Browse Articles

  • Perspective |

    Activation of tissue-resident myeloid cells in the brain, known as microglia, is thought to drive obesity-associated hypothalamic dysfunction. The authors of this Perspective present a more nuanced view of microglia, echoing lessons learned from the field of adipose macrophage biology: instead of simply responding to diet-induced damage, microglia are proposed to act as nutrient and environmental sensors that regulate hypothalamic physiology, a role that, if hijacked by chronic overnutrition, can produce disease.

    • Martin Valdearcos
    • , Martin G. Myers Jr
    •  & Suneil K. Koliwad
  • Article |

    Obesity is associated with an increased risk of colitis-associated cancer (CAC). Here Ostermann et al. show that a high-fat diet induces insulin resistance in intestinal epithelial cells (IECs) and that genetic inactivation of insulin and IGF1 signalling in IECs impairs intestinal regeneration and enhances tumour formation in a CAC mouse model.

    • A. L. Ostermann
    • , C. M. Wunderlich
    • , L. Schneiders
    • , M. C. Vogt
    • , M. A. Woeste
    • , B. F. Belgardt
    • , C. M. Niessen
    • , B. Martiny
    • , A. C. Schauss
    • , P. Frommolt
    • , A. Nikolaev
    • , N. Hövelmeyer
    • , R. C. Sears
    • , P. J. Koch
    • , D. Günzel
    • , J. C. Brüning
    •  & F. T. Wunderlich
  • News & Views |

    Patients with severe diabetes rely on insulin injections to control their blood glucose. A study now provides evidence that human cells that normally do not release insulin can be converted into insulin-producing cells that are able to normalize glycaemia in diabetic mice.

    • Mostafa Bakhti
    •  & Heiko Lickert
  • News & Views |

    The senescence-associated secretory phenotype (SASP) is responsible for the deleterious effects of senescent cells in ageing and cancer. A new study shows that NAD+ metabolism can regulate the pro-inflammatory SASP, thereby promoting tumorigenesis.

    • Pia Pernille Søgaard
    •  & Jesús Gil
  • Letter |

    AMPK is a master regulator of cellular metabolism. Here the authors show that a constitutively active AMPK mutation protects mice fed a high-fat diet from obesity by increasing energy expenditure in subcutaneous white adipocytes, possibly as a result of the emergence of a hitherto-unknown type of adipocyte.

    • Alice E. Pollard
    • , Luís Martins
    • , Phillip J. Muckett
    • , Sanjay Khadayate
    • , Aurélie Bornot
    • , Maryam Clausen
    • , Therese Admyre
    • , Mikael Bjursell
    • , Rebeca Fiadeiro
    • , Laura Wilson
    • , Chad Whilding
    • , Vassilios N. Kotiadis
    • , Michael R. Duchen
    • , Daniel Sutton
    • , Lucy Penfold
    • , Alessandro Sardini
    • , Mohammad Bohlooly-Y
    • , David M. Smith
    • , Jon A. Read
    • , Michael A. Snowden
    • , Angela Woods
    •  & David Carling
  • Article |

    Creatine can be used for thermogenesis in adipocytes. Here Kazak et al. show that creatine uptake is required to sustain this thermogenic pathway. Knockdown of the creatine transporter, CrT, in adipocytes decreases thermogenesis and energy expenditure, whereas creatine supplementation increases energy expenditure in mice fed a high-fat diet.

    • Lawrence Kazak
    • , Janane F. Rahbani
    • , Bozena Samborska
    • , Gina Z. Lu
    • , Mark P. Jedrychowski
    • , Mathieu Lajoie
    • , Song Zhang
    • , LeeAnn Ramsay
    • , Florence Y. Dou
    • , Danielle Tenen
    • , Edward T. Chouchani
    • , Petras Dzeja
    • , Ian R. Watson
    • , Linus Tsai
    • , Evan D. Rosen
    •  & Bruce M. Spiegelman
  • Letter |

    Olfactory food perception is known to extend lifespan in C. elegans. Here the authors demonstrate food-odour-dependent brain-to-gut communication that extends lifespan in worms. Food odour downregulates tir-1 mRNA in AWC neurons, in a manner dependent on the miRNA miR-71, which triggers downstream effects in the gut, due to neuropeptide secretion, that promote proteostasis and longevity.

