Neutralizing the next threat

The coronavirus pandemic is not yet over. But with one eye on the next threat — be it chemical or biological — how can chemistry keep us, and the key workers we rely on, safe?


  • Two women converse in front of a laptop.

    Nature Reviews Chemistry is committed to facilitating training in peer review and to ensuring that everyone involved in our peer-review process is appropriately recognized. We have therefore joined an initiative to allow and encourage established referees to involve one early-career researcher in our peer-review process


    • Recent findings on the skeletal rearrangement of polycyclic aromatics under oxidative and acidic conditions are envisioned to help development of these Scholl reactions into a more useful and versatile method for synthesizing polycyclic aromatics on the basis of rational design rather than luck.

      • Qian Miao
      News & Views
    • State-of-the-art synthetic methods regularly encounter challenges associated with cost, safety and/or efficiency when proposed for large-scale applications. This Review highlights recent applications of novel reactions/technologies (e.g. photoredox, electrochemistry, C–H activation, reductive coupling and flow chemistry) on the process scale.

      • Kaitlyn Lovato
      • Patrick S. Fier
      • Kevin M. Maloney
      Review Article
    • Radical philicity — the ability of a radical to act as a nucleophile or an electrophile — is an important, yet often poorly understood, concept. In this Review, we present a qualitative method to understand and predict radical philicity by classifying the typical reactivity of more than 30 types of radicals into nucleophilic or electrophilic behaviour.

      • Faeze Parsaee
      • Milinda C. Senarathna
      • Eric R. Welin
      Review Article
    • Radical-pairing interactions were, until recently, considered something of a chemical curiosity. But these weak interactions, on par with hydrogen bonds, are easily switched on and off and, as a result, have become widely exploited in supramolecular chemistry, particularly in the assembly of out-of-equilibrium structures.

      • Kang Cai
      • Long Zhang
      • J. Fraser Stoddart
      Review Article
    • Molecular decoders are single host matrices able to differentiate analytes by their distinct structural accommodations. Ten years ago, Susumu Kitagawa and co-workers described the prototypical molecular decoder and paved the way for molecular sensing. We now revisit this seminal study and discuss some of the advances that have followed.

      • Soumya Mukherjee
      • Sujit K. Ghosh
      News & Views
  • A disilagermirene is a cyclopropene analogue with an unsaturated Si=Ge moiety. Such rings can be generated and stabilized in the presence of Ni, which the Si=Ge group binds through its σ-bond rather than π-bond.

    • David Schilter
    Research Highlight
  • A deep dive into the mechanism of a classic photoredox reaction.

    • Stephen G. Davey
    Research Highlight
  • Laser ablation enables the study of discrete metal difluorides and their reactions with dioxygen and ozone. Metal-fluoride vibrational energies give an indication of the charge on a metal difluoride moiety and help us rationalize the resultant structures.

    • David Schilter
    Research Highlight
  • An experiment that challenged established dogma opened an entirely new avenue for research in the assembly and control of mechanically interlocked compounds.

    • Ali Trabolsi
  • A range of aryl and alkenyl organosodium reagents can be prepared by halogen–sodium exchange reactions with neopentylsodium and may be a useful alternative to widely used organolithium reagents.

    • Stephen G. Davey
    Research Highlight
  • Our review of Nano is the the joint work of Rosalind (9) and Kristy, her Mum.

    • Rosalind N. Turner
    • Kristy L. Turner
    Books & Arts
Celebrating 15 Years of Covalent Organic Frameworks

Celebrating 15 Years of Covalent Organic Frameworks

This collection celebrates 15 years of research on covalent organic frameworks and highlights some of the contributions that were published in journals of the Nature Research portfolio. We hope you enjoy exploring these snippets on the synthesis and structure of COFs, their physical properties, and their application in fields encompassing energy, catalysis, storage and separation.
  • Johannes Kreutzer