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Holst reflects on the development of GLP-1-based drugs for the therapy of obesity, from early observations to remarkable results in more recent clinical trials, discussing physiological, pharmacological and clinical considerations related to their use.
Le Thuc and García-Cáceres discuss the effect of obesity-induced systemic inflammation on the brain, including hypothalamic circuits for whole-body energy homeostasis as well as cognitive function.
The authors provide an update on the most useful biomarkers in urine and blood for assessing food intake, and delineate strategies that may accelerate the application of biomarkers of food intake for improving human nutritional research.
Nguyen and Corvera review distinct changes that occur in adipose tissue during ageing, discuss potential mechanisms by which these changes impact whole-body metabolism, immunity and longevity, and highlight therapeutic opportunities.
Sharma et al. review the regulation and biological functions of apparently ‘futile’ dynamic lipid cycle in regulating whole-body metabolic homeostasis.
Demicco, Liu et al. discuss how metabolic adaptations in cancer contribute to tumour progression. These adaptations entail high spatial and temporal metabolic heterogeneity, based on local adaptations in different regions of the tumour microenvironment, as well as metabolic evolution over time as the tumour progresses and metastasizes.
This Review discusses the role of mitophagy in cellular and organismal health and disease, with a specific focus on human ageing and evidence obtained in clinical studies.
This Review article discusses how the emerging field of metabolomic epidemiology gives insight into the aetiology of various diseases and how these findings could be translated into clinical applications.
Mishra and Townsend present an overview of the regulation, function and plasticity of adipose tissue sensory nerves that are relevant for metabolic processes in health and disease.
In this Review, TeSlaa, Ralser, Fan and Rabinowitz comprehensively review the fundamental biochemical aspects of the pentose phosphate pathway and discuss its biological relevance in the context of physiology and pathology.
Kim and colleagues discuss the regulatory mechanisms of lipogenesis, the physiological and pathological role of lipogenesis in tissues such as adipose tissue, liver, neurons and cancer, and how lipogenesis may be targeted therapeutically to ameliorate disease.
Matsumura, Wei and Sakai discuss epitranscriptomic modifications and their links to metabolic disease, how genetic and environmental factors influence epitranscriptomics, and how the epitranscriptome is linked to the epigenome.
Innate lymphoid cells (ILCs) are an integral part of the innate immune system. This Review discusses how ILC function is regulated by both intrinsic and extrinsic metabolic pathways, and how ILCs contribute to metabolic disease.
Bar-Peled and Kory discuss how metabolic compartmentalization, defined as the spatial and temporal separation of pathways and components within a system, can shape organismal metabolism, while its dysregulation can lead to pathological states.
The author discusses how metabolic engagements and reconfiguration of immune and non-immune cells following virus recognition modulate the natural course of viral infections, and how such early metabolic alterations are likely to influence longer-term disease manifestations of infection.
This Review summarizes emerging concepts for diabetes therapy aimed at specifically altering β cell biology and function, such as β cell insulin signalling, proliferation, differentiation, apoptosis, as well as the selective killing of senescent β cells.
