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Volume 3 Issue 5, May 2024

Macrophages improve the function of engineered cardiac microtissue

Hamidzada et al. show that after integration of human embryonic stem cell-derived macrophages into human cardiac microtissue, they adopt the resident fate and improve microtissue function by ingesting stressed cardiomyocytes or their cargo by efferocytosis.

See Hamidzada et al.

Image: Ella Maru Studio. Cover design: Bethany Vukomanovic

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  • The mechanisms by which stroke and myocardial infarction trigger lymphocyte loss remain poorly defined. This study shows that the release of neutrophil extracellular traps (NETs) after stroke and myocardial infarction triggers B cell apoptosis and reduces the number of IgA-producing plasma cells. Therapeutic targeting of NETs is immunoprotective in mice and humans.

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  • By dissecting the cell composition and function of arterial grafts derived from the internal thoracic, radial and right gastroepiploic arteries, we identified factors that might promote patency rates of arterial grafts, including combating lipid deposition, disturbances in wall shear stress, smooth muscle cell proliferation, fibrosis and spasm.

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