Image: Jun Li and Yi Cui (Stanford University). Cover design: Karen Moore.

Issue 8 Live.

Nature Catalysis covers all areas of catalysis, incorporating the work of scientists, engineers and industry. Issue 8 now live.

Latest Research

  • Perspective |

    The histidine brace found in certain copper oxidases enables the oxidation of strong C–H bonds in organic substrates. This Perspective highlights and discusses the possible structural and electronic features of this motif and how these features underlie its role in challenging oxidative catalysis.

    • Luisa Ciano
    • , Gideon J. Davies
    • , William B. Tolman
    •  & Paul H. Walton
  • Article |

    Multicomponent couplings allow the rapid formation of molecular complexity from simple starting materials. Now, Ellman and co-workers report a three-component coupling that proceeds via aryl or vinyl C–H addition to dienes and aldehydes, and elucidate the mechanism by isolating a catalyst-bound intermediate. The C–H addition does not occur without all three components in place.

    • Jeffrey A. Boerth
    • , Soham Maity
    • , Sarah K. Williams
    • , Brandon Q. Mercado
    •  & Jonathan A. Ellman
  • Article |

    Prenylation is a common step in the synthesis of many natural products, and enantioselective variants require the use of enzymatic catalysts. Now, You and co-workers report a palladium phosphoramidite catalyst capable of enantioselective, dearomative prenylations across a broad range of starting materials, and demonstrate its power in a number of natural product syntheses.

    • Hang-Fei Tu
    • , Xiao Zhang
    • , Chao Zheng
    • , Min Zhu
    •  & Shu-Li You
  • Article |

    High activity and stability of enzyme cascades are key to their biotechnological application. Here, Willner and co-workers demonstrate that encapsulation in metal–organic framework nanoparticles can improve these features for two- and three-enzyme, as well as NAD+-dependent, cascades.

    • Wei-Hai Chen
    • , Margarita Vázquez-González
    • , Amani Zoabi
    • , Raed Abu-Reziq
    •  & Itamar Willner
  • Article |

    The synthesis of nanocatalysts with small dimensions and high surface-to-volume ratios is of great interest to lower catalyst costs and exploit catalytic performance enhancements through size effects. Now, Prinz and colleagues show that two-dimensional growth of platinum nanoparticles with suppressed thicknesses can be promoted with passivation-gas-incorporated atomic layer deposition.

    • Shicheng Xu
    • , Yongmin Kim
    • , Joonsuk Park
    • , Drew Higgins
    • , Shih-Jia Shen
    • , Peter Schindler
    • , Dickson Thian
    • , J. Provine
    • , Jan Torgersen
    • , Tanja Graf
    • , Thomas D. Schladt
    • , Marat Orazov
    • , Bernard Haochih Liu
    • , Thomas F. Jaramillo
    •  & Fritz B. Prinz
  • Article |

    The bioenergetic metabolism of all life today depends on proton gradients; however, it remains unclear how such gradients developed in early life. Here, Mansy and co-workers establish a possible prebiotic mechanism in which iron–sulfur peptide redox networks generate a trans-membrane pH gradient.

    • Claudia Bonfio
    • , Elisa Godino
    • , Maddalena Corsini
    • , Fabrizia Fabrizi de Biani
    • , Graziano Guella
    •  & Sheref S. Mansy

News & Comment

  • Editorial |

    Catalysis research has immensely benefited from the use of high-performance computing facilities. On the occasion of the twenty-fifth anniversary of the first Top500 list, we briefly revisit its content and evolution and the impact that supercomputers have had in catalysis.

  • News & Views |

    The chemical synthesis of natural products, such as sesquiterpenes, is a daunting task due to their complexity and precise functionalization, and multiple synthetic and purification steps that reduce overall yields are usually required. Now, a highly efficient alternative approach using supramolecular chemistry has been proposed by Tiefenbacher and co-workers.

    • Dan Thomas Major
  • News & Views |

    Metalloprotein activity can be tuned by altering first- and second-sphere interactions with the metal ion or ions. Here, a non-canonical haem axial ligand is introduced into a myoglobin variant, modulating both. The resulting enhancement of cyclopropanation activity illustrates the utility of expanding the suite of available amino acids for biocatalyst engineering.

    • Emily H. Edwards
    •  & Kara L. Bren
  • News & Views |

    How the first metabolic network was organized to power a cell remains an enigma. Now, simple iron–sulfur peptides have been used to generate a pH-gradient across a protocell membrane by catalysing hydrogen peroxide reduction. This indicates that short peptides could have fulfilled the role of redox active metalloproteins in early life.

    • Saidul Islam
    •  & Matthew W. Powner

About the Journal

  • Nature Catalysis brings together researchers from across all chemistry and related fields. It publishes work on homogeneous catalysis, heterogeneous catalysis and biocatalysts, incorporating both fundamental and applied studies. Nature Catalysis provides coverage of the science and business of catalysis research, creating a unique journal for scientists, engineers and researchers in industry.
  • Nature Catalysis publishes original research as Articles. We also publish a range of other content types including Reviews, Perspectives, Comments, Correspondences, News & Views and Feature articles.
  • The Chief Editor of Nature Catalysis is Enda Bergin, who was previously Senior Editor and Team Manager at Nature Communications; other editors are Davide Esposito, Marçal Capdevila-Cortada and Jan-Stefan Völler.
  • Contact information for editorial staff, submissions, the press office, institutional access and advertising at Nature Catalysis