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AI support for T1D therapy

Latest Research

  • Article |

    Cancer cells have heightened demands for non-essential amino acids to support proliferation and redox homeostasis. Here, Zhang et al. propose the intersection of cysteine metabolism and polyamine synthesis as an unexplored metabolic vulnerability of cancer cells.

    • Tong Zhang
    • , Christin Bauer
    • , Alice C. Newman
    • , Alejandro Huerta Uribe
    • , Dimitris Athineos
    • , Karen Blyth
    •  & Oliver D. K. Maddocks
  • Review Article |

    Cellular metabolic demand skyrockets during intense exercise, thus rendering the communication of metabolic state essential for organismal homeostasis. Murphy, Watt and Febbraio discuss the physiological processes governing intertissue communication during exercise and the molecules mediating such cross-talk.

    • Robyn M. Murphy
    • , Matthew J. Watt
    •  & Mark A. Febbraio
  • Review Article |

    Hargreaves and Spriet review regulatory mechanisms of ATP resynthesis during exercise and summarize nutritional interventions that target muscle metabolism to enhance athletic performance.

    • Mark Hargreaves
    •  & Lawrence L. Spriet
  • Article |

    Transient glucose restriction after the activation of CD8+ TE cells ex vivo induces metabolic remodelling that enhances effector functions and tumour clearance in mice.

    • Ramon I. Klein Geltink
    • , Joy Edwards-Hicks
    • , Petya Apostolova
    • , David O’Sullivan
    • , David E. Sanin
    • , Annette E. Patterson
    • , Daniel J. Puleston
    • , Nina A. M. Ligthart
    • , Joerg M. Buescher
    • , Katarzyna M. Grzes
    • , Agnieszka M. Kabat
    • , Michal Stanczak
    • , Jonathan D. Curtis
    • , Fabian Hässler
    • , Franziska M. Uhl
    • , Mario Fabri
    • , Robert Zeiser
    • , Edward J. Pearce
    •  & Erika L. Pearce
  • Letter |

    Steinberg and colleagues show that long-chain fatty acyl-CoA esters are endogenous ligands for the drug-binding domain of AMPK β1–containing isoforms, and that such binding is critical for enhancement of fatty acid oxidation. These data may help explain how AMPK integrates responses to ketogenic diets, fasting or endurance exercise across distinct tissues in the absence of changes in adenine nucleotides.

    • Stephen L. Pinkosky
    • , John W. Scott
    • , Eric M. Desjardins
    • , Brennan K. Smith
    • , Emily A. Day
    • , Rebecca J. Ford
    • , Christopher G. Langendorf
    • , Naomi X. Y. Ling
    • , Tracy L. Nero
    • , Kim Loh
    • , Sandra Galic
    • , Ashfaqul Hoque
    • , William J. Smiles
    • , Kevin R. W. Ngoei
    • , Michael W. Parker
    • , Yan Yan
    • , Karsten Melcher
    • , Bruce E. Kemp
    • , Jonathan S. Oakhill
    •  & Gregory R. Steinberg
  • Article |

    Zhu and colleagues show that chronic activation of arcuate nucleus GABA+ neurons, agouti-related protein (AgRP) neurons alone or non-AgRP GABA+ neurons promotes severe obesity, but only inhibition of all GABA+ neurons can reverse the obese phenotype of hyperphagic mice, thus suggesting a redundant role for arcuate GABA+ neurons in obesity.

    • Canjun Zhu
    • , Zhiying Jiang
    • , Yuanzhong Xu
    • , Zhao-Lin Cai
    • , Qingyan Jiang
    • , Yong Xu
    • , Mingshan Xue
    • , Benjamin R. Arenkiel
    • , Qi Wu
    • , Gang Shu
    •  & Qingchun Tong

News & Comment

  • News & Views |

    Cancer cells require exogenous cysteine for proliferation and survival. In this issue of Nature Metabolism, Zhang et al. demonstrate that deletion of 5-methylthioadenosine phosphorylase promotes the synthesis of polyamines from methionine, thereby conferring sensitivity to cysteine starvation.

    • Joseph A. Combs
    •  & Gina M. DeNicola
  • News & Views |

    The mechanistic target of rapamycin complex 1 (mTORC1) network integrates nutrient and energy signals that regulate metabolism and cell growth. Orozco et al. now show that the glycolytic intermediate dihydroxyacetone phosphate (DHAP) relays glycolytic activity to mTORC1 signalling.

    • Gerta Hoxhaj
    • , Jason W. Locasale
    •  & Issam Ben-Sahra
  • News & Views |

    GABA-expressing neurons in the arcuate nucleus of the hypothalamus regulate obesity in mice. A recent study indicates the importance of unexamined cell types.

    • Scott M. Sternson
  • News & Views |

    AMPK is a crucial sensor of the cellular energetic state and is also activated during glucose starvation. A new study reports that AMP-activated protein kinase (AMPK) is activated by interaction with long-chain fatty acyl–CoA esters, which appear to be the long-sought endogenous AMPK ligands that bind the allosteric drug and metabolite (ADaM) site.

    • D. Grahame Hardie
  • News & Views |

    Diet and exercise are the two pillars of a healthful lifestyle for stemming the rising tide of metabolic disease. A new study in this issue reveals that the health benefits of diet and aerobic exercise are more interdependent than previously appreciated, thus reinforcing the importance of a holistic approach to maintaining a healthful lifestyle.

    • Katja A. Lamia
  • News & Views |

    Caffa et al. report in Nature that hormone-receptor-positive breast cancer is sensitive to a form of ‘dietary augmentation therapy’ that implements periods of fasting, thus enhancing anti-cancer therapy.

    • Marcus D. Goncalves
    •  & Lewis C. Cantley