Volume 2 Issue 7, July 2024

Generative artificial intelligence (AI), exemplified by large language models such as ChatGPT, shows promise in mental health practice, aiding research, training and therapy. However, bias, inaccuracy and trust issues necessitate careful integration with human expertise.

Mood dysfunction is more common in people with brain tumors than in those with other tumor types, but the reasons for this association are unclear. Using various methods for lesion–symptom mapping, we identified brain locations in patients with diffuse glioma that are related to severe depressive symptoms or an absence of depressive symptoms.

This Review explores the link between mood disorders and circadian disruptions, including social jet lag and shift work, and offers new perspectives for therapeutic development in future chronobiology research.

This Review discusses the key factors that comprise the mental load of motherhood and the need to provide support for a healthy transition to motherhood.

Applying machine learning to an objective framework for suicidality, the authors demonstrate that four suicidal thought and behavior variables can be predicted with high accuracy and may present a scalable system for suicide risk assessment.

Altered patterns of effective connectivity in the brain’s default-mode network predicted both future dementia incidence and time to diagnosis.

In this Article, the authors present data showing that pregnant people seeking treatment for opioid use disorder who receive psychostimulant medication for attention deficit hyperactivity disorder were more likely to initiate and adhere to treatment with buprenorphine.

In this pilot study, the authors detected specific brain regions that can be precisely targeted with transcranial magnetic stimulation to influence heart rate. The heart–brain coupling might serve as a readout to identify optimal individualized transcranial magnetic stimulation targets for depression.

The authors present the secondary outcomes from a cluster-randomized controlled trial of the Health4Life multiple health behavior change intervention. The intervention showed short-term benefits for distress and depressive symptoms but was not more effective than an active control condition.

Using a large US cohort of adolescents, the authors examine exposomic and polygenic contributions to allostatic load and a mediating role of allostatic load on the path from exposomic and polygenic risks to psychopathology.

Authors present data supporting a neuropsychological pathway between emotion dysregulation and ADHD symptoms involving morphometry of the right pars orbitalis, transcriptomic, and white blood cell markers.

The authors report how the anatomical location of diffuse gliomas is related to the occurrence of severe depressive symptoms or the absence of depressive symptoms.

The authors synthesize data from previous literature on observational, experimental and medicinal cannabis research to assess rates and predictors of cannabis-associated psychotic symptoms.