Latest Research

  • Review Article |

    Franco et al, review how metabolic insufficiency and prolonged stress responses impact signaling cascades and epigenetic reprogramming to lock T cells into an exhausted state.

    • Fabien Franco
    • , Alison Jaccard
    • , Pedro Romero
    • , Yi-Ru Yu
    •  & Ping-Chih Ho
  • Article |

    Linke et al. use unbiased and quantitative techniques to directly link both known and unknown liver and plasma lipid moieties to specific genomic loci, as compiled in a public web resource, LipidGenie. LipidGenie aided in the identification of a new group of sex-specific phosphatidylcholines.

    • Vanessa Linke
    • , Katherine A. Overmyer
    • , Ian J. Miller
    • , Dain R. Brademan
    • , Paul D. Hutchins
    • , Edna A. Trujillo
    • , Thiru R. Reddy
    • , Jason D. Russell
    • , Emily M. Cushing
    • , Kathryn L. Schueler
    • , Donald S. Stapleton
    • , Mary E. Rabaglia
    • , Mark P. Keller
    • , Daniel M. Gatti
    • , Gregory R. Keele
    • , Duy Pham
    • , Karl W. Broman
    • , Gary A. Churchill
    • , Alan D. Attie
    •  & Joshua J. Coon
  • Article |

    After activation, conventional T cells undergo metabolic reprogramming. de Kivit et al. show that in human thymic regulatory T cells, TNFR2 stimulation promotes a glycolytic switch with a preferential glucose-derived carbon flux into the TCA cycle to support suppressive functions.

    • Sander de Kivit
    • , Mark Mensink
    • , Anna T. Hoekstra
    • , Ilana Berlin
    • , Rico J. E. Derks
    • , Demi Both
    • , Muhammad A. Aslam
    • , Derk Amsen
    • , Celia R. Berkers
    •  & Jannie Borst
  • Article |

    Electron transport chain (ETC) regulation can have important consequences for cellular bioenergetics. Here, Acín-Pérez et al. show that macrophage ETC regulation by the Fgr kinase can also affect systemic metabolism in the setting of diet-induced obesity.

    • Rebeca Acín-Pérez
    • , Salvador Iborra
    • , Yolanda Martí-Mateos
    • , Emma C. L. Cook
    • , Ruth Conde-Garrosa
    • , Anton Petcherski
    • , Mª del Mar Muñoz
    • , Raquel Martínez de Mena
    • , Karthickeyan Chella Krishnan
    • , Concepción Jiménez
    • , Juan Pedro Bolaños
    • , Markku Laakso
    • , Aldon J. Lusis
    • , Orian S. Shirihai
    • , David Sancho
    •  & José Antonio Enríquez
  • Review Article |

    Exercise is a powerful modifier of organismal, tissue and cellular metabolism. In their Review, Koelwyn et al. highlight how exercise-induced alterations in the tumour microenvironment can affect immunometabolic mechanisms and how these changes may contribute to the benefits of exercise on cancer initiation and progression.

    • Graeme J. Koelwyn
    • , Xueqian Zhuang
    • , Tuomas Tammela
    • , Andrea Schietinger
    •  & Lee W. Jones
  • Review Article |

    Kusuyama et al. review the effects of maternal and paternal exercise on offspring metabolic health in adulthood, the time of life when metabolic diseases typically surface.

    • Joji Kusuyama
    • , Ana Barbara Alves-Wagner
    • , Nathan S. Makarewicz
    •  & Laurie J. Goodyear
  • Article |

    Pharmacological targeting of de novo lipogenesis is an attractive clinical target for a wide range of diseases. Kelly et al. report that de novo lipogenesis is essential for platelet production in primates, but not in dogs and rats.

