Browse Articles

  • Research Highlight |

    Phosphonium adducts of pyridines are labile in basic solution, an undesirable property with regard to organic synthesis. Yet, this very lability proves valuable for the labelling of pyridine and diazines with heavier isotopes of hydrogen.

    • Andrew Bissette
  • Research Highlight |

    Electrocatalytic O2 reduction on metal surfaces is well understood in acidic solution, but the mechanism in basic solution has been a point of contention. On studying the O2 reduction activities of a series of Pt(111)–Cu surface alloys, it becomes clear that the surface-bound oxygenic intermediates are the same regardless of the pH.

    • David Schilter
  • Review Article |

    The metals in polyoxometalates need not be in their highest oxidation states. Indeed, polyoxometalates can exist in reduced forms, and several different metals can be incorporated into various structural archetypes. This Review describes the synthesis and characterization of these complexes, along with their topical catalytic, electronic and biological properties.

    • Nadiia I. Gumerova
    •  & Annette Rompel
  • Review Article |

    Iterative approaches to synthesis have revolutionized the preparation and study of peptides, nucleic acids and sugars. This Review discusses whether and how such iterative syntheses can be applied more broadly towards an ultimate goal of developing a building block approach to the synthesis of most small organic molecules.

    • Jonathan W. Lehmann
    • , Daniel J. Blair
    •  & Martin D. Burke
  • Review Article |

    Building on the theoretical prediction and experimental realization of planar tetracoordinate carbons, there has been great progress in the theoretical prediction of species containing planar pentacoordinate carbon (ppC) centres. From simple clusters such as CAl5+ to complicated ppCs in 2D materials, this Review summarizes the ppC-containing species predicted to date and the design principles behind them.

    • Valentin Vassilev-Galindo
    • , Sudip Pan
    • , Kelling J. Donald
    •  & Gabriel Merino
  • Research Highlight |

    The first detection of rotational features of benzonitrile offers the opportunity to undesrtand the origin of PAHs in space.

    • Gabriella Graziano
  • Research Highlight |

    The practicality of radical polymerizations is limited by their sensitivity to O2. This inhibitor can be enzymatically degraded into H2O2, which is scavenged by pyruvate as part of a new atom transfer radical polymerization (ATRP) methodology.

    • Johannes Kreutzer
  • Review Article |

    The electrochemical oxidation and reduction of water and carbon dioxide are associated with the release or storage of energy. This Review reports the latest developments in the design and use of low-dimensional materials and their van der Waals heterostructures for electrocatalytic and photocatalytic hydrogen evolution and CO2 conversion.

    • Damien Voiry
    • , Hyeon Suk Shin
    • , Kian Ping Loh
    •  & Manish Chhowalla
  • Editorial |

    We give our perspective on one year of publishing Nature Reviews Chemistry.

  • Research Highlight |

    Semiconductor nanocrystals absorb light and are involved in energy transfer to and from surface chromophores. Tuning the nanocrystal- and chromophore-centred exciton energies affords exquisite control over an excited-state equilibrium.

    • David Schilter
  • Review Article |

    Some plant-derived ligands for the cannabinoid receptors — phytocannabinoids — are promising pharmaceuticals. This Review covers the chemical synthesis of phytocannabinoids and metabolites to enable the study of compounds otherwise inaccessible on a practical scale. Availability of drug candidates is also hindered by policy issues, which we discuss with regard to possession, use and control.

    • Tristan A. Reekie
    • , Michael P. Scott
    •  & Michael Kassiou
  • Perspective |

    Numerous fabrication methods have been developed so far for the production of graphenes and nanographenes. However, how practical is the bulk production of these fascinating materials? This Perspective discusses recent advances in graphene fabrication and possibilities for translation to large-scale production.

    • Xiao-Ye Wang
    • , Akimitsu Narita
    •  & Klaus Müllen
  • Perspective |

    Metal–ligand cooperative catalysis involves both the metal and the ligand moieties present in a complex interacting with substrates. Cooperative catalysis is central to the mechanisms of hydrogenases, lactate racemase and alcohol dehydrogenase. This Perspective describes these enzymes, as well as the small-molecule mimics inspired by these elaborate natural catalysts.

    • Matthew D. Wodrich
    •  & Xile Hu
  • Review Article |

    Electrocatalysts for the oxygen reduction reaction are important components of energy technologies such as fuel cells. The study of molecular catalysts affords mechanistic insights that further the development of robust, active and energy-efficient systems. This Review describes state-of-the-art metal complexes that operate either in solution or immobilized on an electrode.

    • Subal Dey
    • , Biswajit Mondal
    • , Sudipta Chatterjee
    • , Atanu Rana
    • , Sk Amanullah
    •  & Abhishek Dey
  • Down to Business |

    Stephen Caddick discusses the role of technology transfer offices and their future in translating research

    • Stephen Caddick
  • Review Article |

    The tunable bandgap of perovskites and their combination in multi-junction solar cells can afford highly efficient photovoltaic technologies. This Review reports the latest developments in tandem multi-junction perovskite solar cells and discusses prospects for this technology to achieve energy conversion efficiencies well beyond those attained by silicon-based cells.

    • Giles E. Eperon
    • , Maximilian T. Hörantner
    •  & Henry J. Snaith
  • Perspective |

    Light-driven artificial molecular switches and motors afford dynamic control of various molecular systems, ranging from catalytic to biological. This Perspective provides insight into the challenges that must be addressed to transition the field from the proof-of-concept stage to realization of its myriad applications.

    • Thomas van Leeuwen
    • , Anouk S. Lubbe
    • , Peter Štacko
    • , Sander J. Wezenberg
    •  & Ben L. Feringa
  • Perspective |

    Reviewing the applications of a solvent would ordinarily be an unusual thing to do, but the unique properties of hexafluoroisopropanol and its applications across a huge swathe of chemistry make that both a viable and interesting undertaking.

    • Ignacio Colomer
    • , Anna E. R. Chamberlain
    • , Maxwell B. Haughey
    •  & Timothy J. Donohoe
  • Perspective |

    Blue energy can be cleanly and renewably harvested from a salinity gradient. The large-scale viability of this non-intermittent source is restricted by certain challenges, including the inefficiency of present harvesting technologies. This Perspective describes how nanofluidics can afford membranes better able to convert chemical potentials to electrical potentials.

    • Alessandro Siria
    • , Marie-Laure Bocquet
    •  & Lydéric Bocquet
  • Editorial |

    Nature Reviews Chemistry welcomes your proposals for review articles. In this editorial, we provide some details on what makes a good proposal.