Zhao, Yang et al. used UK Biobank data to examine the role of lifestyle factors in depression. They conducted multiple analyses and estimated underlying mechanisms related to brain structure, immunometabolism and genetics.

The authors conducted a systematic review and individual participant data meta-analysis of 14 studies to evaluate psychological interventions for depression relapse prevention.

Using a large sample from the UK Biobank, the authors investigate the effects of dietary patterns on multiple aspects of brain health and mental health.

The authors conducted a systematic review and individual participant data meta-analysis of 14 studies to evaluate psychological interventions for depression relapse prevention.

In a large dataset from the UK Biobank, the authors examine the relationships between regional gene expressions and structural and functional features of the cerebral cortex associated with risky behavior.

Translational science is often characterized metaphorically, as bridging the gaps among multidisciplinary research areas. However, in reality, translational work is often separate or excluded from clinical research. Integrating elements of translational and clinical work into more general mental health research is key to innovation and progress.

In this Perspective, authors overview the ‘social cure’ model employing group contexts, identity, and connections and argue for its use as a therapeutic framework for psychedelic treatment.

This study examining blood transcriptomic, neuroimaging and clinical data in people with schizophrenia shows a relationship between individual variations in gene transcription, brain structure and cognitive performance.

In this Q&A, we speak to Andrew Zalesky, professor at the University of Melbourne, a co-leader of the Systems Lab and awardee of the prestigious Rebecca L. Cooper Fellowship that provides US$1.35 million over 5 years to study brain networks in health and disease and develop high-tech psychiatric therapies based on brain stimulation. He also led the development of the Melbourne Subcortex Atlas and is recognized for the novel tools he has developed to analyze brain networks.

In this study, the authors used molecular brain imaging and measures of neuroticism to identify that high 5-HT_2AR binding and higher levels of neuroticism predicted an increased risk of developing depression up to 19 years after assessment.

The opioid abuse epidemic is a major health concern that requires new pain management strategies. Findings now show that suvorexant, a dual hypocretin receptor antagonist, reverses the anatomical and circuit alterations induced by opioids and decreases addictive behavior while maintaining the analgesic properties of the drugs.

This study maps cerebellar anatomy across the lifespan using over 54,000 brain scans from 132 scanning sites and identifies that patients with autism spectrum disorder, mild cognitive impairment, Alzheimer disease, and schizophrenia are likely to have deviations in cerebellar anatomy.