Carlos Carmona-Fontaine

Glutamine withdrawal selects pluripotent stem cells

Latest Research

  • Letter |

    Caused by a compromised lymphatic system, lymphoedema leads to fluid retention and tissue swelling, and is treated primarily with physical therapy. Here the authors present a metabolic approach to reduce lymphoedema by providing the ketone body β-hydroxybutyrate or by feeding ketogenic diet, which increases lymphangiogenesis and reduces fluid retention in mice.

    • Melissa García-Caballero
    • , Annalisa Zecchin
    • , Joris Souffreau
    • , Anh-Co Khanh Truong
    • , Laure-Anne Teuwen
    • , Wesley Vermaelen
    • , Rosa Martín-Pérez
    • , Pauline de Zeeuw
    • , Ann Bouché
    • , Stefan Vinckier
    • , Ivo Cornelissen
    • , Guy Eelen
    • , Bart Ghesquière
    • , Massimiliano Mazzone
    • , Mieke Dewerchin
    •  & Peter Carmeliet
  • Article |

    Macrophages engage in a sequence of dynamic functional changes during immune responses. Here the authors elucidate a two-stage remodelling of the tricarboxylic acid cycle during this process, which is driven by regulation of the pyruvate dehydrogenase and the oxoglutarate dehydrogenase complexes, and causes transient accumulation of immunoregulatory metabolites.

    • Gretchen L. Seim
    • , Emily C. Britt
    • , Steven V. John
    • , Franklin J. Yeo
    • , Aaron R. Johnson
    • , Richard S. Eisenstein
    • , David J. Pagliarini
    •  & Jing Fan
  • Article |

    Spontaneous control of HIV is linked to the ability of CD8+ T cells to eliminate infected CD4+ T cells. Here, the authors uncover metabolic differences between HIV-specific, central memory CD8+ T cells from spontaneous HIV controllers and antiretrovirally treated non-controllers, and show that in vitro metabolic reprogramming enhances the antiviral response in non-controllers cells.

    • Mathieu Angin
    • , Stevenn Volant
    • , Caroline Passaes
    • , Camille Lecuroux
    • , Valérie Monceaux
    • , Marie-Agnès Dillies
    • , José Carlos Valle-Casuso
    • , Gianfranco Pancino
    • , Bruno Vaslin
    • , Roger Le Grand
    • , Laurence Weiss
    • , Cecile Goujard
    • , Laurence Meyer
    • , Faroudy Boufassa
    • , Michaela Müller-Trutwin
    • , Olivier Lambotte
    •  & Asier Sáez-Cirión
  • Article |

    Increased metabolic activity promotes HIV-1 infection in CD4 T lymphocytes, but the contribution of different metabolic pathways is unclear. Here the authors show that carbon entry into the citric acid cycle is required to support the early stages of HIV-1 infection.

    • Isabelle Clerc
    • , Daouda Abba Moussa
    • , Zoi Vahlas
    • , Saverio Tardito
    • , Leal Oburoglu
    • , Thomas J. Hope
    • , Marc Sitbon
    • , Valérie Dardalhon
    • , Cédric Mongellaz
    •  & Naomi Taylor

News & Comment

  • News & Views |

    Lymphedema, a condition of fluid retention and tissue swelling, is currently incurable and is treated primarily with physical therapy. Studies in mice reveal that intake of a ketogenic diet or exogenous ketone bodies may alleviate lymphedema by increasing the formation of lymphatic vessels, which can drain excess lymph fluid.

    • Patrycja Puchalska
    •  & Peter A. Crawford
  • News & Views |

    The loss of T cell immune function as a result of human immunodeficiency virus (HIV) infection leads to opportunistic infections and certain HIV-associated cancers. Two recent studies shed light on the complex immunometabolic changes during HIV infection and open the door to metabolic treatment options that could ultimately cure HIV.

    • Ramon I. Klein Geltink
  • Editorial |

    Awareness of non-alcoholic steatohepatitis (NASH) and its symptoms is essential for early detection, and an informed public is also more likely to take action against NASH development.

  • News & Views |

    The entry of remnants of cholesterol-rich lipoproteins, such as low-density lipoprotein (LDL), from the blood stream into the intima of large arteries initiates and then perpetuates atherosclerosis. A study published in Nature sheds new light on this important process by identifying scavenger receptor BI (SR-BI) as a major receptor that mediates LDL delivery across the endothelium into arteries.

    • Xinbo Zhang
    •  & Carlos Fernández-Hernando
  • News & Views |

    Living organisms face the dual challenge of acquiring enough iron to perform biological functions while preventing toxic iron accretion. A study now shows that sensing of iron-catalysed free radicals by a druggable gene-regulatory pathway helps the body avoid iron poisoning.

    • Sandro Altamura
    •  & Bruno Galy