    • Kenneth L. Kelly
    • , William J. Reagan
    • , Gabriele E. Sonnenberg
    • , Michelle Clasquin
    • , Katherine Hales
    • , Shoh Asano
    • , Paul A. Amor
    • , Santos Carvajal-Gonzalez
    • , Norimitsu Shirai
    • , Marcy D. Matthews
    • , Kelvin W. Li
    • , Marc K. Hellerstein
    • , Nicholas B. Vera
    • , Trenton T. Ross
    • , Gregg Cappon
    • , Arthur Bergman
    • , Clare Buckeridge
    • , Zhongyuan Sun
    • , Enida Ziso Qejvanaj
    • , Theodore Schmahai
    • , David Beebe
    • , Jeffrey A. Pfefferkorn
    •  & William P. Esler
  • Article |

    Xia et al. provide a method for deep learning of 3D facial images to predict biological age with an accuracy of ±2.8 yr from chronological age and its correlation with lifestyle indicators and blood transcriptomic age.

    • Xian Xia
    • , Xingwei Chen
    • , Gang Wu
    • , Fang Li
    • , Yiyang Wang
    • , Yang Chen
    • , Mingxu Chen
    • , Xinyu Wang
    • , Weiyang Chen
    • , Bo Xian
    • , Weizhong Chen
    • , Yaqiang Cao
    • , Chi Xu
    • , Wenxuan Gong
    • , Guoyu Chen
    • , Donghong Cai
    • , Wenxin Wei
    • , Yizhen Yan
    • , Kangping Liu
    • , Nan Qiao
    • , Xiaohui Zhao
    • , Jin Jia
    • , Wei Wang
    • , Brian K. Kennedy
    • , Kang Zhang
    • , Carlo V. Cannistraci
    • , Yong Zhou
    •  & Jing-Dong J. Han
  • Letter |

    A single intracerebroventricular injection of FGF1 leads to a remarkable remission of diabetes in various rodent models. Here, Alonge et al. show that FGF1-induced diabetes remission in rats requires remodelling of perineuronal nets that enmesh glucoregulatory neurons in the arcuate nucleus.

    • Kimberly M. Alonge
    • , Zaman Mirzadeh
    • , Jarrad M. Scarlett
    • , Aric F. Logsdon
    • , Jenny M. Brown
    • , Elaine Cabrales
    • , Christina K. Chan
    • , Karl J. Kaiyala
    • , Marie A. Bentsen
    • , William A. Banks
    • , Miklos Guttman
    • , Thomas N. Wight
    • , Gregory J. Morton
    •  & Michael W. Schwartz
  • Letter |

    Yu et al. report a preparation that enables transplantation of pancreatic islets underneath the skin and achieves long-term euglycaemia in several preclinical models of type 1 diabetes, thus providing a simple method that might enable a more widespread adoption of islet transplantation in the clinic.

    • Ming Yu
    • , Divyansh Agarwal
    • , Laxminarayana Korutla
    • , Catherine L. May
    • , Wei Wang
    • , Negin Noorchashm Griffith
    • , Bernhard J. Hering
    • , Klaus H. Kaestner
    • , Omaida C. Velazquez
    • , James F. Markmann
    • , Prashanth Vallabhajosyula
    • , Chengyang Liu
    •  & Ali Naji
  • Letter |

    The authors report the case of a young patient who displayed insulin-dependent diabetes after SARS-CoV-2 infection in the absence of autoantibodies indicative of autoimmune type 1 diabetes.

    • Tim Hollstein
    • , Dominik M. Schulte
    • , Juliane Schulz
    • , Andreas Glück
    • , Anette G. Ziegler
    • , Ezio Bonifacio
    • , Mareike Wendorff
    • , Andre Franke
    • , Stefan Schreiber
    • , Stefan R. Bornstein
    •  & Matthias Laudes
  • Article |

    Carbohydrate metabolism in germ cells is shown to promote sugar appetite in female flies, thus demonstrating how metabolism in a subset of cells alters whole-animal behaviour.

