Zhao, Yang et al. used UK Biobank data to examine the role of lifestyle factors in depression. They conducted multiple analyses and estimated underlying mechanisms related to brain structure, immunometabolism and genetics.

The authors conducted a systematic review and individual participant data meta-analysis of 14 studies to evaluate psychological interventions for depression relapse prevention.

Using a large sample from the UK Biobank, the authors investigate the effects of dietary patterns on multiple aspects of brain health and mental health.

The authors conducted a systematic review and individual participant data meta-analysis of 14 studies to evaluate psychological interventions for depression relapse prevention.

In this study, the authors use a transdiagnostic approach to assess functional connectivity in individuals with and without a psychiatric diagnosis, showing hypoconnectivity in the default mode, visual and limbic systems associated with suicidality.

In this Perspective, the authors review the literature regarding the differences between autobiographical and traumatic memory and introduce sensorimotor-based implications for understanding and treating post-traumatic stress disorder.

Integrative analyses that incorporate different levels of ‘-omics’ data represent a powerful tool for deciphering the biological mechanisms that underlie environmental influences on mental health and disease. This Comment highlights various aspects of such multi-omics approaches, using the example of the EU-funded environMENTAL project.

This Comment presents a high-level protocol for data harmonization within large cohorts, in which it postulates four main steps including (1) expert review, (2) pre-statistical harmonization, (3) statistical harmonization, and (4) validation.

The focus of much of contemporary research ethics is on compliance with established protocols. However, large data-driven neuroscience research raises new ethical concerns that have no agreed-upon solution. Here we reflect on these challenges and propose better integration of public and patient involvement in this evolving landscape.

This Comment explores new approaches to enrich large-scale population data, including incorporating macro-environmental and digital health measures.

To improve the reliability of research on the therapeutic benefits of psychedelics beyond placebo and expectation effects, the authors discuss the methodological considerations for selecting suitable control conditions in psychedelic trials and the neurobiology of placebo and expectation effects.

Using a large multisite dataset of people with major depressive disorder and healthy controls, the authors show global brain connectivity alterations in the sensorimotor, visual, and default mode networks.

Using multimodal brain imaging and organ-specific physiological markers from more than 18,000 adult participants of the UK Biobank database, this study reveals integrated pathways that explain the interplay between brain, body, environment and lifestyle, and their collective influence on mental health outcomes.