liver cells

Asters maintain cholesterol homeostasis

  • Xu Xiao
  • John Paul Kennelly
  • Peter Tontonoz


  • Person surrounded by brain cells and neurocircuits

    This Focus brings together a selection of Reviews, Perspectives and related research that integrate the most recent advances in our understanding of how the brain controls energy homeostasis. This is presented both from a neurocircuit perspective describing the initiation or cessation of eating, as well as from a more detailed view of how these processes occur at the cellular level.

  • Crossing arrows

    The Career Pathways series features the stories of Nature Metabolism authors and their self-professed journeys to publication as young investigators. This Collection brings together the Career Pathway pieces and the original research published in Nature Metabolism by the authors.

  • science lab

    This Collection highlights best practices in experimental design, analysis, and reporting to support the metabolic research community and increase reproducibility of research in the life sciences

  • a fly, a worm, and a fish

    This growing web collection features research articles published in Nature Metabolism that make use of non-mammalian model organisms. With this collection we aim to highlight the usefulness of these models for unraveling new metabolic biology.

Nature Metabolism is a Transformative Journal; authors can publish using the traditional publishing route OR via immediate gold Open Access.

Our Open Access option complies with funder and institutional requirements.


    • We show that the retinal pigment epithelium (RPE) — the outermost layer of the retina — is a local source of insulin that is modulated by starvation and phagocytosis, separate from pancreatic insulin. Further, this RPE-derived insulin has functional relevance in retinal physiology, retinal metabolic homeostasis and in limiting retinal disease.

      Research Briefing
    • Dai and colleagues show that activation of AMPK by glucose starvation leads to phosphorylation of GATOR2 and affects nutrient-dependent activation of mTORC1.

      • Nerea Deleyto-Seldas
      • Alejo Efeyan
      News & Views
    • Lactate build up in the tumour microenvironments is thought to dampen anti-tumour immunity, but in vitro pre-conditioning T cells with lactate enhances anti-tumour activity in vivo in pre-clinical mouse models.

      • Ju Hee Oh
      • Anne-Sophie Archambault
      • Ramon I. Klein Geltink
      News & Views
    • Some individuals with obesity have a healthy metabolic profile and are not at increased risk for diabetes or cardiovascular disease. The mechanisms behind this phenomenon are poorly understood, but recent work now characterizes the biological underpinnings of the metabolically healthy obese phenotype.

      • Mathias Rask-Andersen
      • Åsa Johansson
      News & Views
    • Investigation of multi-omic changes and their effects on regulation of metabolic pathways confirm anaplerotic deficiencies in methylmalonic acidaemia, strengthening the need for future therapies aimed at replenishing intermediates of the tricarboxylic acid cycle.

      • PamelaSara E. Head
      • Charles P. Venditti
      News & Views