Volume 3

  • No. 11 November 2021

    SARS-CoV-2 replication relies on lipids

    Cellular fatty acid synthesis is shown to be required for SARS-CoV-2 replication, and treatment with inhibitors of fatty acid synthase inhibits SARS-CoV-2 replication and prolongs survival in vitro and in vivo.

    See Chu, Xing, and Du et al.

  • No. 10 October 2021

    Embryonic metabolism

    The metabolic landscape of early murine embryo development is reconstructed, which provides insight into the metabolic processes associated with the transition of cells from totipotency to pluripotency.

    See Zhao, Yao, Yu, Zhang, Xu et al.

  • No. 9 September 2021

    Intestinal maladaptation in obesity

    At a single-cell level, the molecular mechanisms underlying changes to intestinal stem cells during an obesogenic diet are described, casting light on intestinal maladaptation during obesity.

    See Aliluev and Tritschler et al.

  • No. 8 August 2021

    Leptin enters the brain through a tanycyte shuttle

    Duquenne et al. find that leptin’s entry into the brain is mediated by a tanycyte LepR–EGFR shuttle, which is required for leptin’s peripheral actions.

    SeeDuquenne et al.

  • No. 7 July 2021

    Malaria metabolomics

    The malaria parasite, Plasmodium falciparum, is commonly transmitted by mosquitoes. Abdrabou et al. map longitudinal changes in the serum metabolome and transcriptional changes in immune cells in children from two different ethnic groups in West Africa, before and after exposure to seasonal malaria, thereby identifying an immunosuppressive role of endogenous steroids induced by P. falciparum infection.

    See Abdrabou et al.

  • No. 6 June 2021

    Painful PUFAs

    A diet rich in ω-6 polyunsaturated fatty acidsis shown to lead to the development of peripheral nerve damage in mice, thus revealing a mechanism through which dietary habitscan act as a risk factor for chronic pain.

    See Boyd et al.

  • No. 5 May 2021

    The metabolic roots of breast cancer subtypes in mammary epithelial cells

    Mahendralingam et al. find that the lineage-rooted metabolic identities of normal mammary cells reflect the metabolism of breast cancer subtypes.

    See Mahendralingam et al.

  • No. 4 April 2021

    Thermogenic adipocyte progenitors in perivascular adipose tissue

    Angueira et al. and Shamsi et al. identify populations of vascular smooth muscle cells that give rise to thermogenic adipocyte progenitors in brown and perivascular adipose tissues.

    See Angueira et al. and Shamsi et al.

  • No. 3 March 2021

    Metabolizing alcohol via ALDH2 in cerebellar astrocytes

    Jin et al. find that acetate produced by ALDH2 in cerebellar astrocytes contributes to the behavioural effects of alcohol.

    See Jin et al.

  • No. 2 February 2021

    Untangling the central and peripheral GLP-1 signalling circuitry

    Brierley et al. find that central and peripheral GLP-1 systems suppress eating via independent gut–brain circuits.

    See Brierley et al.

  • No. 1 January 2021

    Organelle-associated long non-coding RNAs

    Sang et al. identify subcellularly localized long non-coding RNAs that respond to nutrient stress, characterizing the mitochondrial lncRNA GAS5 in tuning tricarboxylic acid flux.

    See Sang et al.