    • Zita Carvalho-Santos
    • , Rita Cardoso-Figueiredo
    • , Ana Paula Elias
    • , Ibrahim Tastekin
    • , Célia Baltazar
    •  & Carlos Ribeiro
  • Letter |

    The reprogramming factor Glis1 is shown to drive cellular metabolic changes that in turn promote epigenetic alterations that facilitate induction of pluripotency.

    • Linpeng Li
    • , Keshi Chen
    • , Tianyu Wang
    • , Yi Wu
    • , Guangsuo Xing
    • , Mengqi Chen
    • , Zhihong Hao
    • , Cheng Zhang
    • , Jinye Zhang
    • , Bochao Ma
    • , Zihuang Liu
    • , Hao Yuan
    • , Zijian Liu
    • , Qi Long
    • , Yanshuang Zhou
    • , Juntao Qi
    • , Danyun Zhao
    • , Mi Gao
    • , Duanqing Pei
    • , Jinfu Nie
    • , Dan Ye
    • , Guangjin Pan
    •  & Xingguo Liu
  • Article |

    Fructose consumption has greatly increased in recent years and has been linked to the development of hepatic steatosis. Here, the authors show that fructose promotes gut-barrier deterioration and subsequent endotoxaemia that in turn induces hepatic lipogenesis by activation TLR signalling in liver macrophages.

    • Jelena Todoric
    • , Giuseppe Di Caro
    • , Saskia Reibe
    • , Darren C. Henstridge
    • , Courtney R. Green
    • , Alison Vrbanac
    • , Fatih Ceteci
    • , Claire Conche
    • , Reginald McNulty
    • , Shabnam Shalapour
    • , Koji Taniguchi
    • , Peter J. Meikle
    • , Jeramie D. Watrous
    • , Rafael Moranchel
    • , Mahan Najhawan
    • , Mohit Jain
    • , Xiao Liu
    • , Tatiana Kisseleva
    • , Maria T. Diaz-Meco
    • , Jorge Moscat
    • , Rob Knight
    • , Florian R. Greten
    • , Lester F. Lau
    • , Christian M. Metallo
    • , Mark A. Febbraio
    •  & Michael Karin
  • Article |

    Whereas peripheral axons regenerate well after injury, axons located in the central nervous system, such as in the spinal cord, do not. Kong et al. identify AMPK as a regulator of neuronal regeneration and show that deletion of AMPKα1 promotes regeneration of injured spinal cord axons in mice.

    • Guiping Kong
    • , Luming Zhou
    • , Elisabeth Serger
    • , Ilaria Palmisano
    • , Francesco De Virgiliis
    • , Thomas H. Hutson
    • , Eilidh Mclachlan
    • , Anja Freiwald
    • , Paolo La Montanara
    • , Kirill Shkura
    • , Radhika Puttagunta
    •  & Simone Di Giovanni
  • Viewpoint |

    In this instalment of Career pathways, we hear from Anja Zeigerer and Myriam Aouadi about how the support of institutions, labs and families can galvanize scientists’ passion and productivity.

    • Myriam Aouadi
    •  & Anja Zeigerer
  • Review Article |

    Cellular metabolic demand skyrockets during intense exercise, thus rendering the communication of metabolic state essential for organismal homeostasis. Murphy, Watt and Febbraio discuss the physiological processes governing intertissue communication during exercise and the molecules mediating such cross-talk.

    • Robyn M. Murphy
    • , Matthew J. Watt
    •  & Mark A. Febbraio
  • Review Article |

    Hargreaves and Spriet review regulatory mechanisms of ATP resynthesis during exercise and summarize nutritional interventions that target muscle metabolism to enhance athletic performance.

    • Mark Hargreaves
    •  & Lawrence L. Spriet
  • Article |

    Cancer cells have heightened demands for non-essential amino acids to support proliferation and redox homeostasis. Here, Zhang et al. propose the intersection of cysteine metabolism and polyamine synthesis as an unexplored metabolic vulnerability of cancer cells.