    • Fabian Finger
    • , Franziska Ottens
    • , Alexander Springhorn
    • , Tanja Drexel
    • , Lucie Proksch
    • , Sophia Metz
    • , Luisa Cochella
    •  & Thorsten Hoppe
  • Review Article |

    Like stem cells, cancer cells can rapidly proliferate but, unlike stem cells, they are mostly locked into a malignant identity. Here, Finley and Intlekofer highlight commonalities in anabolic pathways that support proliferation in cancer and stem cells, and point out unique metabolic features that influence self-renewal and differentiation.

    • Andrew M. Intlekofer
    •  & Lydia W. S. Finley
  • Article |

    Many beneficial effects of exercise are mediated by factors secreted from the exercising muscle, so-called myokines. Here, the authors identify what might be the first exercised-induced adipokine, TGF-β2, which is secreted from subcutaneous fat in response to exercise-induced increases in serum lactate levels and has beneficial metabolic effects in mice.

    • Hirokazu Takahashi
    • , Christiano R. R. Alves
    • , Kristin I. Stanford
    • , Roeland J. W. Middelbeek
    • , Pasquale Nigro
    • , Rebecca E. Ryan
    • , Ruidan Xue
    • , Masaji Sakaguchi
    • , Matthew D. Lynes
    • , Kawai So
    • , Joram D. Mul
    • , Min-Young Lee
    • , Estelle Balan
    • , Hui Pan
    • , Jonathan M. Dreyfuss
    • , Michael F. Hirshman
    • , Mohamad Azhar
    • , Jarna C. Hannukainen
    • , Pirjo Nuutila
    • , Kari K. Kalliokoski
    • , Søren Nielsen
    • , Bente K. Pedersen
    • , C. Ronald Kahn
    • , Yu-Hua Tseng
    •  & Laurie J. Goodyear
  • Letter |

    Neurons and astrocytes cooperate metabolically but differ in key aspects of their metabolism, including the production of mitochondrial reactive oxygen species (ROS). Here, the authors show that mitochondrial ROS produced in astrocytes affect neuronal metabolism and mouse memory and behaviour.

    • Carlos Vicente-Gutierrez
    • , Nicoló Bonora
    • , Veronica Bobo-Jimenez
    • , Daniel Jimenez-Blasco
    • , Irene Lopez-Fabuel
    • , Emilio Fernandez
    • , Charlene Josephine
    • , Gilles Bonvento
    • , Jose A. Enriquez
    • , Angeles Almeida
    •  & Juan P. Bolaños
  • News & Views |

    Hypothalamic neuronal diversity is at the core of whole-body energy-homeostasis control, but the molecular mechanisms governing neuronal neuropeptide specification remain incompletely understood. A new study in Nature Metabolism adds a relevant piece to the puzzle of how key hypothalamic neuronal populations maintain their peptidergic identity throughout the lifespan.

    • Arnaud Obri
    •  & Marc Claret
  • Article |

    Hypothalamic melanocortin neurons control energy homoeostasis by modulating appetite. Here, the authors reveal a role for the transcription factor Tbx3 as a regulator of the peptidergic identity and function of immature and mature mouse melanocortin neurons.

    • Carmelo Quarta
    • , Alexandre Fisette
    • , Yanjun Xu
    • , Gustav Colldén
    • , Beata Legutko
    • , Yu-Ting Tseng
    • , Alexander Reim
    • , Michael Wierer
    • , Maria Caterina De Rosa
    • , Valentina Klaus
    • , Rick Rausch
    • , Vidhu V. Thaker
    • , Elisabeth Graf
    • , Tim M. Strom
    • , Anne-Laure Poher
    • , Tim Gruber
    • , Ophélia Le Thuc
    • , Alberto Cebrian-Serrano
    • , Dhiraj Kabra
    • , Luigi Bellocchio
    • , Stephen C. Woods
    • , Gert O. Pflugfelder
    • , Rubén Nogueiras
    • , Lori Zeltser
    • , Ilona C. Grunwald Kadow
    • , Anne Moon
    • , Cristina García-Cáceres
    • , Matthias Mann
    • , Mathias Treier
    • , Claudia A. Doege
    •  & Matthias H. Tschöp
  • News & Views |

    The circulatory system in long bones is incompletely understood. A new study published in Nature Metabolism unveils the presence of dense vascular networks in long bones that facilitate the egress of bone marrow cells and potentially the exchange of nutrients between the bone marrow and the systemic circulation.

