Repulsion versus attraction
It had been suggested for a long time that enzymes use charge repulsion to promote catalysis. The enzyme orotidine-5’-monophosphate decarboxylase served as a reference system for this proposal. Now, Diederichsen, Mata, Tittmann and colleagues present the structural analysis of this enzyme in complex with the genuine substrate, which unexpectedly reveals that the charged groups of substrate and enzyme do not repel each other but share a proton in a productive interaction.
See Rindfleisch et al.