David Unnersjoe-Jess. Cover Design: Thomas Phillips

The biophysical basis of kidney ultrafiltration

Latest Research

  • Letter |

    Itaconate production is a hallmark of inflammatory activated macrophages. Swain et al. compare the biological effects of itaconate and its common derivatives, identifying a new regulatory mode of inhibiting IL-1β secretion and enhancing IFN-β signalling.

    • Amanda Swain
    • , Monika Bambouskova
    • , Hyeryun Kim
    • , Prabhakar Sairam Andhey
    • , Dustin Duncan
    • , Karine Auclair
    • , Victor Chubukov
    • , Donald M. Simons
    • , Thomas P. Roddy
    • , Kelly M. Stewart
    •  & Maxim N. Artyomov
  • Article |

    Thermogenic adipose tissue has been suggested as a potential target to treat metabolic diseases. Here, Tran et al. show that a long noncoding RNA, LINC00473, is induced during activation of thermogenic adipocytes and regulates energy metabolism through interorganelle communication.

    • Khanh-Van Tran
    • , Erin L. Brown
    • , Tiffany DeSouza
    • , Naja Zenius Jespersen
    • , Cecilie Nandrup-Bus
    • , Qin Yang
    • , Zinger Yang
    • , Anand Desai
    • , So Yun Min
    • , Raziel Rojas-Rodriguez
    • , Morten Lundh
    • , Amir Feizi
    • , Hanni Willenbrock
    • , Therese Juhlin Larsen
    • , Mai Charlotte Krogh Severinsen
    • , Kimberly Malka
    • , Anthony M. Mozzicato
    • , Atul S. Deshmukh
    • , Brice Emanuelli
    • , Bente Klarlund Pedersen
    • , Timothy Fitzgibbons
    • , Camilla Scheele
    • , Silvia Corvera
    •  & Søren Nielsen
  • Article |

    Currently, there is no approved treatment for NAFLD and NASH. Here, Boland et al. show that the GLP-1R and GCGR dual-agonist cotadutide reduces hepatic steatosis, inflammation and fibrosis via GCGR agonism, and glucose homeostasis and weight gain by activating GLP-1 signalling.

    • Michelle L. Boland
    • , Rhianna C. Laker
    • , Karly Mather
    • , Arkadiusz Nawrocki
    • , Stephanie Oldham
    • , Brandon B. Boland
    • , Hilary Lewis
    • , James Conway
    • , Jacqueline Naylor
    • , Silvia Guionaud
    • , Michael Feigh
    • , Sanne S. Veidal
    • , Louise Lantier
    • , Owen P. McGuinness
    • , Joseph Grimsby
    • , Cristina M. Rondinone
    • , Lutz Jermutus
    • , Martin R. Larsen
    • , James L. Trevaskis
    •  & Christopher J. Rhodes
  • Letter |

    Tharyan et al. identify NFYB-1 as a regulator of mitochondrial function that represses lysosomal prosaposin. The NFYB-1–prosaposin signalling axis coordinates lysosomal-to-mitochondria signalling via cardiolipin to enhance cellular mitochondrial function and longevity in C. elegans.

    • Rebecca George Tharyan
    • , Andrea Annibal
    • , Isabelle Schiffer
    • , Raymond Laboy
    • , Ilian Atanassov
    • , Anna Luise Weber
    • , Birgit Gerisch
    •  & Adam Antebi
  • Article |

    Morphological changes in kidney glomerular ultrastructure and altered compression of the glomerular basement membrane are shown to correlate with albuminuria.

    • Linus Butt
    • , David Unnersjö-Jess
    • , Martin Höhne
    • , Aurelie Edwards
    • , Julia Binz-Lotter
    • , Dervla Reilly
    • , Robert Hahnfeldt
    • , Vera Ziegler
    • , Katharina Fremter
    • , Markus M. Rinschen
    • , Martin Helmstädter
    • , Lena K. Ebert
    • , Hayo Castrop
    • , Matthias J. Hackl
    • , Gerd Walz
    • , Paul T. Brinkkoetter
    • , Max C. Liebau
    • , Kálmán Tory
    • , Peter F. Hoyer
    • , Bodo B. Beck
    • , Hjalmar Brismar
    • , Hans Blom
    • , Bernhard Schermer
    •  & Thomas Benzing
  • Article |

    β-cell dysfunction in diabetes is caused by glucose and inflammation toxicity. Here, Fu et al. show that β-cell glucose metabolism can be protective though pyruvate carboxylase–mediated shunting of arginine to ureagenesis and away from toxic nitric oxide production, thus suppressing inflammation.

    • Accalia Fu
    • , Juan Carlos Alvarez-Perez
    • , Daina Avizonis
    • , Tatsuya Kin
    • , Scott B. Ficarro
    • , Dong Wook Choi
    • , Esra Karakose
    • , Mehmet G. Badur
    • , Lindsay Evans
    • , Carolina Rosselot
    • , Gaelle Bridon
    • , Gregory H. Bird
    • , Hyuk-Soo Seo
    • , Sirano Dhe-Paganon
    • , Jurre J. Kamphorst
    • , Andrew F. Stewart
    • , A. M. James Shapiro
    • , Jarrod A. Marto
    • , Loren D. Walensky
    • , Russell G. Jones
    • , Adolfo Garcia-Ocana
    •  & Nika N. Danial

News & Comment

  • News & Views |

    Thermogenic adipocytes can burn lipids and carbohydrates for heat generation. The finding that a primate-specific long non-coding RNA regulates lipolysis and respiration in thermogenic adipocytes reveals a new mechanism controlling thermogenic adipocyte metabolism in humans.

    • Dan Xu
    •  & Lei Sun
  • Comment |

    As the metabolism community has grown and diversified with scientists from multidisciplinary backgrounds, metabolic terminology has evolved and expanded. In this Comment, we reflect on this new vernacular and how established terminology can guide future discussions of metabolic research.

    • Mary-Ellen Harper
    •  & Mary-Elizabeth Patti
  • News & Views |

    Exposure to high glucose under inflammatory conditions is detrimental to insulin-secreting beta cells in the pancreas. Fu and colleagues describe a metabolic axis that decreases production of the ‘danger molecule’ nitric oxide and improves the survival of beta cells exposed to an inflammatory milieu, thus paving the way to new interventions for diabetes.

    • Christian Frezza
  • News & Views |

    Maintaining cellular NAD levels through supplementation with intermediates of NAD synthesis has considerable health benefits. A new study demonstrates that the reduced form of nicotinamide riboside, NRH, can be converted to NAD in a biosynthetic pathway that involves adenosine kinase, thus strongly boosting NAD levels in cells and tissues.

    • Mathias Ziegler
    •  & Andrey A. Nikiforov
  • News & Views |

    Fructose, a monosaccharide derived from fruits, is primarily consumed in a form combined with glucose as sugar or as a component of high-fructose corn syrup added as a sweetener to processed foods and carbonated beverages. Increased consumption of fructose has emerged as a major contributor to non-alcoholic fatty liver disease, dyslipidaemia, insulin resistance and diabetes. Now Zhao et al. show that hepatic lipid synthesis is increased by fructose metabolism in both the liver and intestine.

    • Catherine Postic
  • News & Views |

    Macrophages are required for postinjury skeletal muscle regeneration. A new study reveals that proinflammatory macrophages produce meteorin-like, which promotes muscle stem cell expansion through the Stat3–IGF1 axis and then shifts their inflammatory profile to allow return to homeostasis.

    • Bénédicte Chazaud