    • Christopher Ritchlin
    •  & Iannis E. Adamopoulos
  • Article |

    Bone marrow-derived cells can rapidly enter the systemic circulation, but how this is achieved is unclear. Grüneboom et al. identify tiny capillaries, termed trans-cortical vessels (TCVs), that connect the bone marrow cavity to the systemic vasculature, and show that the majority of blood in long bones passes through TCVs.

    • Anika Grüneboom
    • , Ibrahim Hawwari
    • , Daniela Weidner
    • , Stephan Culemann
    • , Sylvia Müller
    • , Sophie Henneberg
    • , Alexandra Brenzel
    • , Simon Merz
    • , Lea Bornemann
    • , Kristina Zec
    • , Manuela Wuelling
    • , Lasse Kling
    • , Mike Hasenberg
    • , Sylvia Voortmann
    • , Stefanie Lang
    • , Wolfgang Baum
    • , Alexandra Ohs
    • , Oliver Kraff
    • , Harald H. Quick
    • , Marcus Jäger
    • , Stefan Landgraeber
    • , Marcel Dudda
    • , Renzo Danuser
    • , Jens V. Stein
    • , Manfred Rohde
    • , Kolja Gelse
    • , Annette I. Garbe
    • , Alexandra Adamczyk
    • , Astrid M. Westendorf
    • , Daniel Hoffmann
    • , Silke Christiansen
    • , Daniel Robert Engel
    • , Andrea Vortkamp
    • , Gerhard Krönke
    • , Martin Herrmann
    • , Thomas Kamradt
    • , Georg Schett
    • , Anja Hasenberg
    •  & Matthias Gunzer
  • Review Article |

    Adipose tissue responds to a variety of hormonal and environmental cues with changes in size, cellular composition and metabolic activity. Here Kajimura and Chouchani review our current understanding of adipocyte metabolism in physiology and metabolic disease, and they discuss strategies to reprogram adipocyte fate and metabolism.

    • Edward T. Chouchani
    •  & Shingo Kajimura
  • Letter |

    Perineuronal nets (PNNs) are extracellular matrix structures that have been linked to neuronal plasticity in the cortex and hippocampus. Here, the authors report the existence of PNN-like structures in a key region regulating energy homoeostasis, the hypothalamic arcuate nucleus, and show that PNN formation in this area early in life is influenced by the hormone leptin.

    • Zaman Mirzadeh
    • , Kimberly M. Alonge
    • , Elaine Cabrales
    • , Vicente Herranz-Pérez
    • , Jarrad M. Scarlett
    • , Jenny M. Brown
    • , Rim Hassouna
    • , Miles E. Matsen
    • , Hong T. Nguyen
    • , Jose Manuel Garcia-Verdugo
    • , Lori M. Zeltser
    •  & Michael W. Schwartz
  • Article |

    ACC1 is a rate-limiting enzyme during fatty acid biosynthesis. Here the authors describe how loss of ACC1 enhances CD4+ memory T cell formation and improves outcome in a murine model of parasite infection, indicating that lipid biosynthesis directs cell-fate determination during the generation of memory T cells.

    • Yusuke Endo
    • , Atsushi Onodera
    • , Kazushige Obata-Ninomiya
    • , Ryo Koyama-Nasu
    • , Hikari K. Asou
    • , Toshihiro Ito
    • , Takeshi Yamamoto
    • , Toshio Kanno
    • , Takahiro Nakajima
    • , Kenji Ishiwata
    • , Hirotaka Kanuka
    • , Damon J. Tumes
    •  & Toshinori Nakayama
  • Article |

    As opposed to circulating factors that promote energy expenditure, hormones that suppress energy expenditure have remained largely elusive. Here, Wang et al. show that the hepatokine Tsukushi is upregulated in obesity and inhibits sympathetic activity and thermogenesis in fat by promoting whitening.

    • Qiuyu Wang
    • , Vishal P. Sharma
    • , Hong Shen
    • , Yuanyuan Xiao
    • , Qi Zhu
    • , Xuelian Xiong
    • , Liang Guo
    • , Lin Jiang
    • , Kunimasa Ohta
    • , Siming Li
    • , Haifei Shi
    • , Liangyou Rui
    •  & Jiandie D. Lin
  • Article |

    Ageing is associated with deteriorating immune function and metabolic diseases. Here, the authors show that plasma levels of the stress-response protein MANF decline with age in various organisms and that MANF has beneficial effects on immune and metabolic function, particularly in the liver, in old mice.

