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Volume 2 Issue 12, December 2019

Branching through ring contraction

The branched pentose sugar d-apiose forms borate ester-polysaccharide crosslinks essential for plant cell wall development. Here the authors elucidate the multi-step reaction mechanism of UDP-apiose/UDP-xylose synthase involving decarboxylation of the UDP-d-glucuronic acid precursor coupled to pyranosyl-to-furanosyl sugar ring contraction by using the enzyme crystal structures and computational simulations.

See Savino et al.

Image: Luminous Lab. Cover Design: Alex Wing.

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