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  • Microfluidic 3D cell culture platforms may serve as tools for the modelling of human tissues. This Review discusses the design, standardization and automation of such systems for non-clinical drug evaluation and investigation of disease.

    • Jihoon Ko
    • Dohyun Park
    • Noo Li Jeon
    Review Article
  • What does global health equity mean? In bioengineering, ‘equity’ is often interpreted as global ‘access’ to technologies, thereby neglecting wider structural inequalities. Here we suggest that concepts of equity need to be expanded to incorporate principles of equitable representation and recognition within the innovation ecosystem.

    • Alice Street
    • Maïwenn Kersaudy Kerhoas
    • Zibusiso Ndlovu
  • Ultrasound is an emerging tool for tissue engineering with the distinct advantages of cytocompatibility and deep tissue penetration. This Review discusses the integration of ultrasound for cellular assembly and tissue maturation with tissue-engineering techniques to advance regenerative medicine.

    • Kai Melde
    • Athanasios G. Athanassiadis
    • Peer Fischer
    Review Article
  • Hydrogels are being explored and clinically applied for a variety of biomedical and clinical applications. This Review outlines a model-based modular hydrogel design framework that is application-driven and considers clinical translation early in the design process, emphasizing the importance of fundamental modelling and standardized design.

    • Nathan Richbourg
    • Marissa E. Wechsler
    • Nicholas A. Peppas
    Review Article
  • The application of nanoscale drug delivery systems by subcutaneous (SC) administration may circumvent disadvantages of other injections routes, such as intramuscular and intravenous administration. This Review discusses the design and clinical translation of nanoscale drug delivery systems for SC administration for the treatment of various conditions.

    • Lorenzo Tomasini
    • Marianne Ferrere
    • Julien Nicolas
    Review Article
  • Micro- and nanorobots present a promising approach for navigating within the body and eliminating biofilm infections. Their motion can be remotely controlled by external fields and tracked by clinical imaging. They can mechanically disrupt the biofilm matrix and kill the dormant bacterial cells synergistically, thereby improving the effectiveness of biofilm eradication.

    • Bonan Sun
    • Staffan Kjelleberg
    • Li Zhang
  • A long-standing nanoparticle delivery paradigm in cancer, that is, the enhanced permeability and retention effect, has been challenged, shifting the focus to active delivery mechanisms, which may provide a new mechanistic foundation for nanoparticle design.

  • The cryopreservation of biological samples is hindered by ice formation and the need to maintain samples under cryogenic conditions during storage and transportation. Silicification offers a simple method for preserving life within refractory, amorphous silicon dioxide, which is analogous to vitreous ice but does not melt and thereby avoids cold-chain issues.

    • Sishi Guo
    • C. Jeffrey Brinker
    • Wei Zhu
  • Small-scale wireless soft robotic devices are promising tools for various medical applications. This Review outlines safety, navigation and functionality challenges, as well as the ethical and regulatory considerations that remain to be addressed for their clinical translation.

    • Tianlu Wang
    • Yingdan Wu
    • Metin Sitti
    Review Article
  • The Navion, a clinical-scale electromagnetic navigation system, is the result of over 20 years of development. Its motivation began in 2003 with the goal of controlling the motion of magnetic microrobots; however, its first clinical use is proving to be for guiding magnetic catheters, guidewires and endoscopes.

    • Bradley J. Nelson
    Down to Business
  • An article in Nature reports a leadless photoelectrochemical device that exploits a new type of diode junction to regulate heartbeats by light.

    • Christine-Maria Horejs
    Research Highlight
  • An article in Nature Communications reports the development of cultured meat with organoleptic properties by regulating the differentiation of stem cells to produce muscle and fat blocks.

    • Nesma El-Sayed Ibrahim
    Research Highlight
  • Harnessing the potential of microbiota analysis creates new opportunities in diagnosing diseases, improving treatment efficacy, reducing treatment complications and preventing disease recurrence. However, microbiota analysis has not yet been integrated into clinical management workflows. Here, we discuss crucial characteristics of microbiota analysis systems for clinical translation.

    • Jyong-Huei Lee
    • Siew Mei Chin
    • Pak Kin Wong
  • Traditional urinalysis relies on endogenous biomarkers, which have limited diagnostic sensitivity and specificity. This Review discusses molecular optical probes that interact with disease biomarkers in vivo and produce artificial urinary biomarkers, which are excreted into urine for remote urinalysis.

    • Cheng Xu
    • Kanyi Pu
    Review Article
  • An article in Nature Communications reports a battery-free, self-powered pacemaker for long-time treatment of arrhythmia.

    • Sadra Bakhshandeh
    Research Highlight
  • Artificial intelligence (AI) and machine learning (ML) are reshaping antibiotic discovery. In this Review, ML approaches that have been and can be used to address issues hindering antimicrobial peptide identification and development are surveyed.

    • Fangping Wan
    • Felix Wong
    • Cesar de la Fuente-Nunez
    Review Article
  • Mechanoneural interfaces combine surgically modified soft tissues and artificial components to enhance peripheral neural signalling for the reconstruction of bionic limbs. This Review discusses different mechanoneural interface architectures and presents preclinical and clinical evidence of their afferent and efferent properties.

    • Tony Shu
    • Guillermo Herrera-Arcos
    • Hugh M. Herr
    Review Article
  • The struggle of establishing a successful academic career while starting a family drives many researchers, in particular, women, out of academia. Pausing the academic clock and individualizing performance assessment may thus help reduce gender inequalities in academia.