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  • In this Perspective, the authors discuss the various mouse preclinical models that are available for the study of non-alcoholic steatohepatitis (NASH) and NASH-induced hepatocellular carcinoma, and provide advice on reporting practices and how to select the most appropriate model.

    • Suchira Gallage
    • Jose Efren Barragan Avila
    • Mathias Heikenwalder
  • The authors of this Perspective summarize the state of human islet research and compare available islet procurement methods, proposing strategies to increase collaboration and standardization to accelerate discoveries on diabetes.

    • Anna L. Gloyn
    • Mark Ibberson
    • Michele Solimena
  • In this Perspective, Pekkurnaz and Wang offer an integrative overview on how mitochondrial homeostasis and diversity in morphology, distribution, composition and function contribute to meeting specific cellular demands, with a special focus on neurons

    • Gulcin Pekkurnaz
    • Xinnan Wang
  • Interleukin 6 is a pleiotropic cytokine that can be pro- or anti-inflammatory, depending on the metabolic context. Kistner et al. propose that these context-dependent effects are due to its adaptive role for short-term energy allocation, particularly during physical activity.

    • Timothy M. Kistner
    • Bente K. Pedersen
    • Daniel E. Lieberman
  • Bartman et al. provide a detailed review of techniques for measuring metabolic fluxes in intact mammals, how to analyse and interpret the results and how these techniques can be applied to investigate metabolism in vivo.

    • Caroline R. Bartman
    • Tara TeSlaa
    • Joshua D. Rabinowitz
  • The importance of metabolism in the course of SARS-Cov-2 infection is highlighted by the metabolic comorbidities of COVID-19. In this Perspective, Ayres provides insight into how current knowledge of immunometabolism and metabolic diseases can inform the understanding of COVID-19 pathology, and proposes potential metabolism-based clinical solutions.

    • Janelle S. Ayres
  • Activation of tissue-resident myeloid cells in the brain, known as microglia, is thought to drive obesity-associated hypothalamic dysfunction. The authors of this Perspective present a more nuanced view of microglia, echoing lessons learned from the field of adipose macrophage biology: instead of simply responding to diet-induced damage, microglia are proposed to act as nutrient and environmental sensors that regulate hypothalamic physiology, a role that, if hijacked by chronic overnutrition, can produce disease.

    • Martin Valdearcos
    • Martin G. Myers Jr
    • Suneil K. Koliwad