A non-symmetrically-stapled helical peptide in green is shown bound to  its target in pink.

Constraining conformation

Peptide stapling improves stability and enhances binding. Non-symmetric stapling greatly expands the applicability of the approach, but introduces challenges of chemoselectivity and site-selectivity.


  • Two women converse in front of a laptop.

    Nature Reviews Chemistry is committed to facilitating training in peer review and to ensuring that everyone involved in our peer-review process is appropriately recognized. We have therefore joined an initiative to allow and encourage established referees to involve one early-career researcher in our peer-review process

  • A Nobel prize medal against a background of chemical glassware

    The 2023 Nobel Prize in Chemistry has been awarded to Moungi G. Bawendi, Louis E. Brus and Alexei I. Ekimov for the discovery and synthesis of quantum dots

  • Various common disability icons are shown with a chemistry twist - including a wheelchair user symbol next to a fumehood the hidden disability symbol furnished with a labcoat

    Diversity, equity and inclusion (DEI) initiatives aim to foster a community that better reflects the makeup of society. Following the United Nation's 'International Day of Persons with Disabilities', this living collection highlights an all-too-often overlooked aspect of DEI in chemistry: disability.


    • In 1993, a new route for the synthesis of semiconductor nanocrystals was reported that exploited organometallic chemistry to afford nearly monodisperse particles. 30 years later the award of the 2023 Nobel Prize in Chemistry can be directly traced to this single publication.

      • Mark Green
      News & Views
    • Improving zinc–air batteries is challenging due to kinetics and limited electrochemical reversibility, partly attributed to sluggish four-electron redox chemistry. Now, substantial strides are noted with two-electron redox chemistry and catalysts, resulting in unprecedentedly stable zinc–air batteries with 61% energy efficiencies.

      • Shengmei Chen
      • Chunyi Zhi
      News & Views
    • Intercalation of atoms, ions and molecules is a powerful tool for finely regulating atomically thin, 2D materials. This Review highlights the effects of intercalation in 2D materials and discusses their in situ studies.

      • Ruijie Yang
      • Liang Mei
      • Zhiyuan Zeng
      Review Article
    • Structural and dynamic DNA nanosciences offer unique tools for engineering bottom–up synthetic cells. This Review provides a holistic overview for using DNA as a structural material, for designing functional entities, and for information-processing circuits for adaptive and interactive behaviour.

      • Avik Samanta
      • Lorena Baranda Pellejero
      • Andreas Walther
      Review Article
    • Colloid science has developed through innovative use of silane coupling agents. We highlight the advances in complex colloid synthesis, focussing on 3-trimethoxysilylpropyl methacrylate (TPM) and related compounds. We outline the remarkable properties, unique synthesis strategies and ensuing pioneering applications of TPM colloids.

      • Marlous Kamp
      • Stefano Sacanna
      • Roel P. A. Dullens
      Review Article
  • Catherine Ngila, executive director of the African Foundation for Women and Youth in Education, Science, Technology and Innovation (AFoWYESTI), talks about her experience of academia and her hopes to promote diversity in STEM.

    • J. Catherine Ngila
    • Stephanie Greed
  • Following the success of our current journal club collaborations, we would like to encourage more groups of early-career researchers to get involved.

  • Radiation-induced redox chemistry is an important consideration for practical applications such as production and storage of nuclear fuels. Furthering our fundamental understanding of radioactive elements, here, the decay kinetics of californium in the presence of common anionic compounds is studied.

    • Rachel Meyer
    • Mikaela Pyrch
    • Ambarneil Saha
    Journal Club
  • From high school to distinguished professor of chemistry at Rhodes University, Tebello Nyokong discusses her inspiration and ambitions to promote science in South Africa.

    • Tebello Nyokong
    • Stephanie Greed
  • As researchers explore innovative ways to make nuclear fuels more accident-tolerant, this report investigates the use of manganese ions as dopants for uranium oxide (UO2) fuels.

    • S. Olivia Gunther
    • Bianca Schacherl
    Journal Club
  • Typically thought of as inert and non-participating atoms, noble gasses adsorbed onto freshly cleaved single crystal surfaces enhance their electronic band structures, potentially creating more active heterogeneous catalysts.

    • Alexander Rosu-Finsen
    Research Highlight
Various common disability icons are shown with a chemistry twist - including a wheelchair user symbol next to a fumehood the hidden disability symbol furnished with a labcoat

Disability inclusion in chemistry

A collection to highlight an all-too-often overlooked aspect of DEI in chemistry: disability.
  • Stephanie Greed