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Volume 5 Issue 3, March 2021

Volume 5 Issue 3

Parasexual recombination in cancer cells

Within a colony that originates from a single hybrid cell and is formed by spontaneous fusion of differentially labelled breast cancer cells, most cells maintain the expression of both parent-specific fluorescent markers. However, a subset of cells lost the expression of the green marker, with some cells migrating away from the colony, suggesting subclonal diversification within the progeny of the hybrid clone.

See Miroshnychenko et al.

Image: Andriy Marusyk et al. Cover Design: Allen Beattie.

Editorial

Correspondence

Comment & Opinion

  • Comment |

    The United Nations Decade of Ocean Science for Sustainable Development presents an exceptional opportunity to effect positive change in ocean use. We outline what is required of the deep-sea research community to achieve these ambitious objectives.

    • Kerry L. Howell
    • Ana Hilário
    • Joana R. Xavier
  • Comment |

    At 50, the Convention on Wetlands (Ramsar, 1971) has a mixed legacy. To survive and stay relevant in the Anthropocene, the convention will need to embrace new ecological thinking and conservation approaches.

    • Peter Bridgewater
    • Rakhyun E. Kim

News & Views

  • News & Views |

    Natural selection does not disappear with age, according to a new evolutionary demographic model. This conclusion is at odds with the widespread belief that ending reproduction relaxes purifying selection on alleles that increase our ageing body’s vulnerability to diseases such as cancer, Alzheimer’s or diabetes.

    • Emmanuel Milot

Reviews

  • Review Article |

    This Review highlights how information from archaeology, history, palaeoecology and other past sources can, and should, be used to inform plans to enhance the sustainability and resilience of our societies.

    • Nicole Boivin
    • Alison Crowther
  • Perspective |

    Ecosystems that exhibit long periods of transient dynamics pose particular challenges for management because state shifts can occur in the absence of exogenous drivers. In this Perspective, the authors outline how different transient behaviours can be influenced by management actions, and how understanding their causal mechanisms can guide future mitigation strategies.

    • Tessa B. Francis
    • Karen C. Abbott
    • Mary Lou Zeeman

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