    • Tong Zhang
    • , Christin Bauer
    • , Alice C. Newman
    • , Alejandro Huerta Uribe
    • , Dimitris Athineos
    • , Karen Blyth
    •  & Oliver D. K. Maddocks
  • Article |

    Transient glucose restriction after the activation of CD8+ TE cells ex vivo induces metabolic remodelling that enhances effector functions and tumour clearance in mice.

    • Ramon I. Klein Geltink
    • , Joy Edwards-Hicks
    • , Petya Apostolova
    • , David O’Sullivan
    • , David E. Sanin
    • , Annette E. Patterson
    • , Daniel J. Puleston
    • , Nina A. M. Ligthart
    • , Joerg M. Buescher
    • , Katarzyna M. Grzes
    • , Agnieszka M. Kabat
    • , Michal Stanczak
    • , Jonathan D. Curtis
    • , Fabian Hässler
    • , Franziska M. Uhl
    • , Mario Fabri
    • , Robert Zeiser
    • , Edward J. Pearce
    •  & Erika L. Pearce
  • Perspective |

    Zhang et al. discuss insights into the genetics of extreme human longevity and how genetics knowledge can be harnessed to guide the development of new therapies to extend human healthspan.

    • Zhengdong D. Zhang
    • , Sofiya Milman
    • , Jhih-Rong Lin
    • , Shayne Wierbowski
    • , Haiyuan Yu
    • , Nir Barzilai
    • , Vera Gorbunova
    • , Warren C. Ladiges
    • , Laura J. Niedernhofer
    • , Yousin Suh
    • , Paul D. Robbins
    •  & Jan Vijg
  • Article |

    Levels of the glycolytic intermediate metabolite dihydroxyacetone phosphate are shown to signal cellular glucose availability to the mTORC1 complex through an AMPK-independent route.

    • Jose M. Orozco
    • , Patrycja A. Krawczyk
    • , Sonia M. Scaria
    • , Andrew L. Cangelosi
    • , Sze Ham Chan
    • , Tenzin Kunchok
    • , Caroline A. Lewis
    •  & David M. Sabatini
  • Article |

    Pluripotent stem cell–derived beta cells to treat type 1 diabetes are vulnerable to autoimmune destruction following transplantation. Using an in vivo CRISPR screen, Cai et al. identify RNLS as a modifier of beta cell vulnerability to autoimmune destruction.

    • Erica P. Cai
    • , Yuki Ishikawa
    • , Wei Zhang
    • , Nayara C. Leite
    • , Jian Li
    • , Shurong Hou
    • , Badr Kiaf
    • , Jennifer Hollister-Lock
    • , Nese Kurt Yilmaz
    • , Celia A. Schiffer
    • , Douglas A. Melton
    • , Stephan Kissler
    •  & Peng Yi
  • Letter |

    Steinberg and colleagues show that long-chain fatty acyl-CoA esters are endogenous ligands for the drug-binding domain of AMPK β1–containing isoforms, and that such binding is critical for enhancement of fatty acid oxidation. These data may help explain how AMPK integrates responses to ketogenic diets, fasting or endurance exercise across distinct tissues in the absence of changes in adenine nucleotides.

    • Stephen L. Pinkosky
    • , John W. Scott
    • , Eric M. Desjardins
    • , Brennan K. Smith
    • , Emily A. Day
    • , Rebecca J. Ford
    • , Christopher G. Langendorf
    • , Naomi X. Y. Ling
    • , Tracy L. Nero
    • , Kim Loh
    • , Sandra Galic
    • , Ashfaqul Hoque
    • , William J. Smiles
    • , Kevin R. W. Ngoei
    • , Michael W. Parker
    • , Yan Yan
    • , Karsten Melcher
    • , Bruce E. Kemp
    • , Jonathan S. Oakhill
    •  & Gregory R. Steinberg
  • Article |

    Zhu and colleagues show that chronic activation of arcuate nucleus GABA+ neurons, agouti-related protein (AgRP) neurons alone or non-AgRP GABA+ neurons promotes severe obesity, but only inhibition of all GABA+ neurons can reverse the obese phenotype of hyperphagic mice, thus suggesting a redundant role for arcuate GABA+ neurons in obesity.

