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Tonic-ing emissions and compatibility to turbocharge CAR-T
Optimization of energy and carbon–nitrogen allocation maximizes the proliferation and functionality of chimeric antigen receptor (CAR)-T cells. Lakhani et al. report that tonic signalling elements (scFvs) affect CAR-T cell metabolic fitness in an antigen-independent manner. A modest carbon–nitrogen emission (overflow) and resilient metabolic phenotype (compatibility) are associated with effective CAR-T cell therapy.
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Systemic proteome adaptions to 7-day complete caloric restriction in humans
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Trigonelline is an NAD+ precursor that improves muscle function during ageing and is reduced in human sarcopenia
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A call for accessible tools to unlock single-cell immunometabolism research
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Gastric mechanosensitive channel Piezo1 regulates ghrelin production and food intake