Concept: Bradley D. Smith / Design: Carl Conway

Non-covalent secret agents

Non-covalent interactions enable chemical agents to spy on cellular targets and report back by fluorescence.

Latest Reviews

  • Review Article |

    Senescence is a state of permanent cell cycle arrest. This Review highlights the chemical characteristics of senescence and how we can use small molecules to target, detect or eliminate senescent cells, as well as to induce or inhibit senescence.

    • Beatriz Lozano-Torres
    • , Alejandra Estepa-Fernández
    • , Miguel Rovira
    • , Mar Orzáez
    • , Manuel Serrano
    • , Ramón Martínez-Máñez
    •  & Félix Sancenón
  • Review Article |

    Natural product biosynthetic pathways are rich in novel enzymology, but identifying the enzymes that perform new transformations remains challenging. This Review describes recently characterized examples of remarkable chemistries catalysed by biosynthetic enzymes and explores the extent of enzymatic novelty that awaits discovery.

    • Thomas A. Scott
    •  & Jörn Piel
  • Review Article |

    FoF1-ATPase is a vital molecular machine in organisms responsible for the catalytic synthesis of the basic energy unit ATP. In this Review, the development of FoF1-ATPase reconstitution into artificial architectures is discussed ultimately leading to the development of stimuli-responsive ATP synthesis.

    • Yi Jia
    •  & Junbai Li
  • Perspective |

    Water oxidation catalysts are key components in water-splitting devices that synthesize fuels by using energy, including that from sunlight. This Perspective presents historical developments in molecular water oxidation catalysis, emphasizing studies of ruthenium complexes that have taught us how to design optimal catalysts.

    • Roc Matheu
    • , Pablo Garrido-Barros
    • , Marcos Gil-Sepulcre
    • , Mehmed Z. Ertem
    • , Xavier Sala
    • , Carolina Gimbert-Suriñach
    •  & Antoni Llobet

News & Comment

  • Research Highlight |

    One can now prepare tertiary amides directly from CO and a tertiary amine by means of an atom-economical Fe-catalyzed reaction.

    • David Schilter
  • Research Highlight |

    The aroma profile of dark chocolate has been elucidated and could be used as a benchmark to study the effect of changes in recipe, processing and storage conditions on its flavour.

    • Eleni Routoula
  • Research Highlight |

    All organisms have developed vital sensory processes that enable prompt reactions in response to external environmental changes. Su and co-workers propose a bioinspired thermoresponsive device made of solid-state nanochannels that induce thermally selective ion transport.

    • Gabriella Graziano
  • Research Highlight |

    A potential new source of hydroxyl radicals – that mediate the reactions of organic aerosols in the atmosphere – has been identified.

    • Claire Ashworth
  • Research Highlight |

    Thermal denaturation of proteins affords species that differ in terms of cofactors and conformations. Ion mobility spectrometry and mass spectrometry can be used to unravel these mixtures and learn the factors stabilizing certain protein forms.

    • David Schilter


Perovskites for Optoelectronics

Perovskite materials have become very promising candidates for a new generation of potentially printable and efficient optoelectronic devices. Photovoltaic devices based on hybrid perovskites now achieve more than 20% photoconversion efficiency, and applications in solid-state lighting, photodetection and lasing are soaring. Their optoelectronic and photophysical properties are under intense scrutiny. This web-collection brings together a selection of multi-disciplinary research and comments published in the Nature journals that explores the basic properties of halide-based perovskite materials and their potential for application in optoelectronics, from solar cells to lasers. It serves to illustrate the road to easily processable and efficient devices by presenting both historical milestones and the crucial landmark studies published in the last 12 months in the Nature journals.