Image: Stephen Davey; Design: Carl Conway

Hidden in plain sight

A rich reservoir of biochemical novelty exists in bacterial natural products that may provide the solution to replacing the therapeutics and agrochemicals that have become ineffective.

Latest Reviews

  • Review Article |

    The application of organocatalysis in biology is still in its infancy. In this Review, we evaluate organocatalytic reactions in terms of their applicability in biological settings, including new technologies in chemical biology and biomedicine.

    • Michelle P. van der Helm
    • , Benjamin Klemm
    •  & Rienk Eelkema
  • Review Article |

    Triboelectric charging is well known to us all and has widespread and important consequences. Nonetheless, its most basic foundations remain poorly understood, and progress is often countered by the emergence of baffling new observations. Recent work shows the difficulty may arise because charging is governed by competing and unstable dynamical processes.

    • Daniel J. Lacks
    •  & Troy Shinbrot
  • Review Article |

    Femtosecond spectroscopy of photosynthetic systems reveals long-lived quantum coherences. This Review focuses on efforts to understand the microscopic origins of these signals and discusses how such coherences may be exploited to probe design principles of photosynthetic light harvesting.

    • Lili Wang
    • , Marco A. Allodi
    •  & Gregory S. Engel
  • Review Article |

    Electrosynthesis is a practical and green route to hydrogen peroxide, and could reduce our dependence on less environmentally friendly oxidants. This Review describes catalyst and reactor designs for highly selective hydrogen peroxide electrosynthesis.

    • Samuel C. Perry
    • , Dhananjai Pangotra
    • , Luciana Vieira
    • , Lénárd-István Csepei
    • , Volker Sieber
    • , Ling Wang
    • , Carlos Ponce de León
    •  & Frank C. Walsh
  • Review Article |

    Senescence is a state of permanent cell cycle arrest. This Review highlights the chemical characteristics of senescence and how we can use small molecules to target, detect or eliminate senescent cells, as well as to induce or inhibit senescence.

    • Beatriz Lozano-Torres
    • , Alejandra Estepa-Fernández
    • , Miguel Rovira
    • , Mar Orzáez
    • , Manuel Serrano
    • , Ramón Martínez-Máñez
    •  & Félix Sancenón
  • Review Article |

    Natural product biosynthetic pathways are rich in novel enzymology, but identifying the enzymes that perform new transformations remains challenging. This Review describes recently characterized examples of remarkable chemistries catalysed by biosynthetic enzymes and explores the extent of enzymatic novelty that awaits discovery.

    • Thomas A. Scott
    •  & Jörn Piel

News & Comment

  • Research Highlight |

    A new route to the aglycone core of the anthracycline idarubicin relies on the global functionalization of tetracene rather than annulation reactions.

    • Stephen G. Davey
  • Comment |

    Three academics who are active on social media explore the motivations for and benefits of engaging with social media, as well as its costs and risks. Overall, they conclude there is a net benefit for themselves, their employers and wider society.

    • Ben Britton
    • , Chris Jackson
    •  & Jessica Wade
  • Research Highlight |

    Metabolic disorders cause anomalous productions of chemicals in our bodies that may lead to serious diseases. Functionalized tattoo inks can be effectively use to constantly detect metabolites.

    • Gabriella Graziano
  • Research Highlight |

    Oleaginous yeasts grown on biomass sustainably produce high yields of triglycerides for use in foods and fuels.

    • David Schilter
  • Research Highlight |

    The presence of water on the moon is now certain, less so its origin. New experimental findings support the idea of water being released from protonated lunar silicates due to heating from micro-meteorite impacts.

    • Tom Henshall
  • Research Highlight |

    One can now prepare tertiary amides directly from CO and a tertiary amine by means of an atom-economical Fe-catalyzed reaction.

    • David Schilter

Collection

Perovskites for Optoelectronics

Perovskite materials have become very promising candidates for a new generation of potentially printable and efficient optoelectronic devices. Photovoltaic devices based on hybrid perovskites now achieve more than 20% photoconversion efficiency, and applications in solid-state lighting, photodetection and lasing are soaring. Their optoelectronic and photophysical properties are under intense scrutiny. This web-collection brings together a selection of multi-disciplinary research and comments published in the Nature journals that explores the basic properties of halide-based perovskite materials and their potential for application in optoelectronics, from solar cells to lasers. It serves to illustrate the road to easily processable and efficient devices by presenting both historical milestones and the crucial landmark studies published in the last 12 months in the Nature journals.