Volume 4

  • No. 9 September 2022

    Spatial metabolomics meets isotopic metabolic tracing

    These images show the distribution of lipid species in control mouse kidneys (the top three lines) and mouse kidneys with ischaemia–reperfusion injury (the bottom two lines) as recorded by high-spatial-resolution MALDI-MSI. These images indicate the species and heterogeneity of lipids in different types of renal cell, which are disturbed after injury; therefore, they can be used to identify injured renal cells in situ.

    See Wang et al.

  • No. 8 August 2022

    Protective progenitors

    Zhang et al. identify functionally distinct adipose progenitor subpopulations in mouse perigonadal adipose tissue, and go on to show that altering the adipogenic capacity of such progenitors has beneficial effects on metabolic health in adulthood. The cover image depicts a haematoxylin and eosin stain of a transverse section of the mouse gonadal region three days after birth.

    See Zhang et al.

  • No. 7 July 2022

    Focus: Neural control of energy homeostasis

    Different brain regions coordinate metabolic processes that range from dictating feeding behavior to shaping energy storage and expenditure. At the cellular level, metabolic networks influence neural function and survival. A better understanding of these processes has advanced our knowledge in how the brain regulates whole-body energy homeostasis.

    See Cheng et al., Alcántara, Miranda-Tapia et al., Nampoothiri et al., Busquets-García et al. and Pekkurnaz and Wang

  • No. 6 June 2022

    Vascular nutrient acquisition signals

    Ong et al. demonstrate how YAP/TAZ and mTORC1 signalling intersect in endothelial cells to regulate nutrient acquisition and vascular growth. The cover depicts a mouse retina, labelled for PECAM (cyan), VE-cadherin (grey) and phosphorylated ribosomal protein S6 (red), indicating high mTORC1 signalling in angiogenic endothelial cells of the growing vascular network.

    See Ong et al.

  • No. 5 May 2022

    Ammonia couples glutaminolysis with lipogenesis

    Cheng et al. report that ammonia released from glutaminolysis binds to SCAP to trigger its dissociation from Insig, thus activating SREBP-1 and promoting lipogenesis to support tumour growth. Depicted is a human lung tumor section with adjacent normal tissue stained for SREBP-1.

    See Cheng et al.

  • No. 4 April 2022

    Methionine-regulated resolution

    Apoptotic cell-derived methionine is shown to be taken up by macrophages through efferocytosis and is used for epigenetic regulation of genes involved in mediating resolution of inflammation.

    See Ampomah et al.

  • No. 3 March 2022

    Angiocrine polyamines regulate adiposity

    Polyamines produced by endothelial cells in white adipose tissue support adipocyte lipolysis and have a role in maintaining healthy adipose tissue homeostasis. The cover image represents an artistic illustration of this concept, depicting the endothelium (magenta), polyamines (ultramarine), adipose tissue (yellow) and free fatty acids (yellow droplets), which are released as a result of lipolysis.

    See Monelli et al.

  • No. 2 February 2022

    Ketones support memory formation in the starving fly

    Silva et al. show that, during starvation, neurons use glial-derived ketone bodies to sustain memory formation in flies. The expression of a neuronal ketone body transporter is shown here in a posterior view of the Drosophila brain.

    See Silva et al.

  • No. 1 January 2022

    Mechanisms of MODY8

    CEL protein is produced in pancreatic acinar cells and is mutated in MODY8. Mutant CEL protein from acinar cells is shown to transfer to and aggregate in beta-cells during MODY8, contributing to beta-cell dysfunction. Depicted is a healthy human pancreas section stained for CEL (red), insulin (green) and nuclei (blue).

    See Kahraman et al.