Review Articles

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  • Innate lymphoid cells (ILCs) are an integral part of the innate immune system. This Review discusses how ILC function is regulated by both intrinsic and extrinsic metabolic pathways, and how ILCs contribute to metabolic disease.

    • Lei Zhou
    • Qingxia Lin
    • Gregory F. Sonnenberg
    Review Article
  • Bar-Peled and Kory discuss how metabolic compartmentalization, defined as the spatial and temporal separation of pathways and components within a system, can shape organismal metabolism, while its dysregulation can lead to pathological states.

    • Liron Bar-Peled
    • Nora Kory
    Review Article
  • The author discusses how metabolic engagements and reconfiguration of immune and non-immune cells following virus recognition modulate the natural course of viral infections, and how such early metabolic alterations are likely to influence longer-term disease manifestations of infection.

    • Clovis. S. Palmer
    Review Article
  • This Review summarizes emerging concepts for diabetes therapy aimed at specifically altering β cell biology and function, such as β cell insulin signalling, proliferation, differentiation, apoptosis, as well as the selective killing of senescent β cells.

    • Chirag Jain
    • Ansarullah
    • Heiko Lickert
    Review Article
  • Measurements of oxygen consumption rates have been central to the resurgent interest in studying cellular metabolism. To enhance the overall reproducibility and reliability of these measurements, Divakaruni and Jastroch provide a guide advising on the selection of experimental models and instrumentation as well as the analysis and interpretation of data.

    • Ajit S. Divakaruni
    • Martin Jastroch
    Review Article
  • The hindbrain is mostly known to participate in eating behaviour by controlling short-term meal parameters and aversive responses to gut malaise. Cheng et al. review current evidence revealing non-aversive neuronal circuits in the hindbrain that are relevant for initiation and termination of homeostatic feeding, as well as for the long-term control of body weight.

    • Wenwen Cheng
    • Desiree Gordian
    • Martin G. Myers Jr.
    Review Article
  • Ozanne and colleagues discuss the evidence of sex differences in the response to suboptimal pre-conceptual and in utero environments, detail the biological mechanisms underlying the intergenerational inheritance of metabolic traits, and show how these sex differences can manifest as metabolic disease in adults.

    • Ionel Sandovici
    • Denise S. Fernandez-Twinn
    • Susan E. Ozanne
    Review Article
  • Zechner and colleagues discuss mechanisms facilitating the mobilization of intracellular fatty acids and how they affect lipid-mediated signalling, metabolic regulation and energy homeostasis in health and disease.

    • Gernot F. Grabner
    • Hao Xie
    • Rudolf Zechner
    Review Article
  • Adipose tissue has emerged as a highly heterogeneous organ. Sun et al. discuss the heterogeneity of thermogenic adipocytes and their precursors, highlighting the single-cell technologies that help to characterize adipose tissues in depth.

    • Wenfei Sun
    • Salvatore Modica
    • Christian Wolfrum
    Review Article
  • Schwartz et al. review mechanisms through which the central nervous system achieves metabolic homeostasis in the basal and postprandial states, and how dysfunction of this integrated central fuel homeostasis control system can contribute to metabolic disease.

    • Martin G. Myers Jr.
    • Alison H. Affinati
    • Michael W. Schwartz
    Review Article
  • Evers et al. explore the interconnection between cellular mechanics and metabolism, emerging paradigms and the role of this interaction in cancer, cardiovascular disease and fibrosis.

    • Tom M. J. Evers
    • Liam J. Holt
    • Alireza Mashaghi
    Review Article
  • Cancer cells undergo metabolic rewiring to support unrestrained proliferation, but dependence on oncogenesis-supportive metabolites could be leveraged therapeutically. Geeraerts et al. explore the centrality of serine and glycine metabolism to cancer survival, and how targeting the de novo serine and glycine synthesis pathways can complement current therapies.

    • Shauni L. Geeraerts
    • Elien Heylen
    • Kim R. Kampen
    Review Article
  • Cellular metabolism has emerged as a major biological node governing cellular behaviour. In their review, Boon et al. explore the mechanisms that maintain nuclear metabolic compartmentalization and the regulation of epigenetics, cell fate and cell physiology by nuclear metabolism.

    • Ruben Boon
    • Giorgia G. Silveira
    • Raul Mostoslavsky
    Review Article
  • Franco et al, review how metabolic insufficiency and prolonged stress responses impact signaling cascades and epigenetic reprogramming to lock T cells into an exhausted state.

    • Fabien Franco
    • Alison Jaccard
    • Ping-Chih Ho
    Review Article
  • Exercise is a powerful modifier of organismal, tissue and cellular metabolism. In their Review, Koelwyn et al. highlight how exercise-induced alterations in the tumour microenvironment can affect immunometabolic mechanisms and how these changes may contribute to the benefits of exercise on cancer initiation and progression.

    • Graeme J. Koelwyn
    • Xueqian Zhuang
    • Lee W. Jones
    Review Article