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Our July issue

Striking the simplicity-complexity balance, soft bioelectronics, hydrogel design, bioelectronic interfaces, organoids integrated with organs-on-chips, nanoscale anisotropy and more

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    Interested in meeting our editors in a virtual lab or site visit? Click the link above to find out more.

  • A plate with 3D-printed meat, tomatoes, rice, a glas of milk handed by a robot

    This collection brings together articles discussing the science and societal implications of engineered food, from genome-edited crops and computer-aided food engineering to cellular agriculture, nanotechnology-enabled plant agriculture and agricultural robotics.

  • Engineering visual

    Nature Reviews Bioengineering is launching a competition asking students and Postdocs around the globe to theoretically tackle some of the most pressing bioengineering challenges. Three challenges are awaiting innovative and creative solutions – from the idea to the sketch of a prototype – take part now!

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  • Drug delivery systems can be integrated with cell therapies to improve the efficacy and safety of therapeutic cells. This Review discusses the design of nanoscale, microscale and macroscale drug delivery systems for precise cell modulation, targeted cell and cargo delivery and cell protection.

    • Lily Li-Wen Wang
    • Yongsheng Gao
    • Samir Mitragotri
    Review Article
  • Bioengineering breakthroughs often arise from deceptively simple solutions, leveraging scalability, modularity and ease-of-use. However, certain biomedical applications require the integration of custom-engineered, patient-specific complexity. Striking this simplicity–complexity balance will drive affordable, globalized health innovations.

    Editorial
  • At the Gates Foundation, the newly established Women’s Health Innovations team supports the research, development and increased access to innovative products, devices and platforms aimed at improving women’s health. Importantly, women should have a central role in the women’s health innovation ecosystem, leading research, shaping strategies and making funding decisions.

    • Ru-fong Joanne Cheng
    • Mark A. Barone
    Comment
  • Human brain organoids can partly mimic features of the human brain. This Perspective discusses key ethical considerations in human brain organoid research and introduces an ethical framework of mindful innovation to conceptualize and guide ethical considerations of human brain organoid research.

    • Nathan A. Shlobin
    • Julian Savulescu
    • Matthew L. Baum
    Perspective
  • Insect-derived proteins and fats present viable food constituents. They can be bioengineered and fermented to improve their nutritional value and functionality to promote food security and the development of new superfoods. Nonetheless, scale-up production and translation of insect-derived proteins and fats remain difficult.

    • Seyed Mohammad Taghi Gharibzahedi
    • Zeynep Altintas
    Comment
  • Nanoparticles, such as gold nanoparticles and magnetic ferrite nanoparticles, can be applied in biosensors for disease detection. This Review discusses the design of nanoparticles for clinical diagnostics, focusing on their optimization and device construction for the detection of nucleic acids, proteins and small molecules.

    • Jiyong Cheong
    • Ala Jo
    • Jinwoo Cheon
    Review Article
  • Cell engineering by synthetic biology typically relies on synthetic gene constructs that compete with the host cell for intracellular resources. This Review discusses how such resource competition can impact mammalian cell engineering and outlines strategies for how to mitigate cellular burden using circuit-centric and host-centric approaches.

    • Roberto Di Blasi
    • Jacopo Gabrielli
    • Francesca Ceroni
    Review Article
  • Microbial nanowires are attractive materials for the fabrication of electronic devices because they are sustainably produced and can be genetically reengineered for a broad range of functionalities. Guberman-Pfeffer and colleagues describe novel devices and mass production strategies that have been demonstrated and outline the optimization strategies required for their commercialization.

    • Matthew J. Guberman-Pfeffer
    • Noémie-Manuelle Dorval Courchesne
    • Derek R. Lovley
    Review Article
  • Organoids and organs-on-chips aim to improve drug testing and disease modelling, but each has limitations. This Review discusses the integration of these systems to improve cellular hierarchy, structural fidelity, reproducibility, throughput, scale-up and efficiency to improve translational outcomes.

    • Yimu Zhao
    • Shira Landau
    • Milica Radisic
    Review Article