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Synthetic chemical processes often do not operate at sustainable or mild conditions—in contrast with natural complex reaction networks. This Perspective provides a roadmap for bio-inspired integrated catalytic systems for chemical manufacturing, sketching a biologically based future of industrial catalysis.
Genetic incorporation of unnatural amino acids into proteins broadens the possibilities of enzyme design. This Perspective discusses the exciting opportunities for biocatalysis offered by this method — such as new-to-nature catalytic activities — and potential benefits over classical enzyme engineering.