    • Canjun Zhu
    • , Zhiying Jiang
    • , Yuanzhong Xu
    • , Zhao-Lin Cai
    • , Qingyan Jiang
    • , Yong Xu
    • , Mingshan Xue
    • , Benjamin R. Arenkiel
    • , Qi Wu
    • , Gang Shu
    •  & Qingchun Tong
  • Perspective |

    Enerbäck and Rabinowitz summarize emerging evidence that lactate serves as a universal circulating fuel for mammalian cells.

    • Joshua D. Rabinowitz
    •  & Sven Enerbäck
  • Article |

    Chen et al. show that a prior history of hyperglycaemia can induce persistent DNA methylation changes at key CpGs to facilitate metabolic memory (the effect of early metabolic control on risk of developing diabetic complications later in life) and trigger diabetic complications, through modifying enhancer activity at myeloid and other cells.

    • Zhuo Chen
    • , Feng Miao
    • , Barbara H. Braffett
    • , John M. Lachin
    • , Lingxiao Zhang
    • , Xiwei Wu
    • , Delnaz Roshandel
    • , Melanie Carless
    • , Xuejun Arthur Li
    • , Joshua D. Tompkins
    • , John S. Kaddis
    • , Arthur D. Riggs
    • , Andrew D. Paterson
    • , Barbara H. Braffet
    • , John M. Lachin
    • , Zhuo Chen
    • , Feng Miao
    • , Lingxiao Zhang
    • , Rama Natarajan
    • , Andrew D. Paterson
    •  & Rama Natarajan
  • Article |

    Legouis et al. demonstrate that glucose synthesis from lactate in the renal proximal tubule is impaired during acute kidney injury (AKI), leading to metabolic abnormalities, which then contribute to increased morbidity and mortality of patients with AKI.

    • David Legouis
    • , Sven-Erick Ricksten
    • , Anna Faivre
    • , Thomas Verissimo
    • , Karim Gariani
    • , Charles Verney
    • , Pierre Galichon
    • , Lena Berchtold
    • , Eric Feraille
    • , Marylise Fernandez
    • , Sandrine Placier
    • , Kari Koppitch
    • , Alexandre Hertig
    • , Pierre-Yves Martin
    • , Maarten Naesens
    • , Jérôme Pugin
    • , Andrew P. McMahon
    • , Pietro E. Cippà
    •  & Sophie de Seigneux
  • Article |

    The muscular and organismal response to exercise training is reduced in animal models associated with chronic hyperglycaemia, thus suggesting that chronic hyperglycaemia inhibits aerobic adaptation to exercise.

    • Tara L. MacDonald
    • , Pattarawan Pattamaprapanont
    • , Prerana Pathak
    • , Natalie Fernandez
    • , Ellen C. Freitas
    • , Samar Hafida
    • , Joanna Mitri
    • , Steven L. Britton
    • , Lauren G. Koch
    •  & Sarah J. Lessard
  • Article |

    Brigger et al. show that adipose tissue eosinophil dysfunction with age underpins physiological features of ageing, including global inflammation, loss of physical fitness and myeloid skewing. Eosinophils transferred from young to aged mice reversed these features and improved immunological fitness in old age, in part via IL-4.

