Browse Articles

Using data from large longitudinal observational studies, the authors conducted a meta-analysis to investigate the association between loneliness and dementia.

In this pooled analysis, the authors evaluate the effects of psilocybin-assisted psychotherapy across various dimensions of psychiatric symptoms in people with cancer-related distress.

In this study, the authors use a transdiagnostic approach to assess functional connectivity in individuals with and without a psychiatric diagnosis, showing hypoconnectivity in the default mode, visual and limbic systems associated with suicidality.

In this Perspective, the authors review the literature regarding the differences between autobiographical and traumatic memory and introduce sensorimotor-based implications for understanding and treating post-traumatic stress disorder.

Integrative analyses that incorporate different levels of ‘-omics’ data represent a powerful tool for deciphering the biological mechanisms that underlie environmental influences on mental health and disease. This Comment highlights various aspects of such multi-omics approaches, using the example of the EU-funded environMENTAL project.

This Comment presents a high-level protocol for data harmonization within large cohorts, in which it postulates four main steps including (1) expert review, (2) pre-statistical harmonization, (3) statistical harmonization, and (4) validation.

The focus of much of contemporary research ethics is on compliance with established protocols. However, large data-driven neuroscience research raises new ethical concerns that have no agreed-upon solution. Here we reflect on these challenges and propose better integration of public and patient involvement in this evolving landscape.

This Comment explores new approaches to enrich large-scale population data, including incorporating macro-environmental and digital health measures.

To improve the reliability of research on the therapeutic benefits of psychedelics beyond placebo and expectation effects, the authors discuss the methodological considerations for selecting suitable control conditions in psychedelic trials and the neurobiology of placebo and expectation effects.

Using a large multisite dataset of people with major depressive disorder and healthy controls, the authors show global brain connectivity alterations in the sensorimotor, visual, and default mode networks.

Using multimodal brain imaging and organ-specific physiological markers from more than 18,000 adult participants of the UK Biobank database, this study reveals integrated pathways that explain the interplay between brain, body, environment and lifestyle, and their collective influence on mental health outcomes.

Analyses of functional MRI brain images of young people with depression revealed that altered brain connectivity associated with this disorder is circumscribed to specific networks and hub regions, including the default mode and attentional networks. The magnitude of these connectivity changes is a reliable predictor of depression symptom severity.

This mega-analysis of brain resting-state functional connectivity in young individuals with major depressive disorder scanned at six sites across four countries identified hub regions of the attentional and default mode networks as predictors of depression severity.

The authors present findings of more than 350 million primary-care visits over 14 years in the Norwegian healthcare system, indicating that 1 in 9 encounters involved a mental-health condition and peaking at age 40 years (18.7%).

Announced in this Comment and in collaboration with Nature Mental Health is the convening of the Earth Brain Health Commission, addressing innovative and multidisciplinary approaches to mitigating environment-related mental health harms and promoting wellbeing.

In a large dataset from the UK Biobank, the authors examine the relationships between regional gene expressions and structural and functional features of the cerebral cortex associated with risky behavior.

Translational science is often characterized metaphorically, as bridging the gaps among multidisciplinary research areas. However, in reality, translational work is often separate or excluded from clinical research. Integrating elements of translational and clinical work into more general mental health research is key to innovation and progress.

This study examining blood transcriptomic, neuroimaging and clinical data in people with schizophrenia shows a relationship between individual variations in gene transcription, brain structure and cognitive performance.

In this Perspective, authors overview the ‘social cure’ model employing group contexts, identity, and connections and argue for its use as a therapeutic framework for psychedelic treatment.