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The HDL receptor enhances SARS-CoV-2 cellular entry

Latest Issue

  • Comment |

    • Shoval Lagziel
    • , Eyal Gottlieb
    •  & Tomer Shlomi
  • Letter |

    • Susanna Raho
    • , Loredana Capobianco
    • , Rocco Malivindi
    • , Angelo Vozza
    • , Carmela Piazzolla
    • , Francesco De Leonardis
    • , Ruggiero Gorgoglione
    • , Pasquale Scarcia
    • , Francesca Pezzuto
    • , Gennaro Agrimi
    • , Simona N. Barile
    • , Isabella Pisano
    • , Stephan J. Reshkin
    • , Maria R. Greco
    • , Rosa A. Cardone
    • , Vittoria Rago
    • , Yuan Li
    • , Carlo M. T. Marobbio
    • , Wolfgang Sommergruber
    • , Christopher L. Riley
    • , Francesco M. Lasorsa
    • , Edward Mills
    • , Maria C. Vegliante
    • , Giuseppe E. De Benedetto
    • , Deborah Fratantonio
    • , Luigi Palmieri
    • , Vincenza Dolce
    •  & Giuseppe Fiermonte
  • Article |

    • Congwen Wei
    • , Luming Wan
    • , Qiulin Yan
    • , Xiaolin Wang
    • , Jun Zhang
    • , Xiaopan Yang
    • , Yanhong Zhang
    • , Chen Fan
    • , Dongyu Li
    • , Yongqiang Deng
    • , Jin Sun
    • , Jing Gong
    • , Xiaoli Yang
    • , Yufei Wang
    • , Xuejun Wang
    • , Jianmin Li
    • , Huan Yang
    • , Huilong Li
    • , Zhe Zhang
    • , Rong Wang
    • , Peng Du
    • , Yulong Zong
    • , Feng Yin
    • , Wanchuan Zhang
    • , Nan Wang
    • , Yumeng Peng
    • , Haotian Lin
    • , Jiangyue Feng
    • , Chengfeng Qin
    • , Wei Chen
    • , Qi Gao
    • , Rui Zhang
    • , Yuan Cao
    •  & Hui Zhong
  • Article |

    • Yu-Hsi Lin
    • , Nikunj Satani
    • , Naima Hammoudi
    • , Victoria C. Yan
    • , Yasaman Barekatain
    • , Sunada Khadka
    • , Jeffrey J. Ackroyd
    • , Dimitra K. Georgiou
    • , Cong-Dat Pham
    • , Kenisha Arthur
    • , David Maxwell
    • , Zhenghong Peng
    • , Paul G. Leonard
    • , Barbara Czako
    • , Federica Pisaneschi
    • , Pijus Mandal
    • , Yuting Sun
    • , Rafal Zielinski
    • , Susana Castro Pando
    • , Xiaobo Wang
    • , Theresa Tran
    • , Quanyu Xu
    • , Qi Wu
    • , Yongying Jiang
    • , Zhijun Kang
    • , John M. Asara
    • , Waldemar Priebe
    • , William Bornmann
    • , Joseph R. Marszalek
    • , Ronald A. DePinho
    •  & Florian L. Muller

Nature Metabolism is a Transformative Journal; authors can publish using the traditional publishing route OR Open Access.
Our Open Access option complies with funder and institutional requirements.

Latest Research

  • Article |

    Xu et al. show that liver ATF3 expression is inhibited by hydrocortisone, thus promoting the development of atherosclerosis through effects on HDL cholesterol and bile acid metabolism.

    • Yanyong Xu
    • , Yuanyuan Li
    • , Kavita Jadhav
    • , Xiaoli Pan
    • , Yingdong Zhu
    • , Shuwei Hu
    • , Shaoru Chen
    • , Liuying Chen
    • , Yong Tang
    • , Helen H. Wang
    • , Ling Yang
    • , David Q.-H. Wang
    • , Liya Yin
    •  & Yanqiao Zhang
  • Letter |

    In an unbiased screen, Perry et al. find that tetracycline antibiotics improve resilience of cultured cells carrying disease-associated mitochondrial DNA mutations. Doxycycline is shown to increases survival, and reduce symptoms, in a mouse model of Leigh syndrome.