    • Daniel Brigger
    • , Carsten Riether
    • , Robin van Brummelen
    • , Kira I. Mosher
    • , Alicia Shiu
    • , Zhaoqing Ding
    • , Noemi Zbären
    • , Pascal Gasser
    • , Pascal Guntern
    • , Hanadie Yousef
    • , Joseph M. Castellano
    • , Federico Storni
    • , Neill Graff-Radford
    • , Markus Britschgi
    • , Denis Grandgirard
    • , Magdalena Hinterbrandner
    • , Mark Siegrist
    • , Norman Moullan
    • , Willy Hofstetter
    • , Stephen L. Leib
    • , Peter M. Villiger
    • , Johan Auwerx
    • , Saul A. Villeda
    • , Tony Wyss-Coray
    • , Mario Noti
    •  & Alexander Eggel
  • Article |

    Zhu et al. show how cancer-associated fibroblasts (CAFs) regulate metabolism of branched-chain amino acids in pancreatic ductal adenocarcinomas. CAFs secrete and deliver branched-chain ketoacids to cancer cells by degrading proteins in the extracellular matrix that are internalized from the tumour microenvironment.

    • Ziwen Zhu
    • , Abhinav Achreja
    • , Noah Meurs
    • , Olamide Animasahun
    • , Sarah Owen
    • , Anjali Mittal
    • , Pooja Parikh
    • , Ting-Wen Lo
    • , Janusz Franco-Barraza
    • , Jiaqi Shi
    • , Valerie Gunchick
    • , Mara H. Sherman
    • , Edna Cukierman
    • , Andrew M. Pickering
    • , Anirban Maitra
    • , Vaibhav Sahai
    • , Meredith A. Morgan
    • , Sunitha Nagrath
    • , Theodore S. Lawrence
    •  & Deepak Nagrath
  • Letter |

    Cancer cells rely on selenium uptake and selenocysteine biosynthesis to avoid ferroptosis. However, this mechanism makes them dependent on SEPHS2, an enzyme in the selenocysteine biosynthesis pathway for the detoxification selenide that is produced during selenocysteine formation.

    • Anne E. Carlisle
    • , Namgyu Lee
    • , Asia N. Matthew-Onabanjo
    • , Meghan E. Spears
    • , Sung Jin Park
    • , Daniel Youkana
    • , Mihir B. Doshi
    • , Austin Peppers
    • , Rui Li
    • , Alexander B. Joseph
    • , Miles Smith
    • , Karl Simin
    • , Lihua Julie Zhu
    • , Paul L. Greer
    • , Leslie M. Shaw
    •  & Dohoon Kim
  • Perspective |

    The importance of metabolism in the course of SARS-Cov-2 infection is highlighted by the metabolic comorbidities of COVID-19. In this Perspective, Ayres provides insight into how current knowledge of immunometabolism and metabolic diseases can inform the understanding of COVID-19 pathology, and proposes potential metabolism-based clinical solutions.

    • Janelle S. Ayres
  • Letter |

    Maternal exercise, before and during pregnancy, has a beneficial effect on offspring. Harris et al. report that exercise-induced release of oligosaccharide 3′-sialyllactose in mouse breast milk mediates the metabolic health benefits of maternal exercise on offspring by improving glucose and insulin tolerance and cardiac function.

    • Johan E. Harris
    • , Kelsey M. Pinckard
    • , Katherine R. Wright
    • , Lisa A. Baer
    • , Peter J. Arts
    • , Eaman Abay
    • , Vikram K. Shettigar
    • , Adam C. Lehnig
    • , Bianca Robertson
    • , Kendra Madaris
    • , Tyler J. Canova
    • , Clark Sims
    • , Laurie J. Goodyear
    • , Aline Andres
    • , Mark T. Ziolo
    • , Lars Bode
    •  & Kristin I. Stanford
  • Author Correction |

