Launching January 2019

Launching in 2019, Nature Metabolism is an online-only journal publishing content across the full spectrum of Metabolism research, from basic science studies to biomedical and translational research.

Browse Articles

  • Nat. Metab. | News & Views |

    Cholesterol accumulation in cells and blood vessels promotes the development of vascular diseases. The long non-coding RNA CHROME can help clear excess cholesterol and provide protection from atherosclerosis.

    • Tamer Sallam
    •  & Peter Tontonoz
  • Nat. Metab. | Article |

    Maintenance of cholesterol homeostasis is essential to human health. Here, the authors identify and characterize a primate-specific long noncoding RNA, called CHROME, that controls cholesterol homeostasis through fine-tuning of miRNAs and whose levels are elevated in human atherosclerosis.

    • Elizabeth J. Hennessy
    • , Coen van Solingen
    • , Kaitlyn R. Scacalossi
    • , Mireille Ouimet
    • , Milessa S. Afonso
    • , Jurrien Prins
    • , Graeme J. Koelwyn
    • , Monika Sharma
    • , Bhama Ramkhelawon
    • , Susan Carpenter
    • , Albert Busch
    • , Ekaterina Chernogubova
    • , Ljubica Perisic Matic
    • , Ulf Hedin
    • , Lars Maegdefessel
    • , Brian E. Caffrey
    • , Maryem A. Hussein
    • , Emiliano P. Ricci
    • , Ryan E. Temel
    • , Michael J. Garabedian
    • , Jeffrey S. Berger
    • , Kasey C. Vickers
    • , Matthew Kanke
    • , Praveen Sethupathy
    • , Daniel Teupser
    • , Lesca M. Holdt
    •  & Kathryn J. Moore
  • Nat. Metab. | Article |

    Impaired adipocyte insulin signalling characterizes insulin resistance. Here the authors show that the hormone-sensitive lipase can sequester the glucose-responsive transcription factor ChREBP in the cytoplasm, which prevents transcription of its target ELOVL6, resulting in reduced insulin signalling.

    • Pauline Morigny
    • , Marianne Houssier
    • , Aline Mairal
    • , Claire Ghilain
    • , Etienne Mouisel
    • , Fadila Benhamed
    • , Bernard Masri
    • , Emeline Recazens
    • , Pierre-Damien Denechaud
    • , Geneviève Tavernier
    • , Sylvie Caspar-Bauguil
    • , Sam Virtue
    • , Veronika Sramkova
    • , Laurent Monbrun
    • , Anne Mazars
    • , Madjid Zanoun
    • , Sandra Guilmeau
    • , Valentin Barquissau
    • , Diane Beuzelin
    • , Sophie Bonnel
    • , Marie Marques
    • , Boris Monge-Roffarello
    • , Corinne Lefort
    • , Barbara Fielding
    • , Thierry Sulpice
    • , Arne Astrup
    • , Bernard Payrastre
    • , Justine Bertrand-Michel
    • , Emmanuelle Meugnier
    • , Laetitia Ligat
    • , Frédéric Lopez
    • , Hervé Guillou
    • , Charlotte Ling
    • , Cecilia Holm
    • , Remi Rabasa-Lhoret
    • , Wim H. M. Saris
    • , Vladimir Stich
    • , Peter Arner
    • , Mikael Rydén
    • , Cedric Moro
    • , Nathalie Viguerie
    • , Matthew Harms
    • , Stefan Hallén
    • , Antonio Vidal-Puig
    • , Hubert Vidal
    • , Catherine Postic
    •  & Dominique Langin
  • Nat. Metab. | Article |

    The metabolic dependencies of androgen receptor (AR)-driven growth in prostate adenocarcinoma are largely unknown but could represent a therapeutic target when hormonal manipulations fail. Here the authors demonstrate that the mitochondrial pyruvate carrier (MPC) is transcriptionally regulated by AR and that MPC inhibition suppresses tumour growth in hormone-responsive and castrate-resistant conditions.

    • David A. Bader
    • , Sean M. Hartig
    • , Vasanta Putluri
    • , Christopher Foley
    • , Mark P. Hamilton
    • , Eric A. Smith
    • , Pradip K. Saha
    • , Anil Panigrahi
    • , Christopher Walker
    • , Lin Zong
    • , Heidi Martini-Stoica
    • , Rui Chen
    • , Kimal Rajapakshe
    • , Cristian Coarfa
    • , Arun Sreekumar
    • , Nicholas Mitsiades
    • , James A. Bankson
    • , Michael M. Ittmann
    • , Bert W. O’Malley
    • , Nagireddy Putluri
    •  & Sean E. McGuire
  • Nat. Metab. | Article |

    Obese and dysfunctional adipose tissue is known to be hypoxic. Here the authors show that adipocyte oxygen consumption increases early after onset of high-fat diet feeding owing to activation of the mitochondrial protein ANT2 and that specific inhibition of ANT2 reduces adipose tissue hypoxia, inflammation and insulin resistance.

    • Jong Bae Seo
    • , Matthew Riopel
    • , Pedro Cabrales
    • , Jin Young Huh
    • , Gautam K. Bandyopadhyay
    • , Aleksander Yu Andreyev
    • , Anne N. Murphy
    • , Scott C. Beeman
    • , Gordon I. Smith
    • , Samuel Klein
    • , Yun Sok Lee
    •  & Jerrold M. Olefsky
  • Nat. Metab. | Article |

    Glucose-dependent insulinotropic polypeptide (GIP) is a gut incretin hormone released in response to nutrients. Here, the authors report an anti-inflammatory and antiobesogenic mechanism of GIP by showing that loss of GIP receptor signalling in myeloid cells promotes pro-inflammatory S100A8/A9 release in adipose tissue.

    • Fernanda Dana Mantelmacher
    • , Isabel Zvibel
    • , Keren Cohen
    • , Alona Epshtein
    • , Metsada Pasmanik-Chor
    • , Thomas Vogl
    • , Yael Kuperman
    • , Shai Weiss
    • , Daniel J. Drucker
    • , Chen Varol
    •  & Sigal Fishman