Alexandre Fisette

Functional identity of hypothalamic melanocortin neurons depends on Tbx3

Latest Research

  • Article |

    The conventional view holds that hypoxia confers drug resistance. In contrast, here the authors use a multilayer ‘omics data approach to characterize the molecular features associated with tumour hypoxia and identify molecular alterations that correlate with both drug-resistant and drug-sensitive responses to approved drugs.

    • Youqiong Ye
    • , Qingsong Hu
    • , Hu Chen
    • , Ke Liang
    • , Yuan Yuan
    • , Yu Xiang
    • , Hang Ruan
    • , Zhao Zhang
    • , Anren Song
    • , Huiwen Zhang
    • , Lingxiang Liu
    • , Lixia Diao
    • , Yanyan Lou
    • , Bingying Zhou
    • , Li Wang
    • , Shengtao Zhou
    • , Jianjun Gao
    • , Eric Jonasch
    • , Steven H. Lin
    • , Yang Xia
    • , Chunru Lin
    • , Liuqing Yang
    • , Gordon B. Mills
    • , Han Liang
    •  & Leng Han
  • Metabolic Messengers |

    Secreted from adipocytes, adiponectin exerts primarily anti-apoptotic, antiinflammatory, anti-fibrotic and insulin-sensitizing activities on multiple tissues. Here, Straub and Scherer provide a concise overview of the history of adiponectin, its physiological role and molecular mechanism of action.

    • Leon G. Straub
    •  & Philipp E. Scherer
  • Article |

    The oxidative pentose-phosphate pathway (oxPPP) is a major NADPH producer. Here the authors show that malic enzyme or isocitrate dehydrogenase can support the growth of cells lacking the oxPPP, but the oxPPP is necessary to maintain a normal NADPH/NADP ratio, DHFR activity and folate metabolism.

    • Li Chen
    • , Zhaoyue Zhang
    • , Atsushi Hoshino
    • , Henry D. Zheng
    • , Michael Morley
    • , Zoltan Arany
    •  & Joshua D. Rabinowitz
  • Article |

    Amino acids are required for cell survival and growth. However, the different requirements of amino acid metabolic pathways in normal haematopoiesis and leukaemogenesis have not been explored. Here the authors focus on the transporter of neutral amino acids and show that malignant blood cells rely more on ASCT2-mediated amino acid metabolism than normal cells.

    • Fang Ni
    • , Wen-Mei Yu
    • , Zhiguo Li
    • , Douglas K. Graham
    • , Lingtao Jin
    • , Sumin Kang
    • , Michael R. Rossi
    • , Shiyong Li
    • , Hal E. Broxmeyer
    •  & Cheng-Kui Qu
  • Review Article |

    The protein kinase complex mechanistic target of rapamycin complex 1 (mTORC1) is a key cellular nutrient and energy sensor that integrates several inputs to regulate cell growth. Here, the authors discuss the molecular logic of the mTORC1 signalling network and its importance in coupling growth signals to the control of cellular metabolism.

    • Alexander J. Valvezan
    •  & Brendan D. Manning
  • Perspective |

    Activation of tissue-resident myeloid cells in the brain, known as microglia, is thought to drive obesity-associated hypothalamic dysfunction. The authors of this Perspective present a more nuanced view of microglia, echoing lessons learned from the field of adipose macrophage biology: instead of simply responding to diet-induced damage, microglia are proposed to act as nutrient and environmental sensors that regulate hypothalamic physiology, a role that, if hijacked by chronic overnutrition, can produce disease.

    • Martin Valdearcos
    • , Martin G. Myers Jr
    •  & Suneil K. Koliwad

News & Comment

  • Editorial |

    This month, we introduce a new series of articles, called Metabolic Messengers, dedicated to molecules involved in cellular communication and inter-tissue cross-talk.

  • News & Views |

    As one of the most highly consumed amino acids in cultured cancer cells, glutamine is an attractive target for anti-cancer therapy, and glutaminase inhibitors are currently in clinical trials. In this issue, Ni et al. show that blocking this pathway by targeting the glutamine importer ASCT2 (SLC1A5) decreases tumorigenesis in mouse leukaemia models while largely sparing normal haematopoiesis.

    • Richard Possemato
  • News & Views |

    Patients with severe diabetes rely on insulin injections to control their blood glucose. A study now provides evidence that human cells that normally do not release insulin can be converted into insulin-producing cells that are able to normalize glycaemia in diabetic mice.

    • Mostafa Bakhti
    •  & Heiko Lickert
  • News & Views |

    The senescence-associated secretory phenotype (SASP) is responsible for the deleterious effects of senescent cells in ageing and cancer. A new study shows that NAD+ metabolism can regulate the pro-inflammatory SASP, thereby promoting tumorigenesis.

    • Pia Pernille Søgaard
    •  & Jesús Gil
  • News & Views |

    Hypothalamic neuronal diversity is at the core of whole-body energy-homeostasis control, but the molecular mechanisms governing neuronal neuropeptide specification remain incompletely understood. A new study in Nature Metabolism adds a relevant piece to the puzzle of how key hypothalamic neuronal populations maintain their peptidergic identity throughout the lifespan.

    • Arnaud Obri
    •  & Marc Claret