    • Pedro Sousa-Victor
    • , Joana Neves
    • , Wendy Cedron-Craft
    • , P. Britten Ventura
    • , Chen-Yu Liao
    • , Rebeccah R. Riley
    • , Ilya Soifer
    • , Nicholas van Bruggen
    • , Ganesh A. Kolumam
    • , Saul A. Villeda
    • , Deepak A. Lamba
    •  & Heinrich Jasper
  • Review Article |

    The gut microbiome has emerged as an important regulator of host physiology and disease, including metabolic diseases. Here Cani et al. provide a broad overview of mechanisms through which the gut microbiota affects metabolic regulation in the host.

    • Patrice D. Cani
    • , Matthias Van Hul
    • , Charlotte Lefort
    • , Clara Depommier
    • , Marialetizia Rastelli
    •  & Amandine Everard
  • Article |

    Transferrin receptor 2 (Trf2) is known to regulate iron homeostasis through its action in the liver. Here the authors report a previously unrecognised role of Trf2 in regulating bone homeostasis mediated by modulation of BMP signalling specifically on osteoblasts.

    • Martina Rauner
    • , Ulrike Baschant
    • , Antonella Roetto
    • , Rosa Maria Pellegrino
    • , Sandra Rother
    • , Juliane Salbach-Hirsch
    • , Heike Weidner
    • , Vera Hintze
    • , Graeme Campbell
    • , Andreas Petzold
    • , Regis Lemaitre
    • , Ian Henry
    • , Teresita Bellido
    • , Igor Theurl
    • , Sandro Altamura
    • , Silvia Colucci
    • , Martina U. Muckenthaler
    • , Georg Schett
    • , Davide S. K. Komla-Ebri
    • , J. H. Duncan Bassett
    • , Graham R. Williams
    • , Uwe Platzbecker
    •  & Lorenz C. Hofbauer
  • Article |

    Endothelial cells (ECs) require glycolysis during angiogenesis; however, the function of the mitochondrial respiratory chain during this process is unclear. Here the authors show that mitochondrial respiration in ECs is required for angiogenesis as the biosynthetic role of mitochondria is needed for EC proliferation.

    • Lauren P. Diebold
    • , Hyea Jin Gil
    • , Peng Gao
    • , Carlos A. Martinez
    • , Samuel E. Weinberg
    •  & Navdeep S. Chandel
  • Article |

    Extracellular matrix (ECM) homeostasis is essential for normal tissue function, and its perturbation by injury, trauma or disease results in fibrosis. Here, the authors show that glycolysis and the fatty acid oxidation pathway regulate fibroblast behaviour and have reciprocal effects in ECM upregulation and downregulation, respectively.

    • Xiao Zhao
    • , Pamela Psarianos
    • , Laleh Soltan Ghoraie
    • , Kenneth Yip
    • , David Goldstein
    • , Ralph Gilbert
    • , Ian Witterick
    • , Hilary Pang
    • , Ali Hussain
    • , Ju Hee Lee
    • , Justin Williams
    • , Scott V. Bratman
    • , Laurie Ailles
    • , Benjamin Haibe-Kains
    •  & Fei-Fei Liu
  • News & Views |

    Strategies to restore levels of the enzyme cofactor nicotinamide adenine dinclueotide (NAD) late in life to maintain health by treatment with NAD precursors, such as nicotinamide mononucleotide (NMN), represent an exciting area of research in aging and age-related diseases. A study in Nature Metabolism provides an answer to the hotly debated yet fundamental question: how NMN actually gets into cells.

    • Lindsay E. Wu
    •  & David A. Sinclair
  • Comment |

    Over the past decade, the field of metabolism has witnessed remarkable scientific discoveries that reshaped the understanding of metabolic physiology and disease. As we launch Nature Metabolism, we look at what the future holds for metabolic research.

    • Fredrik Bäckhed
    • , Elisabetta Bugianesi
    • , Heather Christofk
    • , Ivan Dikic
    • , Rana Gupta
    • , William B. Mair
    • , Luke A. J. O’Neill
    • , Markus Ralser
    • , David M. Sabatini
    •  & Matthias Tschöp
  • Comment |

    Many commonly used inbred mouse strains carry random mutations that can affect the results of metabolic studies. Yet, awareness of such mutations as a source for experimental variation and seemingly contradictory results is lacking. It is time that scientists pay more attention to the identification, tracking and accurate reporting of mouse strains used in experiments.