    • Elizabeth A. Perry
    • , Christopher F. Bennett
    • , Chi Luo
    • , Eduardo Balsa
    • , Mark Jedrychowski
    • , Katherine E. O’Malley
    • , Pedro Latorre-Muro
    • , Richard Porter Ladley
    • , Kamar Reda
    • , Peter M. Wright
    • , Steven P. Gygi
    • , Andrew G. Myers
    •  & Pere Puigserver
  • Article |

    Creatine availability is known to affect creatine-driven thermogenesis in mice. Here Connell et al. report data from a clinical trial in which daily creatine supplementation, perhaps surprisingly, did not alter thermogenesis in adults with otherwise low dietary creatine intake.

    • Niels J. Connell
    • , Daniel Doligkeit
    • , Charlotte Andriessen
    • , Esther Kornips-Moonen
    • , Yvonne M. H. Bruls
    • , Vera B. Schrauwen-Hinderling
    • , Tineke van de Weijer
    • , Wouter D. van Marken-Lichtenbelt
    • , Bas Havekes
    • , Lawrence Kazak
    • , Bruce M. Spiegelman
    • , Joris Hoeks
    •  & Patrick Schrauwen
  • Metabolic Messengers |

    Gribble and Reimann provide a concise overview of the core physiology of GLP-1 secretion and action, and the roles of GLP-1 in human health, disease and therapy.

    • Fiona M. Gribble
    •  & Frank Reimann
  • Article |

    Previously, liver zonation was analysed statically, and liver chronobiology was analysed at the tissue level. Using single-cell RNA-seq and single-molecule FISH, Droin et al. study the interplay between liver gene regulation in space and time at the sub-lobular scale.

    • Colas Droin
    • , Jakob El Kholtei
    • , Keren Bahar Halpern
    • , Clémence Hurni
    • , Milena Rozenberg
    • , Sapir Muvkadi
    • , Shalev Itzkovitz
    •  & Felix Naef

News & Comment

  • News & Views |

    Mitochondrial diseases are caused by genetic variants in either nuclear or mitochondrial DNA, and they have no known treatments. A new study by Perry et al. in this issue of Nature Metabolism used a drug screen to identify the widely available antibiotic doxycycline, an inhibitor of mitochondrial translation, as a potential pharmacological treatment for mitochondrial diseases.

    • Divakar S. Mithal
    •  & Navdeep S. Chandel
  • News & Views |

    A creatine futile cycle has been shown to contribute to energy expenditure in beige adipocytes in preclinical mouse models of obesity. In this issue of Nature Metabolism, Connell and colleagues show that creatine supplementation in healthy young female vegetarians unfortunately affects neither human brown adipocyte activity nor cold-induced energy expenditure.

    • Salvatore Modica
    •  & Christian Wolfrum
  • News & Views |

    Liver function depends on the temporal and zonal distribution of complementary metabolic tasks in hepatocytes. A new study by Droin et al. highlights how chronobiology and liver zonation orchestrate liver metabolism at single-cell resolution.

    • Stefano Annunziato
    •  & Jan S. Tchorz
  • Comment |

    The prevalence of COVID-19-associated diabetes is not the result of a single event but of a combination of disease susceptibility associated with chronic illness and COVID-19-specific mechanisms affecting metabolism. Whether a separate entity of post-COVID-19 diabetes, possibly associated with lasting β-cell damage, also exists is not yet clear.

    • Domenico Accili
  • News & Views |

    The restoration of the progressive decline in nicotinamide adenine dinucleotide (NAD+) levels mitigates certain age-associated dysfunctions. A fundamental question is how the NAD+-consuming enzyme CD38 decreases NAD+ levels during ageing. Two new studies by Chini et al. and Covarrubias et al. in this issue of Nature Metabolism show that CD38 expression in macrophages induced by senescence-associated inflammation accounts for the age-related decline in NAD+ levels.

    • Shuai Wu
    •  & Rugang Zhang
  • News & Views |

    A new global measure of cell-to-cell transcriptional variability from single-cell RNA-sequencing data has been developed by Levy et al., on the basis of the transcriptional interrelations between genes. The new variable, termed global coordination level, decreases with age in different organisms and cell types and correlates with high mutational load in cells.

    • Jan Vijg