Ricardo Gutierrez-Garcia

Prostaglandin signals from adult germline stem cells delay somatic ageing of Caenorhabditis elegans

Latest Research

  • Article |

    Some follicular B cell lymphomas harbour activating mutations in RRAGC, activator of the nutrient sensor mTORC1. Here the authors show that these mutations confer insensitivity to nutrient deprivation and synergize with paracrine cues from the supportive T cell microenvironment to accelerate lymphomagenesis, but impose vulnerability to inhibition of mTORC1.

    • Ana Ortega-Molina
    • , Nerea Deleyto-Seldas
    • , Joaquim Carreras
    • , Alba Sanz
    • , Cristina Lebrero-Fernández
    • , Camino Menéndez
    • , Andrew Vandenberg
    • , Beatriz Fernández-Ruiz
    • , Leyre Marín-Arraiza
    • , Celia de la Calle Arregui
    • , Ana Belén Plata-Gómez
    • , Eduardo Caleiras
    • , Alba de Martino
    • , Nuria Martínez-Martín
    • , Kevin Troulé
    • , Elena Piñeiro-Yáñez
    • , Naoya Nakamura
    • , Shamzah Araf
    • , Gabriel D. Victora
    • , Jessica Okosun
    • , Jude Fitzgibbon
    •  & Alejo Efeyan
  • Article |

    Folgueira et al. show that dopamine signalling in the lateral hypothalamic area and the zona incerta reduces body weight and increases energy expenditure by increasing brown adipose tissue thermogenesis in rodents. Weight loss and increased energy expenditure were also observed in patients treated with a dopamine receptor 2 agonist.

    • Cintia Folgueira
    • , Daniel Beiroa
    • , Begoña Porteiro
    • , Manon Duquenne
    • , Emma Puighermanal
    • , Marcos F. Fondevila
    • , Silvia Barja-Fernández
    • , Rosalia Gallego
    • , René Hernández-Bautista
    • , Cecilia Castelao
    • , Ana Senra
    • , Patricia Seoane-Collazo
    • , Noemi Gómez-Lado
    • , Pablo Aguiar
    • , Diana Guallar
    • , Miguel Fidalgo
    • , Amparo Romero-Pico
    • , Roger Adan
    • , Clemence Blouet
    • , Jose Luís Labandeira-García
    • , Françoise Jeanrenaud
    • , Imre Kallo
    • , Zsolt Liposits
    • , Javier Salvador
    • , Vincent Prevot
    • , Carlos Dieguez
    • , Miguel López
    • , Emmanuel Valjent
    • , Gema Frühbeck
    • , Luisa M. Seoane
    •  & Ruben Nogueiras
  • Article |

    Brown adipose tissue (BAT) has high thermogenic potential and is considered a promising target to counteract obesity. Here de Jong et al. demonstrate that human BAT is more similar to classical brown than to beige adipose tissue from mice kept at thermoneutrality and challenged with a high-fat diet.

    • Jasper M. A. de Jong
    • , Wenfei Sun
    • , Nuno D. Pires
    • , Andrea Frontini
    • , Miroslav Balaz
    • , Naja Z. Jespersen
    • , Amir Feizi
    • , Katarina Petrovic
    • , Alexander W. Fischer
    • , Muhammad Hamza Bokhari
    • , Tarja Niemi
    • , Pirjo Nuutila
    • , Saverio Cinti
    • , Søren Nielsen
    • , Camilla Scheele
    • , Kirsi Virtanen
    • , Barbara Cannon
    • , Jan Nedergaard
    • , Christian Wolfrum
    •  & Natasa Petrovic
  • Article |

    Although germline removal normally extends Caenorhabditis elegans lifespan, Lee et al. show that low temperature does not extend lifespan in germline-lacking mutant worms. Cold temperatures (10 °C, 15 °C) delay germline stem cell exhaustion, releasing prostaglandin E2 hormone, which induces cbs-1 in the intestine to produce hydrogen sulfide and prolong lifespan.

    • Hyun Ju Lee
    • , Alireza Noormohammadi
    • , Seda Koyuncu
    • , Giuseppe Calculli
    • , Milos S. Simic
    • , Marija Herholz
    • , Aleksandra Trifunovic
    •  & David Vilchez
  • Review Article |

    Jeffrey Friedman reviews the biology and evolutionary role of leptin as a regulator of behaviour and metabolism. He goes on to propose the existence of two states of obesity, distinguished by hyposecretion or hypersecretion of leptin, referred to as ‘Type 1 obesity’ and ‘Type 2 obesity’, respectively.

    • Jeffrey M. Friedman
  • Letter |

    m6A mRNA methylation regulates several cellular processes, including cancer progression and stem cell maintenance. Here, De Jesus and colleagues demonstrate that the m6A landscape segregates human type 2 diabetic islets from controls and that m6A is fundamental for human β-cell biology.

    • Dario F. De Jesus
    • , Zijie Zhang
    • , Sevim Kahraman
    • , Natalie K. Brown
    • , Mengjie Chen
    • , Jiang Hu
    • , Manoj K. Gupta
    • , Chuan He
    •  & Rohit N. Kulkarni

News & Comment

  • News & Views |

    The gene encoding the RagC GTPase (RRAGC), an activator of a nutrient-sensing pathway that drives cellular anabolism, is mutated in 15% of follicular lymphoma cases. A new study provides evidence that RRAGC mutations promote lymphomagenesis by distorting the nutrient-dependent control of paracrine signals from the microenvironment, thus enhancing B-cell activation.

    • Ulf Klein
  • Comment |

    Mammalian cell culture represents a cornerstone of modern biomedical research. There is growing appreciation that the media conditions in which cells are cultured can profoundly influence the observed biology and reproducibility. Here, we consider a key but often ignored variable, oxygen, and review why being mindful of this environmental parameter is so important in the design and interpretation of cell culture studies.

    • Tslil Ast
    •  & Vamsi K. Mootha
  • Comment |

    Modern mass spectrometric technologies provide quantitative readouts for a wide variety of lipid specimens. However, many studies do not report absolute lipid concentrations and differ vastly in methodologies, workflows and data presentation. Therefore, we encourage researchers to engage with the Lipidomics Standards Initiative to develop common standards for minimum acceptable data quality and reporting for lipidomics data, to take lipidomics research to the next level.

    • Gerhard Liebisch
    • , Robert Ahrends
    • , Makoto Arita
    • , Masanori Arita
    • , John A. Bowden
    • , Christer S. Ejsing
    • , William J. Griffiths
    • , Michal Holčapek
    • , Harald Köfeler
    • , Todd W. Mitchell
    • , Markus R. Wenk
    •  & Kim Ekroos
  • News & Views |

    Diabetes mellitus invariably involves impaired regulation of insulin secretion from pancreatic β cells, as a result of unfavourable environmental influences in combination with aberrant expression of risk genes at either the transcriptional or the translational level. A recent report in Nature Metabolism explores a novel role of mRNA methylation in β-cell function and suggests that its downregulation causes type 2 diabetes.

    • Erik Renström
    •  & Enming Zhang