    • José Antonio Enríquez
  • Article |

    Despite the similarity of metabolic flux patterns in different organisms, the underlying governing principles remain unclear. Using a constraint-based thermodynamic–stoichiometric model as well as quantitative metabolome and physiological data, Niebel et al. identify an upper limit on the cellular Gibbs energy dissipation rate, which could shape metabolism across organisms.

    • Bastian Niebel
    • , Simeon Leupold
    •  & Matthias Heinemann
  • News & Views |

    Fibrosis is characterized by excessive extracellular matrix (ECM) production relative to catabolism. A new study shows that the fuel choice of fibroblasts impacts this balance, with glycolysis promoting ECM synthesis and fatty acid oxidation stimulating ECM degradation.

    • Joshua D. Rabinowitz
    •  & Gökhan M. Mutlu
  • Article |

    Nicotinamide mononucleotide (NMN) is a biosynthetic precursor of NAD+, but how NMN is taken up into cells has not been entirely clear. Here the authors discover a specific NMN transporter, encoded by the Slc12a8 gene, which regulates NMN uptake and cellular NAD+ levels in vitro and in the mouse intestine in vivo.

    • Alessia Grozio
    • , Kathryn F. Mills
    • , Jun Yoshino
    • , Santina Bruzzone
    • , Giovanna Sociali
    • , Kyohei Tokizane
    • , Hanyue Cecilia Lei
    • , Richard Cunningham
    • , Yo Sasaki
    • , Marie E. Migaud
    •  & Shin-ichiro Imai
  • News & Views |

    The growth of new blood vessels (angiogenesis) is a bio-energetically demanding process. Surprisingly, the specific role of mitochondria in angiogenesis remains unclear. A study in this issue of Nature Metabolism now demonstrates that mitochondrial respiration is essential for angiogenic growth by controlling endothelial proliferation.

    • Jorge Andrade
    •  & Michael Potente
  • Editorial |

    Today, we are proud to launch Nature Metabolism, a new dedicated home for exciting research and commentary that spans the spectrum of metabolism research.

  • Review Article |

    Intermediate metabolites of the Krebs cycle serve bioenergetic and biosynthetic needs but have recently also been linked to signalling. The authors of this Review summarize such non-metabolic signalling functions of succinate, fumarate, itaconate, 2-hydroxyglutarate isomers and acetyl-CoA in both immune cells and cancer cells.

    • Dylan G. Ryan
    • , Michael P. Murphy
    • , Christian Frezza
    • , Hiran A. Prag
    • , Edward T. Chouchani
    • , Luke A. O’Neill
    •  & Evanna L. Mills
  • News & Views |

    Cholesterol accumulation in cells and blood vessels promotes the development of vascular diseases. The long non-coding RNA CHROME can help clear excess cholesterol and provide protection from atherosclerosis.

    • Tamer Sallam
    •  & Peter Tontonoz
  • Article |

    Maintenance of cholesterol homeostasis is essential to human health. Here, the authors identify and characterize a primate-specific long noncoding RNA, called CHROME, that controls cholesterol homeostasis through fine-tuning of miRNAs and whose levels are elevated in human atherosclerosis.

    • Elizabeth J. Hennessy
    • , Coen van Solingen
    • , Kaitlyn R. Scacalossi
    • , Mireille Ouimet
    • , Milessa S. Afonso
    • , Jurrien Prins
    • , Graeme J. Koelwyn
    • , Monika Sharma
    • , Bhama Ramkhelawon
    • , Susan Carpenter
    • , Albert Busch
    • , Ekaterina Chernogubova
    • , Ljubica Perisic Matic
    • , Ulf Hedin
    • , Lars Maegdefessel
    • , Brian E. Caffrey
    • , Maryem A. Hussein
    • , Emiliano P. Ricci
    • , Ryan E. Temel
    • , Michael J. Garabedian
    • , Jeffrey S. Berger
    • , Kasey C. Vickers
    • , Matthew Kanke
    • , Praveen Sethupathy
    • , Daniel Teupser
    • , Lesca M. Holdt
    •  & Kathryn J. Moore
  • Article |

    Impaired adipocyte insulin signalling characterizes insulin resistance. Here the authors show that the hormone-sensitive lipase can sequester the glucose-responsive transcription factor ChREBP in the cytoplasm, which prevents transcription of its target ELOVL6, resulting in reduced insulin signalling.

