Perspectives in 2020

Zhang et al. discuss insights into the genetics of extreme human longevity and how genetics knowledge can be harnessed to guide the development of new therapies to extend human healthspan.

Enerbäck and Rabinowitz summarize emerging evidence that lactate serves as a universal circulating fuel for mammalian cells.

The importance of metabolism in the course of SARS-Cov-2 infection is highlighted by the metabolic comorbidities of COVID-19. In this Perspective, Ayres provides insight into how current knowledge of immunometabolism and metabolic diseases can inform the understanding of COVID-19 pathology, and proposes potential metabolism-based clinical solutions.

He et al. highlight the potential, and some of the drawbacks, of applying single-cell analyses in ageing research.