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  • A long-standing nanoparticle delivery paradigm in cancer, that is, the enhanced permeability and retention effect, has been challenged, shifting the focus to active delivery mechanisms, which may provide a new mechanistic foundation for nanoparticle design.

    Editorial
  • The cryopreservation of biological samples is hindered by ice formation and the need to maintain samples under cryogenic conditions during storage and transportation. Silicification offers a simple method for preserving life within refractory, amorphous silicon dioxide, which is analogous to vitreous ice but does not melt and thereby avoids cold-chain issues.

    • Sishi Guo
    • C. Jeffrey Brinker
    • Wei Zhu
    Comment
  • The Navion, a clinical-scale electromagnetic navigation system, is the result of over 20 years of development. Its motivation began in 2003 with the goal of controlling the motion of magnetic microrobots; however, its first clinical use is proving to be for guiding magnetic catheters, guidewires and endoscopes.

    • Bradley J. Nelson
    Down to Business
  • An article in Nature reports a leadless photoelectrochemical device that exploits a new type of diode junction to regulate heartbeats by light.

    • Christine-Maria Horejs
    Research Highlight
  • An article in Nature Communications reports the development of cultured meat with organoleptic properties by regulating the differentiation of stem cells to produce muscle and fat blocks.

    • Nesma El-Sayed Ibrahim
    Research Highlight
  • Harnessing the potential of microbiota analysis creates new opportunities in diagnosing diseases, improving treatment efficacy, reducing treatment complications and preventing disease recurrence. However, microbiota analysis has not yet been integrated into clinical management workflows. Here, we discuss crucial characteristics of microbiota analysis systems for clinical translation.

    • Jyong-Huei Lee
    • Siew Mei Chin
    • Pak Kin Wong
    Comment
  • An article in Nature Communications reports a battery-free, self-powered pacemaker for long-time treatment of arrhythmia.

    • Sadra Bakhshandeh
    Research Highlight
  • The struggle of establishing a successful academic career while starting a family drives many researchers, in particular, women, out of academia. Pausing the academic clock and individualizing performance assessment may thus help reduce gender inequalities in academia.

    Editorial
  • Open-source design of medical devices, following the concept of frugal engineering, provides unrestricted descriptions of technical details, allowing the low-cost and local fabrication of devices to reduce global inequities in healthcare.

    • Jorge Otero
    • Joshua M. Pearce
    • Ramon Farré
    Comment
  • Combining the precision of CRISPR’s DNA searching ability with the speed and scalability of electronics, we have developed an ‘electronic DNA search engine’, called a CRISPR–Chip, which not only enables DNA detection without amplification, but also showcases the untapped potential of merging molecular biology with nanomaterial electronics. Here, we discuss highlights and challenges on the journey from the initial idea to the commercialization of the CRISPR–Chip.

    • Kiana Aran
    • Brett R. Goldsmith
    Down to Business
  • The current drug development pipeline is time-consuming, costly and inefficient. To better model interactions between pharmaceuticals and human physiology and, thus, increase the likelihood of drug success in clinical trials, the effect of pharmacokinetic drug profiles on cellular behaviour should be tested early in drug development.

    • Catherine S. Leasure
    • Gregor Neuert
    Comment
  • An article in Nature Communications reports an injectable hydrogel electrode to stimulate and restore the native pacing of the heart.

    • Sadra Bakhshandeh
    Research Highlight
  • One year in, we take stock of the areas we published, our outreach efforts and our authorship, looking ahead at what comes next in Nature Reviews Bioengineering.

    Editorial
  • Antimicrobial peptides have the potential to combat the growing threat of antimicrobial resistance; however, their clinical translation remains challenging. Here, we discuss molecular farming as a sustainable approach to antimicrobial peptide production, outlining different platforms to produce antimicrobial peptides using plants and viral vectors.

    • Shahid Chaudhary
    • Magdy M. Mahfouz
    Comment
  • Academic research plays a central role in the translational ecosystem, sitting on one end of the valley of death, that is, the gap between preclinical research and real-world clinical applications. Considering clinical need and applicability early in research and development, and knowing about regulatory and commercialization processes, may help academics push innovations across the valley.

    Editorial
  • An article in Communications Engineering reports the development of menstrual pads made of a plant-based high-quality absorption material.

    • Nesma El-Sayed Ibrahim
    Research Highlight
  • In addition to systemic inequity, the lack of adequate parental leave conditions at many US institutions can negatively affect career trajectories for women in STEM. Support structures are needed at the institutional, departmental and funding agency level to promote the success of pregnant women and parents with childcare responsibilities in academia.

    • Natalie Boehnke
    • Liangliang Hao
    Comment
  • Social connections are an important means for people to cope with adversity and illness. Thus, technologies, such as social network analysis, that can leverage close, face-to-face social networks could help optimize healthcare interventions and reduce healthcare-related costs, particularly in low-resource settings.

    • Shivkumar Vishnempet Shridhar
    • Nicholas A. Christakis
    Comment