    • Pauline Morigny
    • , Marianne Houssier
    • , Aline Mairal
    • , Claire Ghilain
    • , Etienne Mouisel
    • , Fadila Benhamed
    • , Bernard Masri
    • , Emeline Recazens
    • , Pierre-Damien Denechaud
    • , Geneviève Tavernier
    • , Sylvie Caspar-Bauguil
    • , Sam Virtue
    • , Veronika Sramkova
    • , Laurent Monbrun
    • , Anne Mazars
    • , Madjid Zanoun
    • , Sandra Guilmeau
    • , Valentin Barquissau
    • , Diane Beuzelin
    • , Sophie Bonnel
    • , Marie Marques
    • , Boris Monge-Roffarello
    • , Corinne Lefort
    • , Barbara Fielding
    • , Thierry Sulpice
    • , Arne Astrup
    • , Bernard Payrastre
    • , Justine Bertrand-Michel
    • , Emmanuelle Meugnier
    • , Laetitia Ligat
    • , Frédéric Lopez
    • , Hervé Guillou
    • , Charlotte Ling
    • , Cecilia Holm
    • , Remi Rabasa-Lhoret
    • , Wim H. M. Saris
    • , Vladimir Stich
    • , Peter Arner
    • , Mikael Rydén
    • , Cedric Moro
    • , Nathalie Viguerie
    • , Matthew Harms
    • , Stefan Hallén
    • , Antonio Vidal-Puig
    • , Hubert Vidal
    • , Catherine Postic
    •  & Dominique Langin
  • Article |

    The metabolic dependencies of androgen receptor (AR)-driven growth in prostate adenocarcinoma are largely unknown but could represent a therapeutic target when hormonal manipulations fail. Here the authors demonstrate that the mitochondrial pyruvate carrier (MPC) is transcriptionally regulated by AR and that MPC inhibition suppresses tumour growth in hormone-responsive and castrate-resistant conditions.

    • David A. Bader
    • , Sean M. Hartig
    • , Vasanta Putluri
    • , Christopher Foley
    • , Mark P. Hamilton
    • , Eric A. Smith
    • , Pradip K. Saha
    • , Anil Panigrahi
    • , Christopher Walker
    • , Lin Zong
    • , Heidi Martini-Stoica
    • , Rui Chen
    • , Kimal Rajapakshe
    • , Cristian Coarfa
    • , Arun Sreekumar
    • , Nicholas Mitsiades
    • , James A. Bankson
    • , Michael M. Ittmann
    • , Bert W. O’Malley
    • , Nagireddy Putluri
    •  & Sean E. McGuire
  • Article |

    Obese and dysfunctional adipose tissue is known to be hypoxic. Here the authors show that adipocyte oxygen consumption increases early after onset of high-fat diet feeding owing to activation of the mitochondrial protein ANT2 and that specific inhibition of ANT2 reduces adipose tissue hypoxia, inflammation and insulin resistance.

    • Jong Bae Seo
    • , Matthew Riopel
    • , Pedro Cabrales
    • , Jin Young Huh
    • , Gautam K. Bandyopadhyay
    • , Aleksander Yu Andreyev
    • , Anne N. Murphy
    • , Scott C. Beeman
    • , Gordon I. Smith
    • , Samuel Klein
    • , Yun Sok Lee
    •  & Jerrold M. Olefsky
  • Article |

    Glucose-dependent insulinotropic polypeptide (GIP) is a gut incretin hormone released in response to nutrients. Here, the authors report an anti-inflammatory and antiobesogenic mechanism of GIP by showing that loss of GIP receptor signalling in myeloid cells promotes pro-inflammatory S100A8/A9 release in adipose tissue.

    • Fernanda Dana Mantelmacher
    • , Isabel Zvibel
    • , Keren Cohen
    • , Alona Epshtein
    • , Metsada Pasmanik-Chor
    • , Thomas Vogl
    • , Yael Kuperman
    • , Shai Weiss
    • , Daniel J. Drucker
    • , Chen Varol
    •  & Sigal Fishman