Image: Raphael Rodriguez; Design: Carl Conway

Delivery vehicles

Chemistry is key for improving synthetic materials used in gene delivery vehicles that enable safe, efficient delivery of nucleic acid cargoes to cells and tissues.

Latest Reviews

  • Review Article |

    The modification of DNA at cytosine and thymine, such as methylation, hydroxylation and formylation, might have epigenetic roles. In this Review, the authors discuss established and newer methods for the detection of these modifications in genomic DNA.

    • Mark Berney
    •  & Joanna F. McGouran
  • Review Article |

    Aqueous media containing homogeneously distributed soft dynamic structures can promote a wide range of synthetic and degradative chemical reactions. This promotion is illustrated by selected examples from academia and industry, as well as from the field of prebiotic chemistry.

    • Sandra Serrano-Luginbühl
    • , Kepa Ruiz-Mirazo
    • , Ryszard Ostaszewski
    • , Fabrice Gallou
    •  & Peter Walde
  • Review Article |

    Nitrification and denitrification are responsible for the processing of ammonia fertilizer, ultimately leading to the generation of environmental pollutants that accumulate in waterways and the atmosphere. This Review describes the enzymes involved in these processes, which fascinate with their unusual active sites and the surprising reactions that they catalyse.

    • Nicolai Lehnert
    • , Hai T. Dong
    • , Jill B. Harland
    • , Andrew P. Hunt
    •  & Corey J. White
  • Review Article |

    Non-viral vehicles for the delivery of nucleic acids have potential applications for the treatment of diseases by, for example, restoring, correcting or silencing the expression of genes. In this Review, the authors discuss the latest developments in synthetic materials used for gene delivery and the challenges that must be overcome to transfer these innovations into the clinic.

    • Irene Lostalé-Seijo
    •  & Javier Montenegro
  • Review Article |

    Surface plasmons can redistribute photoenergy over different time, space and energy scales and have been exploited in new spectroscopic techniques. This Review reports on how surface plasmons can also drive chemical reactions by localizing photon, electronic and/or thermal energies.

    • Chao Zhan
    • , Xue-Jiao Chen
    • , Jun Yi
    • , Jian-Feng Li
    • , De-Yin Wu
    •  & Zhong-Qun Tian

News & Comment

  • Research Highlight |

    Certain frustrated Lewis pairs can undergo single electron transfer to give frustrated radical pairs. Such radical pairs have been implicated as important species in the activation of small molecules such as dihydrogen.

    • David Schilter
  • Research Highlight |

    Atomically thin materials that are both electrically conductive and magnetic are highly desirable. Pedersen, Clérac and co-workers report a new layered coordination polymer — CrCl2(pyrazine)2 — that exhibits both conductive and magnetic-type properties.

    • Gabriella Graziano
  • In the Classroom |

    A full grasp of chemistry requires students to be able to connect microscopic reality with symbolic representations. Immersive virtual reality provides a solution for those who need a tangible link between these representations.

    • Simon J. Lancaster
  • Research Highlight |

    Following binding kinetics over time rather than relying on differences in free-energy of binding enables detection of single molecules of mutant DNA with an estimated specificity of 99.99999%.

    • Stephen G. Davey
  • Editorial |

    Enzymes can serve as blueprints for artificial catalysts, the preparation of which may involve anything from biosynthesis of mutants to chemical synthesis of active site mimics.

  • In the Classroom |

    Threshold concepts are the tricky ideas that underpin so much knowledge. In teaching them, it is important to recognize that a correct answer is not necessarily evidence of understanding.

    • Niki Kaiser

Collection

Perovskites for Optoelectronics

Perovskite materials have become very promising candidates for a new generation of potentially printable and efficient optoelectronic devices. Photovoltaic devices based on hybrid perovskites now achieve more than 20% photoconversion efficiency, and applications in solid-state lighting, photodetection and lasing are soaring. Their optoelectronic and photophysical properties are under intense scrutiny. This web-collection brings together a selection of multi-disciplinary research and comments published in the Nature journals that explores the basic properties of halide-based perovskite materials and their potential for application in optoelectronics, from solar cells to lasers. It serves to illustrate the road to easily processable and efficient devices by presenting both historical milestones and the crucial landmark studies published in the last 12 months in the Nature journals.