    • Michael Seimetz
    • , Natascha Sommer
    • , Mariola Bednorz
    • , Oleg Pak
    • , Christine Veith
    • , Stefan Hadzic
    • , Marija Gredic
    • , Nirmal Parajuli
    • , Baktybek Kojonazarov
    • , Simone Kraut
    • , Jochen Wilhelm
    • , Fenja Knoepp
    • , Ingrid Henneke
    • , Alexandra Pichl
    • , Zeki I. Kanbagli
    • , Susan Scheibe
    • , Athanasios Fysikopoulos
    • , Cheng-Yu Wu
    • , Walter Klepetko
    • , Peter Jaksch
    • , Christina Eichstaedt
    • , Ekkehard Grünig
    • , Katrin Hinderhofer
    • , Miklós Geiszt
    • , Niklas Müller
    • , Flavia Rezende
    • , Giulia Buchmann
    • , Ilka Wittig
    • , Matthias Hecker
    • , Andreas Hecker
    • , Winfried Padberg
    • , Peter Dorfmüller
    • , Stefan Gattenlöhner
    • , Claus F. Vogelmeier
    • , Andreas Günther
    • , Srikanth Karnati
    • , Eveline Baumgart-Vogt
    • , Ralph T. Schermuly
    • , Hossein A. Ghofrani
    • , Werner Seeger
    • , Katrin Schröder
    • , Friedrich Grimminger
    • , Ralf P. Brandes
    •  & Norbert Weissmann
  • Letter |

    Modulating the capacity of the intestinal epithelium to catabolize fructose is shown to alter fructose-induced lipogenesis in the mouse liver, suggesting that fructose clearance in the small intestine protects from steatosis.

    • Cholsoon Jang
    • , Shogo Wada
    • , Steven Yang
    • , Bridget Gosis
    • , Xianfeng Zeng
    • , Zhaoyue Zhang
    • , Yihui Shen
    • , Gina Lee
    • , Zoltan Arany
    •  & Joshua D. Rabinowitz
  • Viewpoint |

    The transition from senior postdoc to early-stage investigator is a pivotal step in the careers of academic scientists. In this series, early-stage investigators reflect on their labs’ first publications and the journeys that led them there.

    • Lydia Finley
    •  & Lawrence Kazak
  • Article
    | Open Access

    Lymphocytes encounter fluctuations in nutrient availability at sites of infection and inflammation. Wang et al. report that inosine can fulfil the metabolic needs of glucose-restricted anti-tumour effector CD8+ T cells.

    • Tingting Wang
    • , J. N. Rashida Gnanaprakasam
    • , Xuyong Chen
    • , Siwen Kang
    • , Xuequn Xu
    • , Hua Sun
    • , Lingling Liu
    • , Hayley Rodgers
    • , Ethan Miller
    • , Teresa A. Cassel
    • , Qiushi Sun
    • , Sara Vicente-Muñoz
    • , Marc O. Warmoes
    • , Penghui Lin
    • , Zayda Lizbeth Piedra-Quintero
    • , Mireia Guerau-de-Arellano
    • , Kevin A. Cassady
    • , Song Guo Zheng
    • , Jun Yang
    • , Andrew N. Lane
    • , Xiaotong Song
    • , Teresa W.-M. Fan
    •  & Ruoning Wang
  • Article |

    Here, Reilly et al. show that catecholamines control the balance between oxidation and re-esterification of fatty acids in white adipocytes through serine phosphorylation of STAT3, which inhibits the re-esterification enzyme GPAT3 via a non-genomic mechanism.

    • Shannon M. Reilly
    • , Chao-Wei Hung
    • , Maryam Ahmadian
    • , Peng Zhao
    • , Omer Keinan
    • , Andrew V. Gomez
    • , Julia H. DeLuca
    • , Benyamin Dadpey
    • , Donald Lu
    • , Jessica Zaid
    • , BreAnne Poirier
    • , Xiaoling Peng
    • , Ruth T. Yu
    • , Michael Downes
    • , Christopher Liddle
    • , Ronald M. Evans
    • , Anne N. Murphy
    •  & Alan R. Saltiel