Review Articles

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  • Sharma et al. review the regulation and biological functions of apparently ‘futile’ dynamic lipid cycle in regulating whole-body metabolic homeostasis.

    • Anand Kumar Sharma
    • Radhika Khandelwal
    • Christian Wolfrum
    Review Article
  • The authors present a holistic view of factors that drive the increasing burden of obesity in Latin America.

    • Sandra Roberta G. Ferreira
    • Yazmín Macotela
    • Marcelo A. Mori
    Review Article
  • Demicco, Liu et al. discuss how metabolic adaptations in cancer contribute to tumour progression. These adaptations entail high spatial and temporal metabolic heterogeneity, based on local adaptations in different regions of the tumour microenvironment, as well as metabolic evolution over time as the tumour progresses and metastasizes.

    • Margherita Demicco
    • Xiao-Zheng Liu
    • Sarah-Maria Fendt
    Review Article
  • This Review discusses the role of mitophagy in cellular and organismal health and disease, with a specific focus on human ageing and evidence obtained in clinical studies.

    • Anna Picca
    • Julie Faitg
    • Davide D’Amico
    Review Article
  • This Review article discusses how the emerging field of metabolomic epidemiology gives insight into the aetiology of various diseases and how these findings could be translated into clinical applications.

    • Harriett Fuller
    • Yiwen Zhu
    • Burcu F. Darst
    Review Article
  • In this Review, TeSlaa, Ralser, Fan and Rabinowitz comprehensively review the fundamental biochemical aspects of the pentose phosphate pathway and discuss its biological relevance in the context of physiology and pathology.

    • Tara TeSlaa
    • Markus Ralser
    • Joshua D. Rabinowitz
    Review Article
  • Kim and colleagues discuss the regulatory mechanisms of lipogenesis, the physiological and pathological role of lipogenesis in tissues such as adipose tissue, liver, neurons and cancer, and how lipogenesis may be targeted therapeutically to ameliorate disease.

    • Yong Geun Jeon
    • Ye Young Kim
    • Jae Bum Kim
    Review Article
  • Matsumura, Wei and Sakai discuss epitranscriptomic modifications and their links to metabolic disease, how genetic and environmental factors influence epitranscriptomics, and how the epitranscriptome is linked to the epigenome.

    • Yoshihiro Matsumura
    • Fan-Yan Wei
    • Juro Sakai
    Review Article
  • Innate lymphoid cells (ILCs) are an integral part of the innate immune system. This Review discusses how ILC function is regulated by both intrinsic and extrinsic metabolic pathways, and how ILCs contribute to metabolic disease.

    • Lei Zhou
    • Qingxia Lin
    • Gregory F. Sonnenberg
    Review Article
  • Bar-Peled and Kory discuss how metabolic compartmentalization, defined as the spatial and temporal separation of pathways and components within a system, can shape organismal metabolism, while its dysregulation can lead to pathological states.

    • Liron Bar-Peled
    • Nora Kory
    Review Article
  • The author discusses how metabolic engagements and reconfiguration of immune and non-immune cells following virus recognition modulate the natural course of viral infections, and how such early metabolic alterations are likely to influence longer-term disease manifestations of infection.

    • Clovis. S. Palmer
    Review Article
  • This Review summarizes emerging concepts for diabetes therapy aimed at specifically altering β cell biology and function, such as β cell insulin signalling, proliferation, differentiation, apoptosis, as well as the selective killing of senescent β cells.

    • Chirag Jain
    • Ansarullah
    • Heiko Lickert
    Review Article
  • Measurements of oxygen consumption rates have been central to the resurgent interest in studying cellular metabolism. To enhance the overall reproducibility and reliability of these measurements, Divakaruni and Jastroch provide a guide advising on the selection of experimental models and instrumentation as well as the analysis and interpretation of data.

    • Ajit S. Divakaruni
    • Martin Jastroch
    Review Article
  • The hindbrain is mostly known to participate in eating behaviour by controlling short-term meal parameters and aversive responses to gut malaise. Cheng et al. review current evidence revealing non-aversive neuronal circuits in the hindbrain that are relevant for initiation and termination of homeostatic feeding, as well as for the long-term control of body weight.

    • Wenwen Cheng
    • Desiree Gordian
    • Martin G. Myers Jr.
    Review Article
  • Ozanne and colleagues discuss the evidence of sex differences in the response to suboptimal pre-conceptual and in utero environments, detail the biological mechanisms underlying the intergenerational inheritance of metabolic traits, and show how these sex differences can manifest as metabolic disease in adults.

    • Ionel Sandovici
    • Denise S. Fernandez-Twinn
    • Susan E. Ozanne
    Review Article
  • Zechner and colleagues discuss mechanisms facilitating the mobilization of intracellular fatty acids and how they affect lipid-mediated signalling, metabolic regulation and energy homeostasis in health and disease.

    • Gernot F. Grabner
    • Hao Xie
    • Rudolf Zechner
    Review Article