A typewriter is generating long strands of DNA

Closing the literacy gap

The efficiency of DNA sequencing is not yet matched by our ability to synthesize it at scale — closing this gap will be essential to meet the needs of the growing number of potential applications.


  • Two women converse in front of a laptop.

    Nature Reviews Chemistry is committed to facilitating training in peer review and to ensuring that everyone involved in our peer-review process is appropriately recognized. We have therefore joined an initiative to allow and encourage established referees to involve one early-career researcher in our peer-review process

  • A Nobel prize medal against a background of chemical glassware

    The 2022 Nobel Prize in Chemistry has been awarded to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless for the development of click chemistry and bioorthogonal chemistry


    • This Review focuses on the fundamental reasons for the increasing role of alkynes in radical cascades and highlights the unique opportunities provided by the inherent structural, energetic and stereoelectronic features of a carbon–carbon triple bond for the controlled design of cascade reactions.

      • Chaowei Hu
      • Justice Mena
      • Igor V. Alabugin
      Review Article
    • Chiral molecules in biosamples are promising biomarkers for disease diagnosis and prognosis. The authors describe techniques for detecting and quantifying small-molecule enantiomers and approaches to improving these techniques.

      • Yaoran Liu
      • Zilong Wu
      • Yuebing Zheng
      Review Article
    • Mycobacterium tuberculosis-mediated metabolism of xenobiotics poses an important research question for antitubercular drug discovery. Identification of the metabolic fate of compounds can inform requisite structure–activity relationship strategies early on in a drug discovery programme towards improving the properties of the compound.

      • Vinayak Singh
      • Godwin Akpeko Dziwornu
      • Kelly Chibale
      Review Article
    • Informatics approaches play an increasingly important role in accelerating the advances of modern materials science. A recent study reports the development of predictive machine learning models to guide the de novo design of through-space charge transfer polymers with full-colour-tunable emission.

      • Xiaolin Liu
      • Chunlei Zhu
      • Ben Zhong Tang
      News & Views
    • Amorphous coordination polymers and metal–organic frameworks can be directly synthesized under mild conditions using a broader range of metals and ligands than their crystalline and crystal-derived counterparts and therefore exhibit different physicochemical properties. This Review discusses the direct synthesis of amorphous coordination polymers, as well as their characterization, properties and applications.

      • Zhixing Lin
      • Joseph J. Richardson
      • Frank Caruso
      Review Article
  • Creating a more inclusive classroom environment starts with educating instructors about the needs of their students. Once those needs are understood, work to address them may not only benefit the small group of students for whom the intervention was intended, but the wider class too.

    • Christina Goudreau Collison
    In the Classroom
  • A thermoelectric material is presented which adopts a tungsten bronze structure with high-entropy properties but without rare-earth metals. Through entropy engineering, the Seebeck coefficient is optimized and the thermal conductivity is minimized, thereby creating the most efficient thermoelectric material of its kind.

    • Alexander Rosu-Finsen
    Research Highlight
  • Abundant metal copper with a catenane ligand system can effectively induce the oxygen reduction reaction, a promising alternative to typical precious-metal electrocatalysts.

    • Stephanie Greed
    Research Highlight
  • A gold nanoparticle colloidal system is used to explore the effect of nanoparticle–substrate interactions on heterogeneous nucleation, providing a simple model for a complex and poorly understood physical process.

    • Hannah Hatcher
    Research Highlight
  • Owing to the diminishing returns of deep learning and the focus on model accuracy, machine learning for chemistry might become an endeavour exclusive to well-funded institutions and industry. Extending the focus to model efficiency and interpretability will make machine learning for chemistry more inclusive and drive methodological progress.

    • Daniel Probst
  • The amount of microplastics released into aquatic environments when synthetic fabrics are laundered can be substantially decreased with a low-friction, liquid-like polymer coating.

    • Stephanie Greed
    Research Highlight
A Nobel Prize medal against a background of chemical glassware

Nobel Prize in Chemistry 2022

The 2022 Nobel Prize in Chemistry has been awarded to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless for the development of click chemistry and bioorthogonal chemistry.