T cells

Microenvironment pH shapes T-cell fate

  • Hongcheng Cheng
  • Yajing Qiu
  • Guideng Li


  • Person surrounded by brain cells and neurocircuits

    This Focus brings together a selection of Reviews, Perspectives and related research that integrate the most recent advances in our understanding of how the brain controls energy homeostasis. This is presented both from a neurocircuit perspective describing the initiation or cessation of eating, as well as from a more detailed view of how these processes occur at the cellular level.

  • Crossing arrows

    The Career Pathways series features the stories of Nature Metabolism authors and their self-professed journeys to publication as young investigators. This Collection brings together the Career Pathway pieces and the original research published in Nature Metabolism by the authors.

  • science lab

    This Collection highlights best practices in experimental design, analysis, and reporting to support the metabolic research community and increase reproducibility of research in the life sciences

  • a fly, a worm, and a fish

    This growing web collection features research articles published in Nature Metabolism that make use of non-mammalian model organisms. With this collection we aim to highlight the usefulness of these models for unraveling new metabolic biology.

Nature Metabolism is a Transformative Journal; authors can publish using the traditional publishing route OR via immediate gold Open Access.

Our Open Access option complies with funder and institutional requirements.


    • Although astrocytes are largely glycolytic, they catabolize a variety of substrates via oxidative phosphorylation in the mitochondria. In this issue, Mi et al. show that oxidative phosphorylation in astrocytes protects the brain from inflammation and degeneration by degrading excess fatty acids.

      • Luis F. Rubio-Atonal
      • Maria S. Ioannou
      News & Views
    • Matsumura, Wei and Sakai discuss epitranscriptomic modifications and their links to metabolic disease, how genetic and environmental factors influence epitranscriptomics, and how the epitranscriptome is linked to the epigenome.

      • Yoshihiro Matsumura
      • Fan-Yan Wei
      • Juro Sakai
      Review Article
    • PCYT2 is an enzyme involved in lipid biosynthesis, and its genetic deficiency in zebrafish, mice and humans causes progressive muscle weakness. Importantly, PCYT2 activity declines in ageing muscles of mice and humans, and PCYT2 gene therapy in aged mice improves muscle strength, suggesting new therapeutic avenues to explore for maintaining muscle health in ageing.

      Research Briefing
    • Animals need to be able to evaluate environmental pH. Mechanisms that mediate sour taste and acid sensing have been reported across species, but less is known about the detection of high pH. Mi et al. identify the gene alkaliphile, which encodes a high-pH-gated chloride channel in the gustatory system of flies.

      • Scarlet J. Park
      • William W. Ja
      News & Views
    • Defective nicotinamide adenine dinucleotide (NAD+) metabolism is involved in various diseases. A study in Nature Metabolism identifies the cytosolic mitochondrial-RNA sensing system as a mediator that links NAD+ deficiency to kidney disease in humans and mice.

      • Hiroshi Itoh
      • Jun Yoshino
      News & Views