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  • Access to prosthetic and orthotic devices remains limited in low- and middle-income countries (LMICs) due to the lack of manufacturing and specialized healthcare facilities, and the limited access to skilled, certified medical personnel. Rise Bionics makes devices with digital fabrication and access-conscious engineering to increase accessibility and affordability.

    • Arun Cherian
    • Shriya Srinivasan
    Down to Business
  • Silk protein can be applied as an edible food coating to extend the shelf life of food products by slowing dehydration and reducing oxidative stresses. Here, we highlight the commercialization of Mori Silk, from lab discovery and first proof of concept to manufacturing, scale-up, field validation, regulatory approval and forward-looking challenges.

    • Benedetto Marelli
    • Adam Behrens
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  • At Pulmobiotics, we engineer bacteria for the treatment of respiratory diseases. Here, we outline how we designed MycoChassis — an attenuated bacterium strain obtained by genome engineering of Mycoplasma pneumoniae (a human lung pathogen) — and discuss the challenges on the road to its clinical translation.

    • Maria Lluch-Senar
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  • Animal cells can be cultured in vitro to fabricate meat-like, edible products with the aim to provide a sustainable source of animal protein while improving animal welfare and reducing the environmental impact of meat production. CellX is a China-based startup company that aims to commercialize cultured meat in China.

    • Ning Xiang
    • Ximing Zhang
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  • The Spark M-20 is a nanotechnology-based, handheld device that detects toxic methanol in beverages and sanitizers, which may soon also be applied for intoxication screening in human breath. Here, we share our pathway and experiences during the translation of this university-originated innovation into a commercial product that today is serving customers in 23 countries on 6 continents.

    • Andreas T. Güntner
    • Matteo D’Andria
    • Jan van den Broek
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  • The Gx Sweat Patch is a wearable microfluidic sweat sensor that can be worn by athletes to monitor their sweating rate and sweat chloride concentration. Here, we highlight the commercialization of the Gx Sweat Patch, from developing and optimizing prototypes of a wearable sweat-sensing platform, to validation in competitive individual and team-sport athletes, and the challenges of commercial launch.

    • Roozbeh Ghaffari
    • Alexander J. Aranyosi
    • Lindsay B. Baker
    Down to Business