Research articles

Wang et al. show how glucose sensing via O-GlcNAcylation drives the assembly of a glycolytic metabolon on the mitochondrial surface to couple metabolic efficiency with neuronal activity.

Adults with overweight or obesity who exercise regularly for at least 2 years exhibit distinct structural and proteomic characteristics in abdominal subcutaneous adipose tissue that may contribute to better cardiometabolic health outcomes.

Buglakova et al. present ¹³C-SpaceM, a method that combines stable isotope tracing with imaging mass spectrometry thus enabling spatial analysis of lipid dynamics with near-single-cell resolution in tissues.

Sukka et al. delineate a metabolic pathway in macrophages that involves tryptophan uptake and metabolism to drive efferocytosis and subsequent resolution in the context of inflammation.

Administration of exogenous mitochondria from mice or humans, or stimulation of mitochondria transfer from haematopoietic cells through bone marrow transplant from wild-type mice, is shown to improve morbidity and mortality in a mouse model of the mitochondrial disease Leigh syndrome.

Grankvist et al. combine global isotopic tracing and metabolic flux modelling to characterize metabolic networks in human intact liver tissue.

Qiu et al. provide insight into the metabolic adaptations that enable breast cancer cells to proliferate in the face of glutaminolysis blockade.

Pancreatic islet β-cells can regulate insulin secretion in vivo, even in the absence of non-β-cells.

Sivanand et al. survey different types of cancers and study how the metabolic profile of the primary cancer site influences the metabolism of the metastatic cells, thus influencing sites of metastasis.

Modest weight gain leads to greater adverse metabolic consequences in South Asian compared to European men, in part driven by differences in adipocyte morphology.

The work deciphers the spatial diversity of neuronal subtypes of the nucleus accumbens shell and identifies a subset of dopamine receptor-expressing neurons marked by Serpinb2 that control food seeking and consumption.

The liver tumour suppressor LIFR plays a key role in liver repair and regeneration by orchestrating cholesterol-driven neutrophil hepatocyte growth factor production and hepatocyte–neutrophil cross-talk.

S-acylation of adipose triacylglyceride lipase, the rate-limiting enzyme of lipolysis, is shown to be required for lipolysis and lipid droplet homoeostasis in mice.

Dietary haem iron intake is linked with a higher type 2 diabetes risk. This dietary association is further supported by circulating metabolic and metabolomic biomarker data.

Multi-omics analysis of mouse livers shows that protein β-hydroxybutyrylation (Kbhb) is strongly affected by the ketogenic diet. Combining bioinformatics with experimental validation, a role of Kbhb sites in modulating mammalian target of rapamycin signalling and cancer cell metabolism is identified.

Saavedra et al. show that broad-spectrum antibiotics impair homeostatic efferocytosis of macrophages in mice by affecting the gut microbiota. Microbial butyrate is shown to rescue homeostatic efferocytosis efficiency in vivo.

In a C. elegans model of defective leucine catabolism, Lee et al. analyse how the complex interplay between host and bacteria rewires metabolism to enable host survival.

Rutter and Benninger discuss the role of putative controlling beta-cell populations in the context of intra-islet connectivity, how such a cellular hierarchy might be achieved and its potential role in islet physiology and diabetes.

The authors identify a neural population in the basal forebrain of mice that is key for maintaining energy balance by facilitating homoeostatic feeding while suppressing hedonic overeating.

Creatine chemical exchange saturation transfer magnetic resonance imaging is used successfully to measure brown adipose tissue activity in rats and humans, delivering data that are consistent with [¹⁸F]fluorodeoxyglucose PET and CT measurements.