Spatial metabolomics meets isotopic metabolic tracing

Spatial metabolomics meets isotopic metabolic tracing

  • Gangqi Wang
  • Bram Heijs
  • Ton J. Rabelink


  • Person surrounded by brain cells and neurocircuits

    This Focus brings together a selection of Reviews, Perspectives and related research that integrate the most recent advances in our understanding of how the brain controls energy homeostasis. This is presented both from a neurocircuit perspective describing the initiation or cessation of eating, as well as from a more detailed view of how these processes occur at the cellular level.

  • Crossing arrows

    The Career Pathways series features the stories of Nature Metabolism authors and their self-professed journeys to publication as young investigators. This Collection brings together the Career Pathway pieces and the original research published in Nature Metabolism by the authors.

  • Metabolic networks

    Together with Nature Cell Biology and Nature Reviews Molecular Cell Biology, Nature Metabolism is excited to present a virtual conference in November 2022, focusing on coordination of metabolic processes across organelles, cells, tissues, and organs.

  • science lab

    This Collection highlights best practices in experimental design, analysis, and reporting to support the metabolic research community and increase reproducibility of research in the life sciences

Nature Metabolism is a Transformative Journal; authors can publish using the traditional publishing route OR via immediate gold Open Access.

Our Open Access option complies with funder and institutional requirements.


    • Microglia require a large amount of energy to clear plaques in the brains of people with Alzheimer’s disease. Leng et al. found that increased activity of the glycolytic enzyme hexokinase 2 (HK2) blocks microglial phagocytosis in Alzheimer’s disease. Inhibition of HK2 results in increased microglial energy production by a compensatory lipid metabolism response, restores phagocytosis and improves cognitive function.

      • Hayoung Choi
      • Inhee Mook-Jung
      News & Views
    • Hepatocellular carcinoma (HCC) is the 4th leading cause of cancer mortality. Modulation of tumour metabolism may represent a novel therapeutic strategy. Hexokinase 1, secreted into extracellular vesicles by activated hepatic stellate cells, is shown to be taken up by tumour cells, where it accelerates glycolysis and HCC growth.

      • Aveline Filliol
      • Robert F. Schwabe
      News & Views
    • SARS-CoV-2-induced anorexia triggers systemic metabolic alterations. In a study published in Nature, Karagiannis et al. show that the ketone body β-hydroxybutyrate (BHB) improves COVID-19 disease outcomes. Further, BHB metabolically and functionally reprograms CD4+ T cells, highlighting immunometabolic tuning of immunity in COVID-19.

      • Yan Wang
      • Hongbo Chi
      News & Views
    • Decreased insulin action and insulin receptor signalling contribute to the pathology of diabetes. Liu et al. uncover a role for the Ephrin type-B receptor 4 in insulin receptor degradation regulating liver and systemic insulin sensitivity.

      • Prisca Chapouton
      • Heiko Lickert
      News & Views
    • This Review summarizes emerging concepts for diabetes therapy aimed at specifically altering β cell biology and function, such as β cell insulin signalling, proliferation, differentiation, apoptosis, as well as the selective killing of senescent β cells.

      • Chirag Jain
      • Ansarullah
      • Heiko Lickert
      Review Article
  • Nature Metabolism is launching an online collection with articles highlighting best practices in experimental design, analysis and reporting to support the metabolic research community and increase the reproducibility of research in the life sciences.

  • The rapid increase in lipidomic data has triggered a community-based movement to develop guidelines and minimum requirements for generating, reporting and publishing lipidomic data. The creation of a dynamic checklist summarizing key details of lipidomic analyses using a common language has the potential to harmonize the field by improving both traceability and reproducibility.

    • Jeffrey G. McDonald
    • Christer S. Ejsing
    • Kim Ekroos
  • A better understanding of how the brain controls whole-body energy use and storage, as well as eating behaviour, will pave the way for improving therapeutics to fight metabolic diseases. This Focus presents a collection of Reviews, Perspectives and research Articles that integrate the most recent evidence on how the brain controls key aspects of whole-body metabolism.

  • Nature Metabolism and the Nature journals are raising the standards for reporting on sex and gender in research. Starting this June, authors will be prompted to provide details on how sex and gender were considered in study design.

  • Glucose clamps are challenging to conduct in mice and experimental approaches vary between laboratories, which complicates data interpretation and comparison of results. Here, we highlight key methodological differences and propose reporting standards for glucose clamps.

    • Julio E. Ayala
    • Louise Lantier
    • David H. Wasserman
  • Global scientific collaboration should endure despite the humanitarian crisis in Europe.