Reviews & Analysis

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  • Adipose tissue plays a critical role in systemic metabolism. This work describes how perturbations in the adipocyte progenitor cell repertoire during the perinatal period exert long-lasting metabolic effects in adulthood.

    • Silvia Corvera
    News & Views
  • Measurements of oxygen consumption rates have been central to the resurgent interest in studying cellular metabolism. To enhance the overall reproducibility and reliability of these measurements, Divakaruni and Jastroch provide a guide advising on the selection of experimental models and instrumentation as well as the analysis and interpretation of data.

    • Ajit S. Divakaruni
    • Martin Jastroch
    Review Article
  • The authors of this Perspective summarize the state of human islet research and compare available islet procurement methods, proposing strategies to increase collaboration and standardization to accelerate discoveries on diabetes.

    • Anna L. Gloyn
    • Mark Ibberson
    • Michele Solimena
  • Evanna Mills and Edward Chouchani share the experience of their successful mentor–mentee relationship and talk about the challenges of starting a new lab — both from a recent perspective and five years on.

    • Evanna L. Mills
    • Edward T. Chouchani
  • New research reports that targeting the asialoglycoprotein receptor (ASGR1) in mice promotes cholesterol excretion through a mechanism involving stabilization of LXR without lipogenesis activation, strengthening the idea of therapeutically targeting ASGR1 to lower blood cholesterol and risk of atherosclerotic cardiovascular disease.

    • Daniel J. Rader
    News & Views
  • Longer duration of breastfeeding is shown to have long-lasting effects in rodents, which lead to an adult phenotype that is resistant to diet-induced obesity and has increased brown adipose tissue activity through a process dependent on hypothalamic FGF21 signalling.

    • Elisa Félix-Soriano
    • Kristin I. Stanford
    News & Views
  • The hindbrain is mostly known to participate in eating behaviour by controlling short-term meal parameters and aversive responses to gut malaise. Cheng et al. review current evidence revealing non-aversive neuronal circuits in the hindbrain that are relevant for initiation and termination of homeostatic feeding, as well as for the long-term control of body weight.

    • Wenwen Cheng
    • Desiree Gordian
    • Martin G. Myers Jr.
    Review Article
  • Methanol is a promising feedstock owing to its low price, abundance, energy richness and renewability. However, the toxicity of methanol limits methanol-based biomanufacturing. Rescuing methylotrophic yeast from cell death by restoring phospholipid metabolism enables high-level production of free fatty acids from methanol.

    • Eun Yeol Lee
    • Arslan Sarwar
    News & Views
  • Ultraviolet radiation exerts differential effects in men and women. Parikh et al. reveal that solar exposure on the skin triggers food-seeking behaviour in males, but not females, through a mechanism dependent on ghrelin secretion from skin adipocytes.

    • Carlos Dieguez
    • Ruben Nogueiras
    News & Views
  • In this Perspective, Pekkurnaz and Wang offer an integrative overview on how mitochondrial homeostasis and diversity in morphology, distribution, composition and function contribute to meeting specific cellular demands, with a special focus on neurons

    • Gulcin Pekkurnaz
    • Xinnan Wang
  • Busquets-García et al. provide a historical perspective of the discovery of endocannabinoid signalling and summarize the most recent findings on the role of endocannabinoids in the regulation of intracellular metabolism and its implications for whole-body homeostasis.

    • Arnau Busquets-García
    • Juan P. Bolaños
    • Giovanni Marsicano
    Metabolic Messengers
  • Anti-PD-1 immunotherapy has emerged as a revolutionary therapeutic strategy against cancer. However, it often leads to undesired side effects. In this issue, a new study reports how PD-1 signalling drives metabolic dysregulation in colonic lymphoid tissue inducer cells, thus contributing to the development of intestinal inflammation.

    • Laura Surace
    • Christoph Wilhelm
    News & Views
  • Hepatic inflammation is a major co-morbidity in obesity. New work shows that activated brown adipose tissue releases maresin-2, a lipid molecule derived from docosahexaenoic acid, which targets the liver and actively protects against obesity-induced hepatic inflammation.

    • Francesc Villarroya
    • Aleix Gavaldà-Navarro
    News & Views
  • Reactive oxygen species (ROS) have important roles in health and disease, but are chemically complex and difficult to measure accurately. This consensus statement proposes guidelines and best practices on the nomenclature and assessment of ROS, oxidative reactions and oxidative damage in cells, tissues and in vivo.

    • Michael P. Murphy
    • Hülya Bayir
    • Barry Halliwell
    Consensus Statement
  • NAD+ is a key electron acceptor in proliferating cells, needed to increase biomass. Computational and experimental approaches demonstrate that NAD+ regeneration is critical for de novo lipid synthesis when exogenous sources are limited, underlying cancer cell dependence on lipids when mitochondrial respiration is reduced.

    • Xu Han
    • M. Celeste Simon
    News & Views
  • Ong et al. uncover a role for the YAP/TAZ–TEAD transcriptional pathways in retinal angiogenesis via the regulation of amino acid transporters and assessed mTORC activation. These findings establish the mechanism through which endothelial cells regulate nutrient acquisition and consumption.

    • Roxana E. Oberkersch
    • Massimo M. Santoro
    News & Views
  • Gasser et al. provide a concise overview of the known metabolic functions of endogenous FGF1 and discuss its therapeutic potential after peripheral or central administration.

    • Emanuel Gasser
    • Gencer Sancar
    • Ronald M. Evans
    Metabolic Messengers
  • Itaconate is an immunomodulatory Krebs cycle-derived metabolite. Description of two isomers of itaconate, mesaconate and citraconate, which have overlapping and distinct properties when compared with itaconate in macrophages, expands the knowledge of this intriguing family of immunomodulatory metabolites.

    • Anne F. McGettrick
    • Luke A. J. O’Neill
    News & Views