have been exploited in protein science. This Review highlights the recent applications of selenium chemistry in protein chemical synthesis, modification, folding, stabilization, the preparation of therapeutic proteins and more.
Chemistry education research is a well-established field that has the potential to inform chemistry teaching at all levels. But to the uninitiated, much of the work can seem descriptive while quantitative studies often suffer from a lack of reproducibility. Here I delve into these characteristics and explain why this should not deter chemistry teachers from engaging.
