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  • The immunosuppressive metabolic tumour microenvironment in solid tumours limits the antitumour activity of cell-based immunotherapy. In this Perspective, McPhedran et al. propose a framework to overcome this issue by engineering metabolic networks in T cells to enhance chimeric antigen receptor T cell efficiency

    • Sarah J. McPhedran
    • Gillian A. Carleton
    • Julian J. Lum
  • Lynch and colleagues give an overview of the classical roles of the cytokine IL-17 in host immunity, and look deeper into the emerging roles of IL-17 in cross-talk between the nervous system and gut and how IL-17 regulates and is regulated by systemic metabolic processes.

    • Aaron Douglas
    • Brenneth Stevens
    • Lydia Lynch
  • Cook and colleagues discuss the nature of hepatic insulin resistance and argue that liver hyperinsulinization (excessive hepatic insulin action) is a driver of hepatic steatosis.

    • Joshua R. Cook
    • Meredith A. Hawkins
    • Utpal B. Pajvani
  • The authors of this Perspective argue that the commonly used terms ‘mitochondrial function’ and ‘mitochondrial dysfunction’ do not do justice to the diverse mitochondrial features, activities, functions and behaviours within cells, and thus call for the field to adopt more specific terminology in the context of mitochondrial biology.

    • Anna S. Monzel
    • José Antonio Enríquez
    • Martin Picard
  • The authors provide an overview of the current and emerging wearable and digital devices that can inform about specific metabolic outcomes in people, discussing how they could be used to create more tailored preventive and therapeutic strategies against cardiometabolic disease.

    • Ayya Keshet
    • Lee Reicher
    • Eran Segal
  • In this Perspective, the authors discuss the various mouse preclinical models that are available for the study of non-alcoholic steatohepatitis (NASH) and NASH-induced hepatocellular carcinoma, and provide advice on reporting practices and how to select the most appropriate model.

    • Suchira Gallage
    • Jose Efren Barragan Avila
    • Mathias Heikenwalder
  • The authors of this Perspective summarize the state of human islet research and compare available islet procurement methods, proposing strategies to increase collaboration and standardization to accelerate discoveries on diabetes.

    • Anna L. Gloyn
    • Mark Ibberson
    • Michele Solimena
  • In this Perspective, Pekkurnaz and Wang offer an integrative overview on how mitochondrial homeostasis and diversity in morphology, distribution, composition and function contribute to meeting specific cellular demands, with a special focus on neurons

    • Gulcin Pekkurnaz
    • Xinnan Wang
  • Interleukin 6 is a pleiotropic cytokine that can be pro- or anti-inflammatory, depending on the metabolic context. Kistner et al. propose that these context-dependent effects are due to its adaptive role for short-term energy allocation, particularly during physical activity.

    • Timothy M. Kistner
    • Bente K. Pedersen
    • Daniel E. Lieberman
  • Bartman et al. provide a detailed review of techniques for measuring metabolic fluxes in intact mammals, how to analyse and interpret the results and how these techniques can be applied to investigate metabolism in vivo.

    • Caroline R. Bartman
    • Tara TeSlaa
    • Joshua D. Rabinowitz