Close-up of a bonfire burning.

April issue now live!

Our April issue includes a Comment on taking inspiration from epidemic modeling to improve wildfire resilience, and a Resource for high-resolution simulations of large and complex biological tissues.


  • A depiction of the brain using neurons and computing hardware.

    In this cross-journal collection, we aim to bring together cutting-edge research on neuromorphic architectures and hardware, computing, and algorithms, as well as related applications. We also invite commentaries from experts in the field.

    Open for submissions
  • A physical, real city overlaid with a representation of a digital city, which includes three-dimensional depictions of buildings.

    There has been a growing interest and enthusiasm in using digital twins to accelerate scientific discovery and to help researchers and stakeholders with critical decision-making tasks. Check out our Focus that highlights the state of the art, challenges, and opportunities in the development and use of digital twins across different domains.

  • An image that echoes the SDG logo and integrates the idea of analysis of data from the various goals.

    The year 2023 marks the mid-point of the 15-year period envisaged to achieve the Sustainable Development Goals. In this Nature Portfolio Collection, you will find studies across different journals that assess progress or that showcase interventions that have made a difference. We also welcome submissions of studies framed in a similar way.

    Open for submissions

Nature Computational Science is a Transformative Journal; authors can publish using the traditional publishing route OR via immediate gold Open Access.

Our Open Access option complies with funder and institutional requirements.


  • The authors develop the tool RESHAPE to share reference panels in a safer way. The genome–phenome links in reference panels can generate re-identification threats and RESHAPE breaks these links by shuffling haplotypes while preserving imputation accuracy.

    • Théo Cavinato
    • Simone Rubinacci
    • Olivier Delaneau
    ArticleOpen Access
  • Cooperation is not merely a dyadic phenomenon, it also includes multi-way social interactions. A mathematical framework is developed to study how the structure of higher-order interactions influences cooperative behavior.

    • Anzhi Sheng
    • Qi Su
    • Joshua B. Plotkin
  • This study introduces SANGO, a method for accurate single-cell annotation leveraging genomic sequences around accessibility peaks within single-cell ATAC sequencing data. SANGO consistently outperforms existing methods across diverse datasets for identification of cell type and detection of unknown tumor cells. SANGO enables the discovery of cell-type-specific functional insights through expression enrichment, cis-regulatory chromatin interactions and motif enrichment analyses.

    • Yuansong Zeng
    • Mai Luo
    • Yuedong Yang
  • We highlight the vibrant discussions on quantum computing and quantum algorithms that took place at the 2024 American Physical Society March Meeting and invite submissions that notably drive the field of quantum information science forward.

  • Wildfires have increased in frequency and intensity due to climate change and have had severe impacts on the built environment worldwide. Moving forward, models should take inspiration from epidemic network modeling to predict damage to individual buildings and understand the impact of different mitigations on the community vulnerability in a network setting.

    • Hussam Mahmoud
  • Digital twins hold immense promise in accelerating scientific discovery, but the publicity currently outweighs the evidence base of success. We summarize key research opportunities in the computational sciences to enable digital twin technologies, as identified by a recent National Academies of Sciences, Engineering, and Medicine consensus study report.

    • Karen Willcox
    • Brittany Segundo
  • Digital twins of Earth have the capability to offer versatile access to detailed information on our changing world, helping societies to adapt to climate change and to manage the effects of local impacts, globally. Nevertheless, human interaction with digital twins requires advances in computational science, particularly where complex geophysical data is turned into information to support decision making.

    • Peter Bauer
    • Torsten Hoefler
    • Wilco Hazeleger