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Volume 5 Issue 11, November 2023

MOF mediates mitochondrial acetylation

The lysine acetyltransferase MOF promotes acetylation of nuclear and non-nuclear proteins, such as COX17, which facilitates assembly of cytochrome c oxidase in mitochondria. The image depicts mouse embryonic fibroblasts, with the mitochondrial network (TOM20) in green, its overlap with COX17 in yellow and the nucleus stained in blue.

See Guhathakurta et al.

Image: Sukanya Guhathakurta, Max Planck Institute for Immunobiology and Epigenetics. Cover Design: Thomas Phillips.


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Comment & Opinion

  • In 1923, Otto Warburg published his landmark study, in which he described his seminal observations related to metabolic shifts in cancer, often referred to as the Warburg effect. His work laid the foundation for an understanding of how metabolic reconfiguration contributes to cancer onset and progression. Several researchers in the field share their thoughts on what this discovery means to them and how it has inspired their scientific journey.

    • Craig B. Thompson
    • Karen H. Vousden
    • Caroline R. Bartman
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News & Views

  • By analysing the effect of disrupting microbiota during in vivo reprogramming, Kovatcheva et al. demonstrated that vitamin B12-dependent metabolism is a limiting factor for cellular reprogramming and plasticity, and propose its therapeutic supplementation for the improvement of tissue repair.

    • Alba Vílchez-Acosta
    • Gabriela Desdín-Micó
    • Alejandro Ocampo
    News & Views
  • Mitochondrial proteins are frequently acetylated, but most of these modifications are thought to occur non-enzymatically, rather than requiring an acetyltransferase. A new study by Akhtar and colleagues challenges this view by demonstrating that MOF, a well-characterized histone acetyltransferase, bolsters mitochondrial metabolism by acetylating the complex IV assembly factor COX17.

    • Natalie Niemi
    News & Views
  • Group 3 innate lymphoid cells (ILC3s) maintain intestinal barrier integrity and nutrient absorption via IL-22; however, little is known about how these immune cells fuel effector function. Wu et al. now report that uptake of dietary proline acts as a critical metabolic modulator of the ILC3 transcriptome and cytokine production to maintain gut health.

    • Matthew R. Hepworth
    News & Views
  • Glucose transporter-mediated uptake of glucose is a key metabolic checkpoint in T cells. Fu et al. have identified GLUT2 as a critical regulator of CD8+ T cell metabolism and function in response to glucose and oxygen availability.

    • Xuemei Tong
    News & Views
  • Neuronal energization and memory formation in the fruit fly are found to be conditioned by the shuttling of alanine between glial cells and neurons. This observation highlights the emerging role of energy metabolism as a driver of tissue function.

    • L. Felipe Barros
    News & Views
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Research Briefings

  • Analysis of cells shed from the mouse gut, using bulk and single-cell transcriptomics, as well as single-molecule FISH and intravital imaging, revealed that shed cells are diverse, remain viable for a few hours and upregulate anti-microbial gene expression programs.

    Research Briefing
  • The molecular underpinnings of the extensive cellular, morphological and functional plasticity of skeletal muscle in exercise training are poorly understood. We have now begun to unravel the complex epigenetic, transcriptional and proteomic networks that determine the muscle response to exercise in a manner depending on the training state.

    Research Briefing
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