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  • Evers et al. explore the interconnection between cellular mechanics and metabolism, emerging paradigms and the role of this interaction in cancer, cardiovascular disease and fibrosis.

    • Tom M. J. Evers
    • Liam J. Holt
    • Alireza Mashaghi
    Review Article
  • Colchicine is an anti-inflammatory agent that suppresses myeloid cell activation and is commonly used to treat gout. In this issue of Nature Metabolism, Weng et al. demonstrate that colchicine exerts its anti-inflammatory effects in mice via the induction of the hormone GDF-15 in the liver.

    • Samuel M. Lockhart
    • Stephen O’Rahilly
    News & Views
  • Brown adipose tissue acquires increased thermogenic capacity with prolonged cold exposure through de novo recruitment of brown adipocytes. Studies by Shamsi et al. and Angueira et al. identify novel cellular origins of cold-induced brown adipocytes and further elucidate the molecular mechanism regulating the expansion of brown adipose tissue.

    • Alana Deutsch
    • Kosaku Shinoda
    News & Views
  • Redox cofactors are essential for the metabolic reactions that support cell proliferation. NADPH is important both to combat oxidative stress and to facilitate reductive reactions in biosynthesis. In this issue, Tran et al. find that the enzyme that produces mitochondrial NADPH is critical in enabling proline synthesis to support cell proliferation when environmental proline is limited.

    • Frances F. Diehl
    • Matthew G. Vander Heiden
    News & Views
  • Learning to balance work, family, optimism and setbacks is a process for all early-career investigators. Stephanie Correa and Leng Han share their stories in this instalment of Career pathways.

    • Stephanie Correa
    • Leng Han
    Viewpoint
  • Obesity is associated with mitochondrial dysfunction and chronic metabolic derailment. Cho et al. report that elevated adipose expression of the Hippo kinases STK3 and STK4 (STK3/4) in obesity and type 2 diabetes decreases the mass and oxidative capacity of adipocyte mitochondria. Genetic or pharmacological inhibition of STK3/4 restores mitochondrial mass and function in adipocytes and improves glucose homeostasis in mice with diet-induced obesity. These findings support STK3/4 as new targets for obesity-related diseases.

    • Kathrin Maedler
    • Amin Ardestani
    News & Views
  • Cho et al. show regulation of mitophagy, and thereby energy expenditure, in adipocytes by the Hippo pathway kinases STK3 and STK4, independently of classical Hippo signalling. Genetic inactivation of Stk3 and Stk4 is shown to protect mice from the adverse metabolic effects of diet-induced obesity.

    • Yoon Keun Cho
    • Yeonho Son
    • Yun-Hee Lee
    Article
  • It is self-evident that consuming alcohol affects brain function and behaviour. What is not clear, however, is how alcohol does so. A new study shows that impairments in balance and motor coordination evoked by low-dose alcohol are mediated not by ethanol itself but by one of its metabolites, which is produced locally by astrocytes in the brain rather than in the liver.

    • Riccardo Melani
    • Nicolas X. Tritsch
    News & Views